Results 21 to 30 of about 210,919 (300)

Prognostic Value of Androgen Receptor Expression in Bladder Tumors [PDF]

Translational Research in Urology, 2023
Introduction: The present study was conducted with the aim of investigating the prognostic value of androgen receptor expression in bladder tumors.Methods: This study was conducted in the urology department of Imam Reza Hospital on male patients with ...
Salman Soltani, Sajjad Sadeghpour, Mahmood Reza Kalantari, Hamidreza Ghorbani, Majid Khadem Rezaiyan, Atena Aghaee, Mahmoud Tavakoli, Hamideh Heydari, Samira Assarian   +8 more
doaj   +1 more source

Effect of antiandrogen flutamide on measures of hepatic regeneration in rats [PDF]

, 1989
Male rat liver undergoes a process of demasculinization during hepatic regeneration following partial hepatectomy. The possibility that antiandrogens might potentiate this demasculinization process and in so doing augment the hepatic regenerative ...
A Francavilla, A Mode, A Schleusener, AE Pegg, AJ Syms, B Katchen, CL Mendenhall, CW Bardin, D Kahn, DM Cohen, E Bresnidk, E Mezey, E Mezey, E Mezey, EM Higgins, ER Lax, F Neumann, J Simard, J Terblanche, JA Gustafsson, JA Gustafsson, JA McGowan, JH Clark, JM Kissane, JP Blondeau, KE Crow, LE Porter, M Kayfman, M Sarff, MF Zuretti, OH Lowry, PK Eagon, PK Eagon, PK Eagon, R Neri, W Welshons, WJ King   +36 more
core   +1 more source

NON-GENOMIC ANDROGEN ACTION REGULATES PROLIFERATIVE/MIGRATORY SIGNALLING IN STROMAL CELLS.

Frontiers in Endocrinology, 2015
Prostate cancer is the major cause of cancer-related death among the male population of Western society, and androgen deprivation therapy represents the first line in prostate cancer treatment. However, although androgen receptor expression is maintained
Marzia eDi Donato, Pia eGiovannelli, Gustavo eCernera, Annalisa eDi Santi, Irene eMarino, Antonio eBilancio, Giovanni eGalasso, Ferdinando eAuricchio, Antimo eMigliaccio, Gabriella eCastoria   +9 more
doaj   +1 more source

An Sp1 Modulated Regulatory Region Unique to Higher Primates Regulates Human Androgen Receptor Promoter Activity in Prostate Cancer Cells [PDF]

, 2015
Funding: This work was supported by the Chief Scientist’s Office (CSO) of the Scottish Government (http://www.cso.scot.nhs.uk/): CWH (CZB-4-477) and IH (ETM/382).Peer reviewedPublisher ...
Hay, Colin W, Hunter, Irene, MacKenzie, Alasdair, McEwan, Iain J   +3 more
core   +3 more sources

Small extracellular vesicle-mediated ITGB6 siRNA delivery downregulates the αVβ6 integrin and inhibits adhesion and migration of recipient prostate cancer cells

Cancer Biology & Therapy, 2022
The αVβ6 integrin, an epithelial-specific cell surface receptor absent in normal prostate and expressed during prostate cancer (PrCa) progression, is a therapeutic target in many cancers.
Shiv Ram Krishn, Vaughn Garcia, Nicole M. Naranjo, Fabio Quaglia, Christopher D. Shields, Maisha A. Harris, Andrew V. Kossenkov, Qin Liu, Eva Corey, Dario C. Altieri, Lucia R. Languino   +10 more
doaj   +1 more source

Canalization of the Vestibular Plate in the Absence of Urethral Fusion Characterizes Development of the Human Clitoris: The Single Zipper Hypothesis. [PDF]

, 2016
PurposeWe characterized the early gestation development of the female external genitalia using optical projection tomography to visualize anatomical structures at high resolution.Materials and methodsFirst and early second trimester human female fetal ...
Baskin, Laurence, Botta, Sisir, Cao, Mei, Cunha, Gerald, Li, Yi, Overland, Maya, Shen, Joel, Sinclair, Adriane, Yue, Xuan   +8 more
core   +2 more sources

Androgen receptor phosphorylation status at serine 578 predicts poor outcome in prostate cancer patients [PDF]

, 2016
Purpose: Prostate cancer growth is dependent upon androgen receptor (AR) activation, regulated via phosphorylation. Protein kinase C (PKC) is one kinase that can mediate AR phosphorylation. This study aimed to establish if AR phosphorylation by PKC is of
Edwards, J., Heng, J.S., Horgan, P.G., Leung, H.Y., Patek, S.C., Taylor, B., Underwood, M.A., Willder, J.M.   +7 more
core   +1 more source

Androgen receptor epigenetics.

Translational andrology and urology, 2013
The androgen receptor (AR) is a transcription factor that drives the differentiation of prostate epithelium by regulating the expression of several hundred genes. Conversely, AR also plays a central role in prostate cancer (PCa) development, and it continues to be active in tumors that relapse after castration (castration-resistant prostate cancer ...
Cai, Changmeng, Yuan, Xin, Balk, Steven P.   +2 more
openaire   +2 more sources

Second-Generation Antiandrogens: From Discovery to Standard of Care in Castration Resistant Prostate Cancer

Frontiers in Oncology, 2019
Prostate cancer is the most commonly diagnosed cancer affecting men in the United States. The prostate is a hormone-dependent gland in which androgen hormones testosterone and dihydrotestosterone bind to and activate the androgen receptor, initiating ...
Meghan A. Rice, Sanjay V. Malhotra, Sanjay V. Malhotra, Tanya Stoyanova   +3 more
doaj   +1 more source

EPI-001, A Compound Active against Castration-Resistant Prostate Cancer, Targets Transactivation Unit 5 of the Androgen Receptor [PDF]

, 2017
ACKNOWLEDGEMENTS We thank J. M. Valverde (IRB) as well as the NMR facilities of the University of Barcelona (CCiT UB) and the Instituto de Química Física Rocasolano (IQFR, CSIC) for their assistance in, respectively, protein production and NMR. This work
Bertoncini, Carlos W., Buzon, Victor, De La Fuente, Alex, Escobedo, Albert, Estebanez-Perpina, Eva, Fenwick, R. Bryn, Garcia, Jesus, McEwan, Iain J., Moll, Eva De, Phang, Christopher T.W., Riera, Antoni, Salvatella, Xavier, Szulc, Elzbieta   +12 more
core   +2 more sources