RETRACTED: Toncheva et al. Pathogenic Variants Associated with Rare Monogenic Diseases Established in Ancient Neanderthal and Denisovan Genome-Wide Data. <i>Genes</i> 2023, <i>14</i>, 727. [PDF]
Genes (Basel)Toncheva D +3 more
europepmc +1 more source
Proteostasis of organelles in aging and disease
The FEBS Journal, EarlyView.Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
wiley +1 more source
Parasitology at the heart of the "One Health" concept: a longstanding alliance illustrated by cysticercosis control. [PDF]
ParasiteDupouy-Camet J +4 more
europepmc +1 more source
The FEBS Journal, EarlyView.Polyphosphate interaction with Hfq and RNA drives phase separation and amyloid self‐assembly, uncovering a previously unrecognized role for polyP in bacterial stress responses. Our findings reveal new insights into the molecular mechanisms of RNA‐mediated phase separation, highlighting the role of polyP as a key modulator of this process. Polyphosphate
Kevin Mosca +5 more
wiley +1 more source
Pathogenic variation in human DNA damage repair genes was originated from the evolutionary process of modern humans. [PDF]
Genes DisLi J +11 more
europepmc +1 more source
GCN2 in proteostasis: structural logic, signalling networks and disease
The FEBS Journal, EarlyView.Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley +1 more source
A tuberkulózis megjelenése a Dunántúl kései neolitikumában. - The Emergence of Tuberculosis in Late Neolithic Transdanubia [PDF]
, 2013 Köhler, Kitti +2 more
core
The FEBS Journal, EarlyView.Okur‐Chung neurodevelopmental syndrome (OCNDS) is a neurodevelopmental disorder associated with mutations in the gene coding for Protein kinase CK2α. In this work, 42 variants of CK2α associated with OCNDS were characterized in vitro. This included determination of catalytic activity and CK2α/CK2β‐interaction as well as an assessment of evolutionary ...
Alexander Gast +3 more
wiley +1 more source
The use of minerals, plants and burnt materials in ancient medicine: Approaches to working recipes in John the Physician's <i>Therapeutics</i> from late 13th century Cyprus. [PDF]
Proc Geol AssocScott AC +9 more
europepmc +1 more source
Water, water, every where—the advent of hydrated pili structure
The FEBS Journal, EarlyView.Protein structure is defined by its surrounding water. Naturally, this is also true for the gigantic protein filaments that pathogenic bacteria use to attach to and colonize their host cells. Structures of these filaments for which water can be identified with high confidence have stayed elusive for the longest time.
Hiroya Oki +3 more
wiley +1 more source