Results 161 to 170 of about 4,449,758 (301)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Technological Advances and Information Science

American Journal of Men's Health, 2013
Demetrius J. Porche DNS, PhD, FAANP, FAAN
doaj   +1 more source

O ensino com a prática da pesquisa: delineamento de uma nova proposta de formaçáo

Transinformação
Discute a necessidade de introduzir uma nova concepção de ensinar e aprender na universidade, pautada pela articulação entre ensino e pesquisa. Considera que essa concepção pode ser viabilizada no âmbito do ensino de Biblioteconomia e Ciência da ...
Mara Eliane Fonseca Rodrigues, Esther Hermes Lück, Vera Lúcia Alves Breglia   +2 more
doaj  

In Memoriam: Lynn C. Westney (1947-2021)

Names, 2021
I. M. Nick
doaj   +1 more source

The Quantum Information Science Challenge for Chemistry. [PDF]

J Phys Chem Lett
Scholes GD, Olaya-Castro A, Mukamel S, Kirrander A, Ni KK, Hedley GJ, Frank NL.   +6 more
europepmc   +1 more source

Incorporating Geographic Information Science and Technology in Response to the COVID-19 Pandemic. [PDF]

Prev Chronic Dis, 2020
Smith CD, Mennis J.
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Novel extensions of k-harmonically convex functions and their applications in information science. [PDF]

PLoS One
Fahad A, Furuichi S, Ali Z, Wang Y.
europepmc   +1 more source

Journal of Information Science Theory and Practice [PDF]

, 2019
Korea Institute of Science and Technology Information
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source