Results 61 to 70 of about 89,384 (157)

A novel de novo androgen receptor nonsense mutation in a sex-reversed 46,XY infant

Human Genome Variation, 2021
An infant with 46,XY karyotype, and unambiguous female phenotype was found to have testes in the inguinal regions. Capillary sequencing of the androgen receptor (AR) gene identified a hemizygous de novo mutation (NM_000044.6:c.1621G > T) in exon 2 ...
Kok-Siong Poon, Karen Mei-Ling Tan, Kah Yin Loke   +2 more
doaj   +1 more source

Cancer Expenditures and Mortality Trends in Brazil: An Ecological Population‐Level Time‐Series Analysis, 2008–2023

Cancer Medicine, Volume 15, Issue 9, September 2026.
Schematic representation of the temporal relationship between increasing SUS‐recorded expenditures for breast and prostate cancer care in Brazil and comparatively limited changes in age‐standardized mortality, highlighting the potential influence of diagnostic delays, unequal access, healthcare infrastructure, and major oncology policy milestones.
Larissa Saldanha Fonseca, Leonardo Paredes Pires, Luciana Magalhães Rebelo Alencar, Eduardo Ricci‐Junior, Ralph Santos‐Oliveira   +4 more
wiley   +1 more source

Complete androgen insensitivity syndrome: A case report

Journal of Dr. NTR University of Health Sciences, 2019
Technology cannot replace clinical acumen. Think of complete androgen insensitivity syndrome (CAIS) in a female child with inguinal hernia. Diagnosis was missed in our patient when she presented with inguinal hernia the first time.
Suresh K Jariwala
doaj   +1 more source

Deciphering the Medicinal Chemistry Aspects of Akt Inhibitors for the Management of Cancer: Structure–Activity Relationship Frameworks, Landscapes, and Optimization Approaches

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
This review majorly describes the systematic development of Akt inhibitors involving numerous heterocyclic scaffolds along with their structure activity relationships to explore anticancer therapeutic strategies. ABSTRACT The Akt pathway is dysregulated in cancer, leading to proliferation, decreased apoptosis, and metastasis, and hence is a major ...
Mayur S. Dhangar, Mahesh B. Palkar
wiley   +1 more source

Survival Outcomes With Cadonilimab Versus PD‐(L)1 Therapy in Front‐Line Gastric Cancer: A Network Meta‐Analysis

Cancer Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background The FDA Oncologic Drugs Advisory Committee (ODAC) highlighted that the risk–benefit profile for patients with low PD‐L1 expression remains unclear in front‐line treatment of HER2‐negative gastric and gastroesophageal junction (GC/GEJ) cancer with PD‐(L)1 therapy.
Zi‐Kun Yu, Jia‐Hong Yi, Ju Xue, Yu‐Chen Huang, Yue Zhao, Chang Jiang, Chen‐Xi Yin, Biao Xia, Yi‐Xin Zhou, Wen‐Zhuo He, Liang‐Ping Xia   +10 more
wiley   +1 more source

Insensibilidade androgênica completa e hérnia inguinal: relato de 3 casos. [PDF]

, 1999
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Departamento de Pediatria, Curso de Medicina, Florianópolis ...
Queirós, Raquel Campos Galvão de
core  

Comprehensive androgen-dependent transcriptome analysis in human genital tissue

BMC Genomics
Background Androgen signalling through the androgen receptor (AR) is crucial for male genital development. Disruptions in this pathway are associated with androgen insensitivity syndrome (AIS), which is typically caused by mutations in the AR gene ...
Radhika Sivaprasad, Kristian Händler, Almuth Caliebe, Malte Spielmann, Paul-Martin Holterhus, Nadine C. Hornig   +5 more
doaj   +1 more source

A Two‐Stage Hybrid Feature Selection and Ensemble Learning Framework With Explainable AI for Accurate PCOS Prediction

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Polycystic ovary syndrome (PCOS) is the most prevalent endocrine ailment impacting women of reproductive age, distinguished by ongoing imbalances of hormones that lead to the growth of various ovarian cysts alongside other health issues.
Md. Rakibul Hasan Efty, Md. Naymur Rohman, Khandaker Mohammad Mohi Uddin, Md. Mahbubur Rahman, Md. Ashraf Uddin   +4 more
wiley   +1 more source

Three novel mutations in the androgen receptor gene associated with partial androgen insensitivity syndrome: H570R, G589E and S759T [PDF]

Einstein (São Paulo), 2003
Three novel mutations in the androgen receptor gene were detectedby PCR-SSCP and characterized by DNA sequencing of genomicDNA samples from 3 unrelated patients with male pseudohermaphroditism caused by partial androgen insensitivity.
Patrícia Renovato Tobo, Angela Silva Barbosa, Lene Garcia Barbosa, Angela Maria Spínola-Castro, Carlos Alberto Moreira-Filho   +4 more
doaj  

SLC3A1 Mitigates Ferroptosis and Promotes Enzalutamide Resistance in Prostate Cancer

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
SLC3A1 is a promising therapeutic target for advanced prostate cancer. ABSTRACT Prostate cancer (PCa) remains a leading cause of cancer‐related mortality in aging male, with resistance to enzalutamide (Enza) representing a major therapeutic challenge. This study identifies SLC3A1 as a key driver of Enza resistance.
Peng Liu, Haocheng Zhang, Yuhang Qian, Jiong Zhang, Xiaojun Deng, Bin Sun   +5 more
wiley   +1 more source