Results 81 to 90 of about 3,269,462 (303)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Advancing our cities and regions strategy [PDF]
The Advancing our cities and regions strategy is an innovative approach to renewing and repurposing surplus and underutilised state property to deliver better community outcomes, create jobs and drive economic growth.
Department of Infrastructure +1 more
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Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Infrastructure, transport and productivity [PDF]
This information sheet reviews trends in Australian productivity with a focus on the transport sector. Well targeted investments in transport infrastructure result in productivity increases that benefit many other industries.
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Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Integrated Infrastructure Modelling — Managing Interdependencies with a Generic Approach [PDF]
, 2015 Infrastructure provision is a highly challenging task, especially when accounting for climate change mitigation and adaptation needs. Efforts of making infrastructure more efficient and flexible result in an increasing number of sensitive ...
Dirks, B.R., Hall, J.W., Otto, A.
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Aging and Cancer, EarlyView.ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source
Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham +7 more
wiley +1 more source
Civil Engineering Dimension, 2019 A series of three reinforced concrete beams without shear reinforcement were tested to failure under a centre-span monotonic load, a centre-span pulsating load, and a stepwise-moving pulsating load.
Benny Suryanto, George Staniforth
doaj +3 more sources
Interpreting the impact of flood forecasts by combining policy analysis studies and flood defence
E3S Web of Conferences, 2016 Flood forecasting is necessary to save lives and reduce damages. Reducing damages is important to save livelihoods and to reduce the recovery time. Flood alerts should contain expected time of the event, location and extent of the event. A flood alert is
Slomp Robert +4 more
doaj +1 more source