Results 71 to 80 of about 2,096,156 (396)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac+3 more
wiley +1 more source
Diagnosis of dental problems in pet rabbits (Oryctolagus cuniculus) [PDF]
Dental problems are very common in pet rabbits. To establish a correct diagnosis of rabbit dental pathology, a general knowledge of normal dental anatomy and physiology is necessary.
De Rycke, Lieve+5 more
core +1 more source
The nature of M-theory on K3 X I, where I is a line interval, is considered, with a view towards formulating a `matrix theory' representation of that situation.
Aldazabal+61 more
core +2 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Introduction Knowledge on the normal morphology of the human mandible and its possible anatomical variations are of fundamental importance in dental practice, especially in the areas of surgery and implantodontics.
George Borja de FREITAS+2 more
doaj +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Anatomy of Threats to the Internet of Things
The world is resorting to the Internet of Things (IoT) for ease of control and monitoring of smart devices. The ubiquitous use of IoT ranges from industrial control systems (ICS) to e-Health, e-Commerce, smart cities, supply chain management, smart cars,
Imran Makhdoom+4 more
semanticscholar +1 more source
Arterial variations of the femoral triangle are rarely reported in the literature. In the present article, we have reported a case of high origin of the deep femoral artery, which was originating just lower to the inguinal ligament.
Vishal Kumar+3 more
doaj +1 more source
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source