Results 61 to 70 of about 605,338 (243)

Self‐Healing Hydrogel‐Enabled Modular Assembly of Bilayered Skin Construct for Hair Follicle Regeneration

Advanced Healthcare Materials, EarlyView.
Self‐healing assembly of two cell‐laden hydrogel layers creates a biomimetic skin construct that restores both dermal and epidermal functions, resulting in accelerated wound healing and enhanced hair follicle regeneration in a full‐thickness skin wound model. ABSTRACT Alopecia remains a pervasive clinical challenge, largely owing to the limited ability
JaeWook Park, Su Yong Kim, MinSu Jeong, Beom Joon Kim, Shin Hyuk Kang, Won‐Gun Koh   +5 more
wiley   +1 more source

Cortical GABAergic Interneurons in Cross-Modal Plasticity following Early Blindness

Neural Plasticity, 2012
Early loss of a given sensory input in mammals causes anatomical and functional modifications in the brain via a process called cross-modal plasticity. In the past four decades, several animal models have illuminated our understanding of the biological ...
Sébastien Desgent, Maurice Ptito
doaj   +1 more source

Advances in 3D Bioprinting for Breast Cancer Modeling: Tumor Microenvironment, Metastasis, and Drug Screening

Advanced Healthcare Materials, EarlyView.
Three‐dimensional bioprinting transforms breast cancer modeling from simple constructs into spatially organized, multicellular, perfused, and patient‐derived platforms. This review shows how bioinks, cellular composition, architecture, and flow govern tumor behavior and drug response, while revealing why complexity alone is insufficient without ...
Mustafa Nakipoglu, Mahboobeh Mahmoodi, Ehsanul Hoque Apu, Fahimeh Shahabipour, Sibel Emir Diltemiz, Sanjib Saha, Halima Alem, Nureddin Ashammakhi   +7 more
wiley   +1 more source

MALADAPTIVE PLASTICITY IN LEVODOPA-INDUCED DYSKINESIAS AND TARDIVE DYSKINESIAS: OLD AND NEW INSIGHTS ON THE EFFECTS OF DOPAMINE RECEPTOR PHARMACOLOGY

Frontiers in Neurology, 2014
Maladaptive plasticity can be defined as behavioral loss or even development of disease symptoms resulting from aberrant plasticity changes in the human brain.
Antonio eCerasa, Alfonso eFasano, Francesca eMorgante, Giacomo eKoch, Aldo eQuattrone   +4 more
doaj   +1 more source

Human iPSC‐Derived Tissue‐Engineered Nigrostriatal Pathway for Chronic Restoration of Dopaminergic Axon Tracts in a Rat Parkinson's Model

Advanced Healthcare Materials, EarlyView.
Inspired by conventional cell therapy and emerging bioengineering approaches, the tissue‐engineered nigrostriatal pathway (TE‐NSP) has an anatomically‐inspired design comprising a population of human dopaminergic neurons with unidirectional, long‐projecting axon tracts.
Wisberty J. Gordián‐Vélez, Dimple Chouhan, Kevin D. Browne, James Lim, Saarang P. Karandikar, Rodrigo A. España, John E. Duda, H. Isaac Chen, D. Kacy Cullen   +8 more
wiley   +1 more source

Cortical overexpression of neuronal calcium sensor-1 induces functional plasticity in spinal cord following unilateral pyramidal tract injury in rat.

PLoS Biology, 2010
Following trauma of the adult brain or spinal cord the injured axons of central neurons fail to regenerate or if intact display only limited anatomical plasticity through sprouting.
Ping K Yip, Liang-Fong Wong, Thomas A Sears, Rafael J Yáñez-Muñoz, Stephen B McMahon   +4 more
doaj   +1 more source

GDNF‐Enriched Small Extracellular Vesicle‐Loaded ROS‐Scavenging Hydrogel Promotes Neural Regeneration After Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
A glial cell line‐derived neurotrophic factor (GDNF)‐enriched small extracellular vesicle‐loaded reactive oxygen species (ROS)‐scavenging hydrogel integrates sustained neurotrophic delivery with local modulation of oxidative and inflammatory stress after spinal cord injury. The composite hydrogel improves local vesicle retention, protects neural tissue,
Xingyu Zhu, Zhong Liu, Kewei Li, Yuhong Fan, Kangjia Yang, Xiaopeng Sun, Hang Shi, Lixuan Sun, Yang Lou, Min Wang, Peipei Wu, Hui Qian, Qiang Fu, Hua Ding   +13 more
wiley   +1 more source

Habitat-driven variability in morphological and anatomical traits of Dactyloctenium aegyptium (Poaceae) in semi-arid regions

BMC Plant Biology
Background The ability of Dactyloctenium aegyptium (L.) Willd. to adapt to diverse habitats reflects its remarkable ecological plasticity. Methods This study investigates the morphological and anatomical traits of D. aegyptium across six distinct habitat
Naila Mukhtar, Muhammad Waheed, Fahim Arshad, Nidaa Harun, Uzma Amin, Shaheena Umbreen, Abeer Al-Andal, Valisher Sapayev, Malokhat Saidmuratova, Abdul Rahman Osmani, Marina Taheri   +10 more
doaj   +1 more source

Leaftronics: Bio‐Fractal Scaffolds From Leaf Venation for Low‐Waste Electronics

Advanced Materials, EarlyView.
“Leaftronics” transforms naturally evolved leaf venation into quasi‐fractal scaffolds for sustainable electronics. Polymer‐infiltrated leaf skeletons can be used to fabricate ultra‐smooth, reflow‐ and thin‐film‐compatible decomposable substrates, while making the same lignocellulose networks conducting results in flexible transparent electrodes.
Rakesh Rajendran Nair, Hrisheekesh Thachoth Chandran, Karl Leo, Hans Kleemann   +3 more
wiley   +1 more source

Wearable Morphology‐Adaptive in‐Ear Device With Active Cleansing Capability for Multimodal Health Monitoring

Advanced Materials, EarlyView.
We present SCIENCE, an in‐ear multimodal physiological monitor featuring two key innovations. Water‐triggered morphological expansion (a 2‐mm cylinder to a 9‐mm spindle) achieves conformal adaptation across complex canal geometries. Simultaneously, active biofouling mitigation disrupts cerumen barriers, reducing sensor‐skin impedance by 20%.
Shuyun Zhuo, Zihuan Wu, Anan Zhang, Shideh Kabiri Ameri   +3 more
wiley   +1 more source