Results 81 to 90 of about 1,164,284 (355)

Computational simulations demonstrate altered wall shear stress in aortic coarctation patients previously treated by resection with end-to-end anastomosis [PDF]

, 2011
Background.  Atherosclerotic plaque in the descending thoracic aorta (dAo) is related to altered wall shear stress (WSS) for normal patients. Resection with end-to-end anastomosis (RWEA) is the gold standard for coarctation of the aorta (CoA) repair, but
Cava, Joseph Richard, Chan, Frandics P, Dholakia, Ronak Jashwant, Feinstein, Jeffrey A., Figueroa, Alberto, LaDisa, John F., Samyn, Margaret M, Taylor, Charles A., Vignon-Clementel, Irene E   +8 more
core   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Anatomic brain asymmetry in vervet monkeys. [PDF]

, 2011
Asymmetry is a prominent feature of human brains with important functional consequences. Many asymmetric traits show population bias, but little is known about the genetic and environmental sources contributing to inter-individual variance.
Abaryan, Zvart, Cantor, Rita M, Fairbanks, Lynn A, Fears, Scott C, Freimer, Nelson B, Jorgensen, Matthew J, Lee, Chris, Scheibel, Kevin, Service, Susan K, Woods, Roger P   +9 more
core   +1 more source

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

Molecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren, Philippe Decruyenaere, Francisco Avila Cobos, Johanna Bult, Jill Deleu, Laudonia Lidia Dipalo, Hetty Hilde Helsmoortel, Eva Hulstaert, Annelien Morlion, Elena Ramos Varas, Kathleen Schoofs, Wim Trypsteen, Eveline Vanden Eynde, Hanne Van Droogenbroeck, Kimberly Verniers, Jo Vandesompele, Anneleen Decock   +16 more
wiley   +1 more source

Elastomers three-dimensional biomodels proven to be a trustworthy representation of the angiotomographic images

Arquivos de Neuro-Psiquiatria
Intracranial aneurysm (IA) rupture is responsible for 80% of spontaneous arachnoid hemorrhages and associated with an extremely high mortality rate. Two possible surgical interventions are endovascular embolization and microsurgical clipping.
André Giacomelli Leal, Leonardo Brancia Pagnan, Raphael Teruaki Kondo, José Aguiomar Foggiatto, Guilherme José Agnoletto, Ricardo Ramina   +5 more
doaj   +1 more source

Emerging technologies to create inducible and genetically defined porcine cancer models

Frontiers in Genetics, 2016
There is an emerging need for new animal models that address unmet translational cancer research requirements. Transgenic porcine models provide an exceptional opportunity due to their genetic, anatomic and physiological similarities with humans.
Lawrence B Schook, Lawrence B Schook, Laurie A. Rund, Karine eBegnini, Mariana Härter Remião, Fabiana Kommling Seixas, Tiago V. Collares   +6 more
doaj   +1 more source

Towards anatomic scale agent-based modeling with a massively parallel spatially explicit general-purpose model of enteric tissue (SEGMEnT_HPC). [PDF]

PLoS ONE, 2015
Perhaps the greatest challenge currently facing the biomedical research community is the ability to integrate highly detailed cellular and molecular mechanisms to represent clinical disease states as a pathway to engineer effective therapeutics.
Robert Chase Cockrell, Scott Christley, Eugene Chang, Gary An   +3 more
doaj   +1 more source

Including Aortic Valve Morphology in Computational Fluid Dynamics Simulations: Initial Findings and Application to Aortic Coarctation [PDF]

, 2012
Computational fluid dynamics (CFD) simulations quantifying thoracic aortic flow patterns have not included disturbances from the aortic valve (AoV). 80% of patients with aortic coarctation (CoA) have a bicuspid aortic valve (BAV) which may cause adverse ...
Cava, Joseph Richard, Ellwein, Laura M, Gandy, Kimberly L., Krolikowski, Mary M., LaDisa, John F., Pelech, Andrew N., Samyn, Margaret M., Shadden, Shawn C., Wendell, David C.   +8 more
core   +2 more sources

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Feature-Based Design of Personalized Anatomical Plates for the Treatment of Femoral Fractures

IEEE Access, 2021
In this study, we propose a feature-based method of anatomic plate design for the treatment of individual femoral fractures. This approach improves the design efficiency and convenience of personalized plates.
Xiaozhong Chen, Zhijian Mao, Xi Jiang
doaj   +1 more source