Results 61 to 70 of about 3,269,462 (303)

A guide and toolkit: green infrastructure [PDF]

open access: yes, 2008
Toolkit to support the development and implementation of projects aimed at enhancing or protecting green infrastructure. Provides a rationale for investment in green infrastructure and an evaluation framework for assisting learning and decision ...
Amion Consulting
core  

Enhancing Infrastructure Resilience Under Conditions of Incomplete Knowledge of Interdependencies [PDF]

open access: yes, 2015
Today’s infrastructures — such as road, rail, gas, electricity and ICT — are highly interdependent, and may best be viewed as multi-infrastructure systems. A key challenge in seeking to enhance the resilience of multi-infrastructure systems in practice
Bollinger, L.A., Dijkema, G.P.J.
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Infrastructure, the crisis, and pension funds [PDF]

open access: yes, 2009
Infrastructure investment has been an important element in the economic stimulus packages introduced to try and deal with the effects of the recession.
Hall, David
core  

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

open access: yesMolecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor   +2 more
wiley   +1 more source

Narrating National Geo Information Infrastructures: Balancing Infrastructure and Innovation

open access: yesJournal of Service Science and Management, 2009
This paper examines narratives relating to the development of National Geo Information Infrastructures (NGII) in ethnographic research on a Dutch NGII project which was monitored throughout its course. We used an approach which focuses on narratives concerning the environment, groups and practice to elicit sense-making processes.
Koerten, H. (author)   +1 more
openaire   +4 more sources

Portfolio Infrastructure Investments: an Analysis of the European and UK Cases [PDF]

open access: yes, 2015
Infrastructure has been receiving much attention in recent years. Investment banks and fund managers are increasingly promoting the investment characteristics of infrastructure assets and they argue that investing in infrastructure should be ideal for ...
Medda, F, Panayiotou, A
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

The Role of Futureproofing in the Management of Infrastructural Assets [PDF]

open access: yes, 2015
Ensuring long-term value from infrastructure is essential for a sustainable economy. In this context, futureproofing involves addressing two broad issues: i.
Masood, T.   +3 more
core  

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

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