Results 211 to 220 of about 1,826,835 (356)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The Trifurcated Anatomy of The Upper Trunk of The Brachial Plexus: Suprascapular Nerve, Posterior Division, and Anterior Division. [PDF]

Rev Bras Ortop (Sao Paulo)
Neto JHS, Neto BC, Eiras ABD, Botelho RHS, Daflon LG, Passos MARDF.   +5 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Endoscopic Ultrasound-Guided Gastric Remnant Access for Massive Upper Gastrointestinal Bleeding in Roux-en-Y Anatomy. [PDF]

ACG Case Rep J
Pak SJ, Basso JE, Edelson JC.
europepmc   +1 more source

Effect of Inbreeding on Body Size, Anatomy, and Producing Capacity of Grade Holstein Cows

, 1949
W. W. Swett, C.A. Matthews, M. H. Fohrman, Swett, W. W., Matthews, C.A., Fohrman, M. H.   +5 more
openalex   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Biliary drainage in patients with altered anatomy: Literature review of different endoscopic approaches. [PDF]

World J Gastroenterol
Cocca S, Casoni Pattacini G, Grova A, Esposito S, Lupo M, Ferrante M, Grande G, Guidotti C, Pigò F, Li Cavoli TV, Mussetto A, Piccoli M, Conigliaro R, Bertani H.   +13 more
europepmc   +1 more source

Anatomy of the woodchuck (Marmota monax) / [PDF]

, 2005
Bezuidenhout, A. J. (Abraham Johannes), 1942-, Evans, Howard E. (Howard Edward), 1922-   +1 more
core   +2 more sources

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Clinical prediction of aortic arch anatomy to guide stroke CT angiography protocols: A machine learning study. [PDF]

Neuroradiol J
Marquez-Romero JM, Doubova SV, Bonifacio-Delgadillo DM, Muñoz-Zavala AE, Salinas-Gutiérrez R.   +4 more
europepmc   +1 more source