Results 121 to 130 of about 379,136 (292)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Plasma Risperidone-related Measures in Children and Adolescents with Oppositional Defiant/Conduct Disorders. [PDF]

Clin Psychopharmacol Neurosci, 2020
Piacentino D, Kotzalidis GD, Schoretsanitis G, Paulzen M, Haen E, Cappelletti S, Giupponi G, Grözinger M, Conca A.   +8 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Family factors associated with conduct disorders in Children and Adolescents. [PDF]

, 2011
INTRODUCTION : Conduct disorder is a disorder initially diagnosed in childhood or adolescence and refers to a persistent pattern of antisocial behavior in which the individual repeatedly breaks social rules and carries out aggressive acts that upset ...
Priya Mary, Mammen
core  

Conduct disorders among adolescents in te context of socialization [PDF]

, 2008
This thesis is discussing conduct disorders among children and adolescents. The goal of this thesis is to map risk and dangerous factors and their influence in a context of socialization and look into its nature in relation to their acts of behavior.
Kajuková, Věra
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

How Do Youth with Mental Disorders Fare in the Juvenile Justice System? [PDF]

The purpose of this paper is to examine the relationship between mental health problems and justice outcomes. Several studies have documented that individuals with a variety of mental disorders are overrepresented in the justice system.
Alison Cuellar, Pinka Chatterji
core  

Oppositional and conduct disorders

, 2015
Oppositional defiant and conduct disorders refer to persistent antisocial and aggressive behavior that is outside socially acceptable norms. Considerable advances have been made in recent years in understanding different subtypes and their trajectories ...
Scott, Stephen, Stephen Scott
core   +1 more source

A Rating Scale to Differentiate between Conduct Disorder and Attention Deficit Hyperactivity Disorder

مجله دانشکده پزشکی اصفهان, 2009
Background: The symptoms of conduct disorder and ADHD (attention deficit hyperactivity disorder) have many overlaps. These two disorders are considered to be the two most common psychiatric disorders among school aged children.
Sayed Jalal Sadrossadat, Zahra Hooshyari, Leila Sadrossadat, Akbar Rouzbahani, Majid Ghias, Masoud Nikfarjam   +5 more
doaj  

الفروق بين مرضي اضطربات المسلك والاسوياء في تنظيم الذات والادخار المعرفي والتعقل

Al-Mağallah Al-ʿilmiyyaẗ Li Kulliyyaẗ Al-Adāb - Ǧāmiʿaẗ Asyūṭ
هدفت البحث الراهن إلي الوقوف علي الفروق بين مريضات اضطراب المسلك و السويات في التعقُّل وتنظيم الذات والإدخار المعرفي . وقد تكونت عينة البحث من (40) مريضة من مريضات اضطرابات المسلك و (40) مشاركة من السويات ، وقد تراوحت أعمارهن بين 12 إلي 17 سنة، وتم ...
دينا عنتر شعيب
doaj   +1 more source