Rad51 at the Crossroads: Bridging DNA Repair, Tumorigenesis, and Immune Regulation
Med Research, EarlyView.Therapeutic landscape of Rad51 in cancer treatment. Key elements include (1) DNA damage sources (PARPi, chemo/radiotherapy); (2) repair pathways (Rad51‐mediated HR); (3) intervention strategies (Rad51 inhibitors, CRISPR/Cas9); and (4) combination approaches (immunotherapy). The figure is created with BioRender.com.
Zhendong Qin +4 more
wiley +1 more source
Harm reduction measures in a recreational gym user with anabolic androgenic steroid dependence: a case report in the context of current best clinical practice. [PDF]
Harm Reduct JMagnolini R +5 more
europepmc +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Targeted radioligand therapy has emerged as a promising treatment option for eradicating advanced cancer forms. α‐Emitters are considered particularly promising as they can obliterate (micro)‐metastases. The α‐emitter astatine‐211 (211At) has experienced increased interest due to its favorable decay properties.
Marius Müller +5 more
wiley +1 more source
Toxicities of novel androgen receptor pathway inhibitor targeted therapies in advanced prostate cancer. [PDF]
Curr Opin UrolIaxx R +4 more
europepmc +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi +2 more
wiley +1 more source
Efficacy and Safety of Combination Androgen-Receptor Signaling Inhibitors, Denosumab, and Local Radiotherapy for Poly-Metastatic Prostate Cancer. [PDF]
Cancer Rep (Hoboken)Kawase M +5 more
europepmc +1 more source
Molecular Nutrition &Food Research, EarlyView.Male and female mice were fed different diets for up to 24 weeks to study the effects of phytosterols (PS) on weight gain and brain immune cells. PS reduced weight gain in HFD‐fed mice. Microglia were isolated from brains and analyzed, revealing no diet‐driven inflammation changes, but differences based on sex and age.
Laura Plantera +7 more
wiley +1 more source
Role of Gynecologic Findings in Interstitial Cystitis/Bladder Pain Syndrome: A Consensus
Neurourology and Urodynamics, EarlyView.ABSTRACT Objective To evaluate the role of gynecologic findings in Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) by reviewing current international guidelines and identifying relevant gynecologic co‐morbidities. Methods This consensus statement was developed through a systematic four‐phase process: (1) comprehensive literature review across ...
Marie E. Sullivan +5 more
wiley +1 more source
Mechanisms of neuroendocrine differentiation in castration-resistant prostate cancer and advances in the treatment of neuroendocrine prostate cancer. [PDF]
Ann MedShao B, Zeng Y.
europepmc +1 more source