Results 161 to 170 of about 4,145,476 (300)

Navigating the energy transition: Identifying critical success factors for ancillary services provision and sustainable energy solutions in Germany. [PDF]

Heliyon
Gerlach J, Beutel V, Wegkamp C, Breitner MH, Geißendörfer S, Engel B, von Maydell K.   +6 more
europepmc   +1 more source

Arthroscopic Stabilization of the Hypermobile Lateral Meniscus Using an All‐Inside Repair Technique

Arthroscopy Techniques, EarlyView.
Abstract The hypermobile lateral meniscus is an uncommon cause of posterolateral knee pain and mechanical symptoms that often escapes standard imaging and is best confirmed by arthroscopy. A clinical stress maneuver combining knee flexion, valgus stress, and external rotation is described in this Technical Note as a simple adjunct to reproduce symptoms
Alberto Grassi, Tosca Cerasoli, Vito Gaetano Rinaldi, Giulio Maria Marcheggiani Muccioli, Claudio Rossi, Stefano Zaffagnini   +5 more
wiley   +1 more source

Unmet Needs for Ancillary Services and Associations with Clinical Outcomes Among Transgender Women with Diagnosed HIV: Medical Monitoring Project, United States, 2015-2020. [PDF]

LGBT Health
Espinosa CC, Crim SM, Carree T, Dasgupta S.   +3 more
europepmc   +1 more source

Arthroscopic Diagnosis and All‐Inside Repair of Meniscofibular Ligament Tear

Arthroscopy Techniques, EarlyView.
Abstract Meniscofibular ligament (MFL) tears are an under‐recognized source of lateral meniscal instability, frequently encountered in association with anterior cruciate ligament injury. Failure to identify and address MFL insufficiency may result in persistent posterolateral pain and meniscal hypermobility despite successful anterior cruciate ligament
Alberto Grassi, Tosca Cerasoli, Vito Gaetano Rinaldi, Claudio Rossi, Giulio Maria Marcheggiani Muccioli, Stefano Zaffagnini   +5 more
wiley   +1 more source

Optimization of pharmaceutical research and development by early‐phase assessment of investigational medicinal products

British Journal of Clinical Pharmacology, EarlyView.
Small and mid‐sized pharmaceutical innovators often have limited in‐house health economics and market access expertise, and may struggle to align development strategies of investigational medicinal products with health system needs and payer expectations.
Zoltán Kaló, Attila Imre, Gábor Varga, Sándor Kovács, György Tímár, Balázs Nagy   +5 more
wiley   +1 more source

Efficacy and safety of empagliflozin for treating neutropenia and neutrophil dysfunction in paediatric patients with glycogen storage disease type Ib: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Glycogen storage disease type Ib (GSD‐Ib) is a rare genetic disorder causing neutropenia and neutrophil dysfunction in children. G‐CSF has been the primary treatment, but emerging data support the potential of empagliflozin, an SGLT2 inhibitor, as a promising investigational option.
Elizabeth Iwasyk, Ryan Jin, Fabio Tuzzolino, Giusy Ranucci, Donatella Madonia, Alessio Provenzani   +5 more
wiley   +1 more source

Cost‐effectiveness of DPYD genotyping prior to fluoropyrimidine‐based treatment for colorectal cancer in Wales

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background Regulatory guidance in the United Kingdom advises DPYD genotyping prior to fluoropyrimidine‐based treatment. This economic evaluation estimated the costs and outcomes associated with DPYD screening prior to prescribing fluoropyrimidines for colorectal cancer in Wales and also considers additional variants to those included in ...
Catrin O. Plumpton, Sian M. Morgan, Richard A. Adams, Samantha Cox, Angharad A. Rudkin, Megan Fealey, Craig Barrington, Michelle D. Wood, Dyfrig A. Hughes   +8 more
wiley   +1 more source

Environmental impact of antidepressants: Is a new prescription framework possible?

British Journal of Clinical Pharmacology, EarlyView.
Aims Antidepressants such as venlafaxine and sertraline pose high risks to water ecosystems. As depressive disorders and other mental health conditions become increasingly prevalent worldwide, prescription and environmental presence of these pharmaceuticals continue to rise. This study explores the practical viability of a new framework for prescribing
Matilde Bianconi, Valentina Giunchi, Michael Thiede, Elisa Sangiorgi, Marco Menchetti, Elisabetta Poluzzi   +5 more
wiley   +1 more source

Benzodiazepines use in primary care England: Prescribing patterns and adverse consequences

British Journal of Clinical Pharmacology, EarlyView.
Aims Benzodiazepines (BZDs) are commonly prescribed for anxiety and insomnia but carry risks such as dependence, adverse drug reactions (ADRs) and mortality. Despite deprescribing efforts, the influence of recent prescribing trends, COVID‐19 and adverse outcomes on prescribing patterns in England remains uncertain.
Alvina Chaudhry, Muhammad Umair Khan, Barbara Conway, Syed Shahzad Hasan   +3 more
wiley   +1 more source

Ferritin as a Nanoparticle Scaffold for Plant‐Produced Next‐Generation Subunit Vaccines

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Protein nanoparticles offer an innovative approach to next‐generation subunit vaccine development by displaying antigenic sequences on the nanoparticle surface. Compared to traditional subunit vaccines, protein nanoparticle vaccines often show improved interaction with the immune system due to their particulate size and repetitive epitope ...
Jordan T. VanderBurgt, Richard Strasser, Christopher P. Garnham, Rima Menassa   +3 more
wiley   +1 more source