Results 241 to 250 of about 11,200,369 (343)

Roles of ER Membrane Protein Complex in Protein Biogenesis and Quality Control in the Lung and Beyond

open access: yesCell Proliferation, EarlyView.
The endoplasmic reticulum membrane protein complex (EMC) is an evolutionarily conserved, multi‐subunit transmembrane protein complex crucial to membrane protein biogenesis and cellular protein quality control. This review systematically examines the structure, functions and disease‐associated regulatory mechanisms of EMC across multiple organ systems ...
Yan Qiao   +6 more
wiley   +1 more source

Cross‐border reciprocal bartering in public–private tetradic networks

open access: yesDecision Sciences, EarlyView.
Abstract Under the background of semiconductor and vaccine shortages during COVID‐19‐driven supply chain disruptions, this article adopts a multimethodological approach to investigate strategic solutions for cross‐border scarce goods bartering in a public–private (P–P) tetradic reciprocal network, which involves two pairs of P–P collaborative dyads ...
Jiuh‐Biing Sheu   +2 more
wiley   +1 more source

Reframing Justice in Healthcare AI: An Ubuntu‐Based Approach for Africa

open access: yesDeveloping World Bioethics, EarlyView.
ABSTRACT There is an ongoing debate on how to balance the benefits and risks of artificial intelligence (AI), especially in healthcare. In resource‐constrained settings, such as Africa, where access to quality care remains a challenge, AI has the potential to improve efficiency, accessibility, and patient outcomes.
Aloysius Ochasi   +3 more
wiley   +1 more source

Sick leave in the United Kingdom Post Office, 1850–1908

open access: yesThe Economic History Review, EarlyView.
Abstract This paper uses a large individual‐record‐level dataset on sick leave to examine adult morbidity in the United Kingdom between 1850 and 1908. From 1859 onwards postal workers were eligible to receive a pension or gratuity when they retired or were forced to stop working due to ill health.
Harry Smith   +8 more
wiley   +1 more source

Dimerization‐dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH signalling inhibitors

open access: yesThe FEBS Journal, EarlyView.
NOTCH signalling is indispensable for tissue homeostasis and, consequently, corruption of its normal function promotes numerous diseases, including cancer. However, the development of targeted therapies has been hampered by inefficacy and overt toxicity. Here, we show that NOTCH receptor dimerization is necessary for receptor transactivation, which has
Xinxin Liu   +9 more
wiley   +1 more source

Home - About - Disclaimer - Privacy