Results 181 to 190 of about 93,163 (299)

Reconstruction of the human peopling of Europe: a genetic insight

Annals of Human Biology, 2021
David Caramelli, Cosimo Posth, Olga Rickards   +2 more
doaj   +1 more source

Quick Analysis of Sedimentary Ancient DNA Using quicksand. [PDF]

Mol Biol Evol
Szymanski M, Visagie J, Romagné F, Meyer M, Kelso J.   +4 more
europepmc   +1 more source

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

Ancient DNA study provides clues to leprosy susceptibility in medieval Europe. [PDF]

Genome Biol
Romeyer-Dherbey JH, Caliebe A, Ӧzer O, da Silva NA, Mejía NM, Myburgh DA, Fuchs K, Pedersen DD, Boldsen J, Larsen LA, Seeberg L, Søvsø M, Rieger D, Prescher A, Nebel A, Krause-Kyora B.   +15 more
europepmc   +1 more source

Ancient DNA Analysis of Middle and Late Period Archaeological Fish Remains from Kamloops, British Columbia

, 2014
Thomas C.A. Royle
openalex   +1 more source

Functional characterization of 42 CK2α de novo variants associated with Okur‐Chung neurodevelopmental syndrome

The FEBS Journal, EarlyView.
Okur‐Chung neurodevelopmental syndrome (OCNDS) is a neurodevelopmental disorder associated with mutations in the gene coding for Protein kinase CK2α. In this work, 42 variants of CK2α associated with OCNDS were characterized in vitro. This included determination of catalytic activity and CK2α/CK2β‐interaction as well as an assessment of evolutionary ...
Alexander Gast, Christian Werner, Karsten Niefind, Joachim Jose   +3 more
wiley   +1 more source

Ancient DNA from shells reveals delayed genomic erosion and rapid immune adaptation in the critically endangered black abalone. [PDF]

Proc Natl Acad Sci U S A
Wooldridge TB, Kapp JD, Ford SM, Seligmann WE, Conwell HC, Tzadikario T, Oppenheimer J, Anderson ZG, Le Moan A, Abadía-Cardoso A, Raimondi P, Shapiro B.   +11 more
europepmc   +1 more source

Caffeylpyruvate hydrolase from the bioluminescent fungus Neonothopanus gardneri is the key recycling enzyme in the fungal bioluminescence pathway

The FEBS Journal, EarlyView.
Caffeic acid is a central metabolite in the fungal bioluminescence pathway. We identified and characterized caffeylpyruvate hydrolase from Neonothopanus gardneri (ngarCPH) and demonstrate its ability to hydrolyze fungal oxyluciferin into caffeic and pyruvic acids, confirming a complete and self‐sustained fungal bioluminescence cycle.
Caio K. Zamuner, Douglas M. M. Soares, Bianca B. Nóbrega, Etelvino J. H. Bechara, Zinaida M. Kaskova, Alexander S. Mishin, Karen S. Sarkisyan, Ilia V. Yampolsky, Cassius V. Stevani   +8 more
wiley   +1 more source

At the Crossroads of Continents: Ancient DNA Insights into the Maternal and Paternal Population History of Croatia. [PDF]

Genes (Basel)
Marjanović D, Šarac J, Havaš Auguštin D, Novak M, Bašić Ž, Kružić I, Novokmet N, Cheronet O, Gelabert P, Pinhasi R, Lauc G, Primorac D.   +11 more
europepmc   +1 more source

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, EarlyView.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source