Results 91 to 100 of about 379,136 (292)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Conduct Problems in Children and Adolescents: Evidence in Brazil

Revista de Psicologia da IMED, 2019
The current study presents a systematic review of the national literature on Disruptive, Impulse-Control, and Conduct Disorders (DICCD) in Brazilian children and adolescents.
Guilherme Welter Wendt, Silvia Koller
doaj   +1 more source

Clinical Characteristics of Personality and Conduct Disorders in Child Patients With Vasovagal Syncope: A Clinical Case-Control Study. [PDF]

Front Pediatr, 2021
Wang T, Wang F, Li Y, Shi X, Duan H, Zhou K, Hua Y.   +6 more
europepmc   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Psychosocial correlates of recidivism in a sample of ex-prisoners: the role of Oppositional Defiant Disorder and Conduct Disorder

, 2014
The present study aimed to (a) examine the role of Oppositional Defiant Disorder and Conduct Disorder in predicting recidivism, while controlling for childhood arrest, perceived neighbourhood crime frequency, alcohol consumption, age, and gender, and (b)
Dhingra, Katie, Daniel Boduszek, Rachel Belsher, Katie Dhingra, Belsher, Rachel, Maria Ioannou, Boduszek, Daniel, Ioannou, Maria   +7 more
core   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Comparison of thyroid-stimulating hormone levels in adolescents with schizophrenia, bipolar disorder, unipolar depression, conduct disorders, and hyperkinetic disorders. [PDF]

Medicine (Baltimore), 2021
Makarow-Gronert A, Margulska A, Strzelecki D, Krajewska K, Gmitrowicz A, Gawlik-Kotelnicka O.   +5 more
europepmc   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Breastfeeding and behavior disorders among children and adolescents: a systematic review

Revista de Saúde Pública, 2018
OBJECTIVE This systematic review study aimed to assess the evidence available for the association between breastfeeding and behavior disorders in childhood and adolescence. METHODS The search was carried out in the PubMed, Lilacs, and PsycINFO databases
Wanêssa Lacerda Poton, Ana Luiza Gonçalves Soares, Elizabete Regina Araújo de Oliveira, Helen Gonçalves   +3 more
doaj   +1 more source