Results 21 to 30 of about 93,580 (259)

Improving a probabilistic cytoarchitectonic atlas of auditory cortex using a novel method for inter-individual alignment

eLife, 2020
The human superior temporal plane, the site of the auditory cortex, displays high inter-individual macro-anatomical variation. This questions the validity of curvature-based alignment (CBA) methods for in vivo imaging data.
Omer Faruk Gulban, Rainer Goebel, Michelle Moerel, Daniel Zachlod, Hartmut Mohlberg, Katrin Amunts, Federico de Martino   +6 more
doaj   +1 more source

Functional Alignment Philosophy in Total Knee Arthroplasty – Rationale and technique for the varus morphotype using a CT based robotic platform and individualized planning

SICOT-J, 2022
Introduction: Alignment techniques in total knee arthroplasty (TKA) continue to evolve. Functional alignment (FA) is a novel technique that utilizes robotic tools to deliver TKA with the aim of respecting individual anatomical variations.
Shatrov Jobe, Battelier Cécile, Sappey-Marinier Elliot, Gunst Stanislas, Servien Elvire, Lustig Sebastien   +5 more
doaj   +1 more source

Anatomical axes of the proximal and distal halves of the femur in a normally aligned healthy population: implications for surgery

Journal of Orthopaedic Surgery and Research, 2018
Background The anatomical axis of the femur is crucial for determining the correct alignment in corrective osteotomies of the knee, total knee arthroplasty (TKA), and retrograde and antegrade femoral intramedullary nailing (IMN).
Hamidreza Yazdi, Ara Nazarian, John Y. Kwon, Mary G. Hochman, Reza Pakdaman, Poopak Hafezi, Morteza Ghahremani, Samad Joudi, Mohammad Ghorbanhoseini   +8 more
doaj   +1 more source

Association of frontal plane knee alignment with foot posture in patients with medial knee osteoarthritis

BMC Musculoskeletal Disorders, 2017
Background To examine the association of radiographic frontal plane knee alignment with three-dimensional foot posture in patients with medial knee osteoarthritis (OA).
Hiroshi Ohi, Hirotaka Iijima, Tomoki Aoyama, Eishi Kaneda, Kazuko Ohi, Kaoru Abe   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Distribution of phenotypes of coronal plane alignment of the knees and functional phenotypes in the healthy young Iranian population: A cross‐sectional study

Journal of Experimental Orthopaedics
Purpose The functional phenotypes and the coronal plane alignment knee (CPAK) classification have recently been introduced. This study aimed to describe the phenotypes of normal knees in the healthy young Iranian population based on these systems ...
Mohammadreza Razzaghof, Mohammad Soleimani, Mohammad Poursalehian, Mohammad Ayati Firoozabadi, Seyed Amirsadegh Mortazavi, Seyed Mohammad Javad Mortazavi   +5 more
doaj   +1 more source

A comparison of five approaches to measurement of anatomic knee alignment from radiographs [PDF]

Osteoarthritis and Cartilage, 2010
The recent recognition of the correlation of the hip-knee-ankle angle (HKA) with femur-tibia angle (FTA) on a standard knee radiograph has led to the increasing inclusion of FTA assessments in OA studies due to its clinical relevance, cost effectiveness and minimal radiation exposure.
McDaniel, G., Mitchell, K.L., Charles, C., Kraus, V.B.   +3 more
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Surgical Outcome Prediction Using a Four-Dimensional Planning Simulation System With Finite Element Analysis Incorporating Pre-bent Rods in Adolescent Idiopathic Scoliosis: Simulation for Spatiotemporal Anatomical Correction Technique

Frontiers in Bioengineering and Biotechnology, 2021
An optimal surgical strategy for adolescent idiopathic scoliosis (AIS) is to provide maximal deformity correction while preserving spinal mobile segments as much as possible and obtaining a balanced posture.
Hiroyuki Tachi, Hiroyuki Tachi, Koji Kato, Yuichiro Abe, Terufumi Kokabu, Katsuhisa Yamada, Norimasa Iwasaki, Hideki Sudo, Hideki Sudo   +8 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source