Results 131 to 140 of about 379,136 (292)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Hopelessness and temperament of youth in residential treatment [PDF]

, 2000
Plan BThe importance of hopelessness and temperament within the study of youth psychiatric disorders is becoming increasingly apparent. Analysis of these two constructs further elucidates the factors that are correlated with psychopathology in children ...
McKenney, Jackie
core  

Minnesota Multiphasic Personality Inventory-adolescent-restructured Form (MMPI-A-RF): Characteristics of Conduct Disorder [PDF]

Journal of Rehabilitation
Objective Disruptive and conduct behaviors are the most common conditions used to help adolescent patients refer to mental health clinics for counseling. The prevalence of this disorder is increasing and it is necessary to concentrate on this topic.
Marzieh Norozpour, Abbas Pourshahbaz, Hamid Poursharifi, Behrooz Dolatshahi, Nastaran Habibi   +4 more
doaj  

The relationship between callous-unemotional traits and internalizing psychopathology in adolescent psychiatric inpatients: a network analysis

Child and Adolescent Psychiatry and Mental Health
Background Numerous studies have investigated the relevance of callous-unemotional traits in relation to externalizing psychopathology among children and adolescents.
Laura Maria Derks, Eni Sabine Becker, Wolf-Gero Lange, Mike Rinck, Anna Lena Dapprich, Martin Holtmann, Tanja Legenbauer   +6 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

RELATIONSHIPS BETWEEN SOCIAL PHOBIA AND SUBSTANCE USE DISORDERS AMONG YOUTH: MODERATING EFFECTS OF CONDUCT DISORDER AND GENDER

, 2011
between social phobia and substance use disorders among youth: Moderating effects of conduct disorder and ...
Margaret Coleman, Coleman, Margaret
core   +1 more source

The impact of pre- and perinatal factors on attention-deficit and disruptive behavior disorders

The Turkish Journal of Pediatrics, 2001
Diagnosis of attention-deficit and disruptive behavior disorders defines a group of disorders which have common properties. This group consists of attention-deficit hyperactivity disorder, conduct disorder and oppositional defiant disorder.
S Senol, S Sener, E Ergenekon, K Gücüyener   +3 more
doaj  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source