Results 61 to 70 of about 881,645 (296)

Epidemiology of hand, foot and mouth disease in China, 2008 to 2015 prior to the introduction of EV-A71 vaccine

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2017
Introduction Hand, foot and mouth disease (HFMD) is usually caused by several serotypes from human enterovirus A species, including enterovirus 71 (EV-A71) and coxsackievirus A16 (CV-A16).
Bingyi Yang, Fengfeng Liu, Q. Liao, Peng Wu, Z. Chang, Jiao Huang, L. Long, L. Luo, Yu Li, G. Leung, B. Cowling, Hongjie Yu   +11 more
semanticscholar   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Role of word-of-mouth for programs of voluntary vaccination: A game-theoretic approach [PDF]

, 2015
We propose a model describing the synergetic feedback between word-of-mouth (WoM) and epidemic dynamics controlled by voluntary vaccination. We combine a game-theoretic model for the spread of WoM and a compartmental model describing $SIR$ disease ...
Bauch, Chris, Bhattacharyya, Samit, Breban, Romulus   +2 more
core   +2 more sources

Emerging Enteroviruses Causing Hand, Foot and Mouth Disease, China, 2010–2016

Emerging Infectious Diseases, 2018
Coxsackievirus A6 emerged as one of the predominant causative agents of hand, foot and mouth disease epidemics in many provinces of China in 2013 and 2015.
Yu Li, Z. Chang, Peng Wu, Q. Liao, Fengfeng Liu, Yaming Zheng, L. Luo, Yonghong Zhou, Qi Chen, Shuan-bao Yu, Chun Guo, Zhenhua Chen, L. Long, Shanlu Zhao, Bingyi Yang, Hongjie Yu, B. Cowling   +16 more
semanticscholar   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Scenarios for eradicating foot-and-mouth disease [PDF]

Research project commissioned by the Ministery of Agriculture, Nature Management and Fisheries. With the help of desk-research and input-output analysis quantitative information is assembled about the differences in cost for agribusiness and tourism of ...
Bos, E.J., Leeuwen, M.G.A., van, Vlieger, J.J., de   +2 more
core   +1 more source

Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus

Nature Communications, 2017
Foot-and-mouth disease virus (FMDV) mediates cell entry by attachment to an integrin receptor, generally αvβ6, via a conserved arginine–glycine–aspartic acid (RGD) motif in the exposed, antigenic, GH loop of capsid protein VP1.
A. Kotecha, Quan Wang, Xianchi Dong, S. Ilca, M. Ondiviela, Rao Zihe, J. Seago, B. Charleston, E. Fry, N. Abrescia, T. Springer, J. Huiskonen, D. Stuart   +12 more
semanticscholar   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

HAND-FOOT-AND-MOUTH-DISEASE (HFMD) [PDF]

, 2016
Bolest šaka, stopala i usta je akutna zarazna bolest karakterizirana vrućicom, vezikularnim lezijama u ustima te osipom na dlanovima, tabanima i/ili genitalnom području. U većini slučajeva HMFD je uzročnik Coxsackie A virus tip 16.
Kristina Sambol, Tamara Bosak, Tatjana Cikač   +2 more
core   +1 more source