Results 41 to 50 of about 345 (196)

A State‐Gated Metallo‐DNAzyme Framework Programs Tumor Stress Vulnerability Through Metabolic Licensing

Advanced Science, EarlyView.
A tumor‐state‐gated metallo‐DNAzyme framework integrates miR‐21/APE1‐responsive GLUT1 silencing with Ca/Cu‐partitioned metal–nucleic acid assembly and cystine loading. The framework first weakens glucose‐dependent metabolic buffering and then amplifies copper‐ and disulfide‐associated stress, converting tumor metabolic adaptation into programmable ...
Xiaodong Ma, Lingyun He, Xinru Wang, Yuanyuan Wei, Chengcheng Li, Jiaqi Yan, Weijian Sun, Xian Shen, Hongbo Zhang   +8 more
wiley   +1 more source

Comprehensive mapping of the exterior architecture of the dromedary camel brain

Scientific Reports
The morphological perspective of the camel brain remains largely unexplored. Therefore, studying the topography of the camel brain is of crucial importance.
Ahmad Al Aiyan, Rinsha Balan, Senit Gebreigziabiher, Simona Zerom, Yotam Mihreteab, Even Ghebrehiwot, Adnan AlDarwich, Arve Lee Willingham, Uday Kishore   +8 more
doaj   +1 more source

Towards a Compositional Framework for Describing Human Phenotypes

Advanced Science, EarlyView.
The Phenotype Assembly Method (PhenoAM) decomposes phenotype variables into measurable Features and typed Qualifiers, enabling standardized, machine‐readable Phenome Data Elements (PhenoDEs) that preserve measurement context. Applied in the International Human Phenome Project (IHPP), the framework yields 58 371 PhenoDEs and supports component‐level ...
Wanting Hu, Yunchao Ling, Xinyue Hu, Wei Chen, Rong Zhou, Xinhao Zhuang, Yanfeng Jiang, Jialu Zhao, Xingdong Chen, Jingchun Luo, Li Jin, Guoqing Zhang   +11 more
wiley   +1 more source

The Foot Musculature of the Rhesus Monkey (Macaca mulatta): An Anatomical Study

Anatomia
The rhesus monkey (Macaca mulatta) is a non-human primate with a genome that is 93.5% identical to that of humans. Both species, therefore, have numerous phenotypical similarities in common.
Christophe Casteleyn, Max Bosmans, Sofie Muylle, Jaco Bakker   +3 more
doaj   +1 more source

Wood Carbon Sponge/SiO2 Aerogel Composites with Anisotropic Broadband Microwave Absorption, Elastic Resilience, and Thermal Insulation

Advanced Science, EarlyView.
Anisotropic wood carbon sponge/SiO2 aerogel composites are constructed, revealing a robust direction‐dependent permittivity ordering (tangential > radial > axial). The radial direction delivers an ultra‐broadband effective absorption bandwidth of 11.6 GHz at only 4.95 mm, while the tangential direction offers superior compressibility and thermal ...
Shuo Sun, Zhimeng Zhao, Weikai Zhan, Yonggang Jiang, Fengqi Liu, Yijie Hu, Junzong Feng, Jian Feng   +7 more
wiley   +1 more source

Preoperative FIB‐4 Index as a Potential Factor Associated With Severe Postoperative Complications and Endogenous Organ Failure After Hepatectomy for Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
This study demonstrates that a preoperative FIB‐4 index ≥ 5.0 independently predicts severe complications and endogenous organ failure (EOF) following hepatectomy for hepatocellular carcinoma. By capturing structural liver fragility and systemic vulnerability, the FIB‐4 index enhances surgical risk stratification beyond traditional functional markers ...
Masanori Nakamura, Yukiyasu Okamura, Osamu Aramaki, Nao Yoshida, Yusuke Mitsuka, Hayato Abe, Shunsuke Yamagishi, Yasuhiro Okumura, Kyongsun Pak, Shinobu Masuda   +9 more
wiley   +1 more source

Orbitofrontal sulcal and gyrus pattern in human: an anatomical study

Arquivos de Neuro-Psiquiatria, 2015
The anatomical characterization of the orbitofrontal cortex in human is limited in literature instead of many functional and clinical studies involving it. Objective Anatomically define the orbitofrontal region aiming to possible neurosurgical treatments
Thiago Pereira Rodrigues, Mariana Athaniel Silva Rodrigues, Daniel de Araújo Paz, Marcos Devanir Silva da Costa, Ricardo Silva Centeno, Feres Eduardo Chaddad Neto, Sergio Cavalheiro   +6 more
doaj   +1 more source

Laparoscopic Versus Open Surgery for Diverticular Disease: A Structured Review Across Clinical Settings and Operative Strategies

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Laparoscopic surgery is increasingly used to treat colonic diverticulitis; however, its role in emergency, perforated, high‐risk, and procedure‐specific settings remains uncertain. This structured narrative review evaluated and synthesized comparative evidence by clinical setting, operative strategy, and patient risk profile to provide a ...
Marie Hanaoka, Yudai Fukui, Koya Hida, Hiroya Takeuchi, Yusuke Kinugasa   +4 more
wiley   +1 more source

Automating AI Discovery for Biomedicine Through Knowledge Graphs and Large Language Models Agents

Advanced Intelligent Discovery, EarlyView.
This work proposes a novel framework that automates biomedical discovery by integrating knowledge graphs with multiagent large language models. A biologically aligned graph exploration strategy identifies hidden pathways between biomedical entities, and specialized agents use this pathway to iteratively design AI predictors and wet‐lab validation ...
Naafey Aamer, Muhammad Nabeel Asim, Shan Munir, Andreas Dengel   +3 more
wiley   +1 more source

Unifying nomenclature describing the individuals with Fontan circulation

Annals of Pediatric Cardiology
Language shapes clinical care, research interpretation, and patient identity, particularly in chronic and heterogeneous conditions. Individuals living with a Fontan circulation represent a growing and diverse population unified by a surgically created ...
Ashish H. Shah, David Renaud, Sivasubramanian Ramakrishnan, Miriam Michel   +3 more
doaj   +1 more source