Results 171 to 180 of about 3,058,276 (339)

Phytochemical‐Based Strategies for Lung Cancer: Clinical Insights Into Pleiotropic Molecular Signaling and Therapeutic Roles

Phytotherapy Research, EarlyView.
Lung cancer (LC) remains the leading cause of global cancer‐related death. Phytochemicals from medicinal plants are increasingly being considered as potential LC treatment agents due to their multi‐targeted action, safety, and accessibility. These have anticancer properties by regulating key molecular signaling pathways.
Md. Rezaul Islam, Abdur Rauf, Happy Akter, Md. Ibrahim Khalil Al‐Imran, Md. Naeem Hossain Fakir, Gazi Kaifeara Thufa, Umme Habiba, Karjin Nahar Riya, Md. Mahfuzur Rahman, Md Sadique Hussain, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Dorota Formanowicz, Marcello Iriti   +14 more
wiley   +1 more source

Pedunculoside Inhibits Hepatocellular Carcinoma Progression by Activating the MAPK Signaling Pathway Through Targeting and Suppressing CDK4

Phytotherapy Research, EarlyView.
Pedunculoside targets and suppresses CDK4; consequently, it activates the MAPK pathway and inhibits hepatocellular carcinoma progression. ABSTRACT Hepatocellular carcinoma (HCC) remains a major challenge in cancer prevention and treatment, highlighting the urgent need for effective and low‐toxicity anti‐HCC therapies. Recently, CDK4‐targeted inhibitors
Yang Zhou, Jingyun Chi, Yuan Ding, Zhidi Zhang, Rui Liang, Tianhao Wang, Yan Jiang, Rujun Song, Huazhou Fu, Xizhen Zhou   +9 more
wiley   +1 more source

Genetic transitions in the Neolithic and Bronze Age at Mas d’en Boixos (Catalonia, Spain)

iScience
Summary: Mas d’en Boixos is a key prehistoric site in Northeastern Iberia spanning from the Early Neolithic to the Late Iron Age. We analyzed genome-wide data from eight individuals and ten mitogenomes, dated to the Middle Neolithic and Early Bronze Age,
Xavier Roca-Rada, Daniel R. Cuesta-Aguirre, Diana C. Vinueza-Espinosa, Roberta Davidson, Shyamsundar Ravishankar, Leonard Taufik, Núria Armentano, Xavier Esteve, Yassine Souilmi, João C. Teixeira, Assumpció Malgosa, Bastien Llamas, Cristina Santos   +12 more
doaj   +1 more source

Using MALDI‐FTICR Mass Spectrometry to Enhance ZooMS Identifications of Pleistocene Bone Fragments Showing Variable Collagen Preservation

Rapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale Recent advances in high‐throughput molecular analyses of collagen peptides, especially ZooMS (Zooarchaeology by Mass Spectrometry), have permitted breakthroughs in the analysis of archaeological material that is highly fragmented, a factor that hinders morphological identification.
Pauline Raymond, Karen Ruebens, Fabrice Bray, Jean‐Christophe Castel, Eugène Morin, Foni Le Brun‐Ricalens, Jean‐Guillaume Bordes, Christian Rolando, Jean‐Jacques Hublin   +8 more
wiley   +1 more source

Untreated Hair Dye Effluents Enter the Environment: Are They a Threat to Human Health?

Environmental Toxicology, EarlyView.
ABSTRACT The effluents generated during the process of hair dyeing exhibit a complex composition, comprising chemical compounds with varying toxicity levels. While the adverse impact of hair dyes on human health is acknowledged, there is a notable absence of studies addressing the toxicity associated with effluents produced during these activities. The
Letícia Cristina Gonçalves, Matheus Mantuanelli Roberto, Adriana Fabiana Corrêa da Silva, Maria Aparecida Marin‐Morales   +3 more
wiley   +1 more source

Integrating mass spectrometry and systems biology for the modernization of natural medicines: From deciphering chemical complexity to holistic efficacy assessment

VIEW, EarlyView.
This review explores how mass spectrometry is transforming research in natural medicines, with Traditional Chinese medicine (TCM) as a primary exemplar. It details the application of advanced mass spectrometry in chemical analysis, the development of comprehensive quality control methods, and systematic research on the targeted mechanisms of single ...
Yudian Xu, Linlin Cao, Chenhuan Ding, Chen Wang, Yi Lai, Dan Ru, He Li, Wei Xu   +7 more
wiley   +1 more source

Both forest cover and land management practices explain variation in recovering pine marten densities

Wildlife Biology, EarlyView.
Robust monitoring of wildlife populations to guide interventions is fundamental to conservation and wildlife management. Understanding how landscape characteristics are influencing predator population dynamics is often vital to inform recovery strategies, management, and policy. The pine marten Martes martes is recovering in the UK; however, population
Keziah J. Hobson, Chris Sutherland, Cristian Navarro Waggershauser, Deborah A. Dawson, Gavin J. Horsburgh, Lucy S. Knowles, Xavier Lambin   +6 more
wiley   +1 more source

A reappraisal of the Middle to Later Stone Age prehistory of Morocco Réévaluer la préhistoire du Maroc, du Middle Stone Age au Later Stone Age

Journal of the Royal Anthropological Institute, EarlyView.
Over the last 25 years, perceptions of the early prehistory of Northwest Africa have undergone radical changes due to new fieldwork projects and a corresponding growth in scientific interest in the region. Much of this work has been focused in Morocco, known for its extremely rich fossil and archaeological records in caves and rock shelters.
Nick Barton, Abdeljalil Bouzouggar, Stacy Carolin, Louise Humphrey   +3 more
wiley   +1 more source

125 years of exploration and research at Gough's Cave (Somerset, UK) 125 ans d'exploration et de recherches à Gough's Cave (Somerset, Royaume‐Uni)

Journal of the Royal Anthropological Institute, EarlyView.
Our understanding of the recolonization of northwest Europe in the period leading up to the Lateglacial Interstadial relies heavily on discoveries from Gough's Cave (Somerset, UK). Gough's Cave is the richest Late Upper Palaeolithic site in the British Isles, yielding an exceptional array of human remains, stone and organic artefacts, and butchered ...
Silvia M. Bello, Mark D. Lewis, Simon A. Parfitt   +2 more
wiley   +1 more source

And then there was us Et puis nous sommes apparus

Journal of the Royal Anthropological Institute, EarlyView.
In 1987, the academic conference ‘Origins and Dispersals of Modern Humans: Behavioural and Biological Perspectives’ was held in Cambridge, UK. Subsequently referred to as the ‘Human Revolution’ conference, this meeting brought together the most prominent academics working in the field of human origins, including archaeologists and palaeoanthropologists,
Emma E. Bird, Julia Galway‐Witham, Chris Stringer   +2 more
wiley   +1 more source