Results 111 to 120 of about 8,489,039 (291)
Argumentation and Epistemic Criteria: Investigating Learners’ Reasons for Reasons
The dominant practices in science are not discovery and justification but rather the broadening and deepening of explanations via theory development and conceptual modification. New tools, theories, and technologies are fundamentally changing the methods and inquiry practices of science.
Richard Duschl, Kirsten Ellenbogen
openaire +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
The role and implications of mammalian cellular circadian entrainment
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Julie F McClelland,1 Lynne Bodle,1,2 Julie-Anne Little11Vision Science Research Group, Biomedical Sciences Research Institute, Ulster University, Coleraine, UK; 2Department of Ophthalmology, Flinders Medical Centre, Flinders University, Adelaide, SA ...
McClelland JF, Bodle L, Little JA
doaj
Shane Khan,1 Karen Sohan,2 Zada CM Mohammed,3 Vishal Bachan4 1Obstetrics and Gynaecology Unit, Department of Clinical Surgical Sciences, Faculty of Medical Sciences, University of the West Indies, St. Augustine Campus, St. Augustine, Trinidad and Tobago;
Khan S, Sohan K, Mohammed ZCM, Bachan V
doaj
Molecular bases of circadian magnesium rhythms across eukaryotes
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Krzysztof Buczkowski,1 Ludmila Marcinowicz,2 Slawomir Czachowski,1 Elwira Piszczek3 1Department of Family Medicine, Collegium Medicum, Nicolaus Copernicus University, Torun, 2Department of Family Medicine and Community Nursing, Medical University of ...
Buczkowski K +3 more
doaj
Krzysztof Buczkowski,1 Magdalena Dachtera-Frąckiewicz,1 Dorota Luszkiewicz,1 Katarzyna Klucz,1 Jolanta Sawicka-Powierza,2 Ludmila Marcinowicz3 1Department of Family Medicine, Nicolaus Copernicus University, Torun, Poland; 2Department of Family ...
Buczkowski K +5 more
doaj
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Shane Khan,1 Karen Sohan,2 Zada CM Mohammed,3 Vishal Bachan4 1Department of Clinical Surgical Sciences, University of the West Indies, St. Augustine, Trinidad and Tobago; 2Diagnostic Mother and Baby (Private Sector), Chaguanas, Trinidad and Tobago ...
Khan S, Sohan K, Mohammed ZCM, Bachan V
doaj

