Results 181 to 190 of about 2,093,063 (290)

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

Harnessing archaeogenetic for cancer therapy: bridging ancient DNA insights with modern therapeutic innovations. [PDF]

Clin Epigenetics
Antal S, Sakthivel S, Goswami PK, Kumar D, Kondaveeti SB.   +4 more
europepmc   +1 more source

Functional characterization of 42 CK2α de novo variants associated with Okur‐Chung neurodevelopmental syndrome

The FEBS Journal, EarlyView.
Okur‐Chung neurodevelopmental syndrome (OCNDS) is a neurodevelopmental disorder associated with mutations in the gene coding for Protein kinase CK2α. In this work, 42 variants of CK2α associated with OCNDS were characterized in vitro. This included determination of catalytic activity and CK2α/CK2β‐interaction as well as an assessment of evolutionary ...
Alexander Gast, Christian Werner, Karsten Niefind, Joachim Jose   +3 more
wiley   +1 more source

ChASM: a statistically rigorous method for the detection of chromosomal aneuploidies in ancient DNA studies. [PDF]

Bioinformatics
Rohrlach AB, Tuke J, Prüfer K, Haak W.
europepmc   +1 more source

Caffeylpyruvate hydrolase from the bioluminescent fungus Neonothopanus gardneri is the key recycling enzyme in the fungal bioluminescence pathway

The FEBS Journal, EarlyView.
Caffeic acid is a central metabolite in the fungal bioluminescence pathway. We identified and characterized caffeylpyruvate hydrolase from Neonothopanus gardneri (ngarCPH) and demonstrate its ability to hydrolyze fungal oxyluciferin into caffeic and pyruvic acids, confirming a complete and self‐sustained fungal bioluminescence cycle.
Caio K. Zamuner, Douglas M. M. Soares, Bianca B. Nóbrega, Etelvino J. H. Bechara, Zinaida M. Kaskova, Alexander S. Mishin, Karen S. Sarkisyan, Ilia V. Yampolsky, Cassius V. Stevani   +8 more
wiley   +1 more source

Ancient DNA

NEXUS: The Canadian Student Journal of Anthropology, 1996
Bernd Herrmann, Suzanne Hummel
openaire   +4 more sources

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, EarlyView.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

Ancient DNA unravels the history of chickens in the Baltic Sea region and the continuity of landrace lineages. [PDF]

Heredity (Edinb)
Olli S, Gustavsson R, Kivikero H, Lõugas L, Mannermaa K, Piličiauskienė G, Rannamäe E, Searle JB, Kvist L, Honka J.   +9 more
europepmc   +1 more source

A 40‐year‐old woman with a spinal mass

Brain Pathology, EarlyView.
Melissa Mejia‐Bautista, Margarita Loxas, Pouya Jamshidi, Drew Duckett, Jean‐Paul Wolinsky, Jared T. Ahrendsen   +5 more
wiley   +1 more source

Alternative [2Fe‐2S] donor assemblies in the cytosol: GLRX3 and GLRX3‐BOLA2 converge on NUBP1 maturation

The FEBS Journal, EarlyView.
GLRX3 homodimer and GLRX3‐BOLA2 heterotrimer act as alternative [2Fe‐2S] donor assemblies for NUBP1 maturation. Both systems support formation of [4Fe‐4S] cluster‐bound NUBP1, but display distinct kinetic dependence on the physiological electron donor anamorsin, which accelerates GLRX3‐mediated transfer but does not enhance GLRX3‐BOLA2‐mediated ...
Martina Masini, Rosanna Cuccaro, Lucia Banci   +2 more
wiley   +1 more source