Results 31 to 40 of about 210,919 (300)

Mechanism of antiandrogen action: Conformational changes of the receptor [PDF]

, 1994
Androgen receptor mRNA was translated in vitro, and androgen- and antiandrogen-bound receptor complexes were studied using limited proteolytic digestion by trypsin.
Kuil, C.W. (Cor), Mulder, E. (Eppo)
core   +1 more source

The Role of Androgen Receptor Signaling in Ovarian Cancer

Cells, 2019
Emerging evidence has suggested that androgen receptor signaling plays an important role in ovarian cancer outgrowth. Specifically, androgen receptor activation appears to be associated with increased risks of developing ovarian cancer and inducing tumor
Taichi Mizushima, Hiroshi Miyamoto
doaj   +1 more source

Negative regulation of the androgen receptor gene through a primate specific androgen response element present in the 5' UTR [PDF]

, 2014
Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
Hay, Colin W, Hunter, Irene, Lavery, Derek N, MacKenzie, Alasdair, McEwan, Iain J, Watt, Kate   +5 more
core   +2 more sources

Molecular cloning and characterization of a nuclear androgen receptor activated by 11-ketotestosterone

Reproductive Biology and Endocrinology, 2005
Although 11-ketotestosterone is a potent androgen and induces male secondary sex characteristics in many teleosts, androgen receptors with high binding affinity for 11-ketotestosterone or preferential activation by 11-ketotestosterone have not been ...
Karlsson Johnny, Larsson Anders, Hellqvist Anna, Grahn Birgitta, von Hofsten Jonas, Berg A Håkan, Olsson Per-Erik, Modig Carina, Borg Bertil, Thomas Peter   +9 more
doaj   +1 more source

Androgen receptor-dependent and -independent mechanisms driving prostate cancer progression: Opportunities for therapeutic targeting from multiple angles. [PDF]

, 2016
Despite aggressive treatment for localized cancer, prostate cancer (PC) remains a leading cause of cancer-related death for American men due to a subset of patients progressing to lethal and incurable metastatic castrate-resistant prostate cancer (CRPC).
Hoang, David T., Iczkowski, Kenneth A., Kilari, Deepak, Nevalainen, Marja T., See, William   +4 more
core   +2 more sources

In silico prediction of nuclear receptor binding to polychlorinated dibenzofurans and its implication on endocrine disruption in humans and wildlife

Current Research in Toxicology, 2021
Polychlorinated dibenzofurans (PCDFs) are known to cause endocrine disruption in humans and wildlife but the mechanisms underlying this disruption have not been adequately investigated.
Lukman K. Akinola, Adamu Uzairu, Gideon A. Shallangwa, Stephen E. Abechi   +3 more
doaj   +1 more source

The impact of point mutations in the human androgen receptor: classification of mutations on the basis of transcriptional activity.

PLoS ONE, 2012
Androgen receptor mediated signaling drives prostate cancer cell growth and survival. Mutations within the receptor occur infrequently in prostate cancer prior to hormonal therapy but become prevalent in incurable androgen independent and metastatic ...
Colin W Hay, Iain J McEwan
doaj   +1 more source

Effect of spironolactone and potassium canrenoate on cytosolic and nuclear androgen and estrogen receptors of rat liver [PDF]

, 1987
Spironolactone and potassium canrenoate are diuretics that are used widely for management of cirrhotic ascites. The administration of spironolactone frequently leads to feminization, which has been noted less frequently with the use of potassium ...
Alfredo Di Leo, Antonio Francavilla, Armanini, Aten, Bannister, Bellati, Boisselle, Bradford, Burton, Chopra, Clark, Duffy, Dupont, Eagon, Eagon, Eagon, Eagon, Farrell, Francavilla, Francavilla, Francavilla, Francesco Guglielmi, Fromatin, Giuseppe Fanizza, Greenblatt, Gustafsson, Gustafsson, Huffman, Kneifel, Lorenzo Polimeno, Loriaux, Marco, Menard, Michele Barone, Niewoehner, Norstedt, Patricia K. Eagon, Porter, Porter, Powell-Jones, Rifka, Rogerson, Scatchard, Serafini, Thomas E. Starzl, Turocy, Van Thiel   +46 more
core   +1 more source

Severe forms of partial androgen insensitivity syndrome due to p.L830F novel mutation in androgen receptor gene in a Brazilian family

BMC Research Notes, 2011
Background The androgen insensitivity syndrome may cause developmental failure of normal male external genitalia in individuals with 46,XY karyotype.
Guerra-Junior Gil, de Calais Flávia L, Soardi Fernanda C, Maciel-Guerra Andréa T, Petroli Reginaldo J, de Mello Maricilda   +5 more
doaj   +1 more source

Research Progress of Androgen/Androgen Receptor Signaling Pathway in Hepatocellular Carcinoma

Zhongliu Fangzhi Yanjiu, 2023
Hepatocellular carcinoma (HCC) is a kind of primary liver cancer with a high mortality rate. In China, the incidence ratio in males to females with HCC is 2:1–5:1.
WANG Ruihua, CAI Shiliang, LIU Donghong, CHEN Hongsen, CAO Guangwen   +4 more
doaj   +1 more source