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The Role of Androgen Receptor Signaling in Ovarian Cancer
Cells, 2019 Emerging evidence has suggested that androgen receptor signaling plays an important role in ovarian cancer outgrowth. Specifically, androgen receptor activation appears to be associated with increased risks of developing ovarian cancer and inducing tumor
Taichi Mizushima, Hiroshi Miyamoto
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Frontiers in Endocrinology, 2022 Androgen receptor signaling pathway is necessary to complete spermatogenesis in testes. Difference between androgen binding location in Sertoli cell classifies androgen receptor signaling pathway into classical signaling pathway and non-classical ...
Jia-Ming Wang, Zhen-Fang Li, Wan-Xi Yang
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The androgen receptor/filamin A complex as a target in prostate cancer microenvironment
Cell Death and Disease, 2021 Prostate cancer represents the major cause of cancer-related death in men and patients frequently develop drug-resistance and metastatic disease. Most studies focus on hormone-resistance mechanisms related to androgen receptor mutations or to the ...
Marzia Di Donato +12 more
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Androgen receptor accelerates premature senescence of human dermal papilla cells in association with DNA damage. [PDF]
PLoS ONE, 2013 The dermal papilla, located in the hair follicle, expresses androgen receptor and plays an important role in hair growth. Androgen/Androgen receptor actions have been implicated in the pathogenesis of androgenetic alopecia, but the exact mechanism is not
Yi-Chien Yang +5 more
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Technology in Cancer Research & Treatment, 2021 Triple-negative breast cancer is a heterogeneous disease with different molecular and histological subtypes. The Androgen receptor is expressed in a portion of triple-negative breast cancer cases and the activation of the androgen receptor pathway is ...
Taobo Hu +3 more
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Androgen receptor status is a prognostic marker in non-basal triple negative breast cancers and determines novel therapeutic options. [PDF]
PLoS ONE, 2014 Triple negative breast cancers are a heterogeneous group of tumors characterized by poor patient survival and lack of targeted therapeutics. Androgen receptor has been associated with triple negative breast cancer pathogenesis, but its role in the ...
Pierluigi Gasparini +13 more
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Filamin A cooperates with the androgen receptor in preventing skeletal muscle senescence
Cell Death Discovery, 2023 Aging induces a slow and progressive decrease in muscle mass and function, causing sarcopenia. Androgens control muscle trophism and exert important anabolic functions through the binding to the androgen receptor.
Marzia Di Donato +7 more
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Does changing androgen receptor status during prostate cancer development impact upon cholesterol homeostasis? [PDF]
PLoS ONE, 2013 Recent evidence associates prostate cancer with high cholesterol levels, with cholesterol being an important raw material for cell-growth. Within the cell, cholesterol homeostasis is maintained by two master transcription factors: sterol-regulatory ...
James Robert Krycer, Andrew John Brown
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Pakistan Armed Forces Medical Journal, 2021 Objective: To determine the frequency of immunohistochemical expression of androgen receptor in triple negative breast carcinoma. Study Design: Cross sectional study.
Amna Ameer +3 more
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The effect of different types of hepatic injury on the estrogen and androgen receptor activity of liver [PDF]
, 1989 Mammalian liver contains receptors for both estrogens and androgens. Hepatic regeneration after partial hepatectomy in male rats is associated with a loss of certain male-specific hepatic characteristics.
Aten R. F. +24 more
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