Results 41 to 50 of about 140,287 (313)

Severe forms of partial androgen insensitivity syndrome due to p.L830F novel mutation in androgen receptor gene in a Brazilian family

BMC Research Notes, 2011
Background The androgen insensitivity syndrome may cause developmental failure of normal male external genitalia in individuals with 46,XY karyotype.
Guerra-Junior Gil, de Calais Flávia L, Soardi Fernanda C, Maciel-Guerra Andréa T, Petroli Reginaldo J, de Mello Maricilda   +5 more
doaj   +1 more source

Research Progress of Androgen/Androgen Receptor Signaling Pathway in Hepatocellular Carcinoma

Zhongliu Fangzhi Yanjiu, 2023
Hepatocellular carcinoma (HCC) is a kind of primary liver cancer with a high mortality rate. In China, the incidence ratio in males to females with HCC is 2:1–5:1.
WANG Ruihua, CAI Shiliang, LIU Donghong, CHEN Hongsen, CAO Guangwen   +4 more
doaj   +1 more source

Androgens and androgen receptor signaling in prostate tumorigenesis [PDF]

Journal of Molecular Endocrinology, 2014
Androgens and androgen receptor (AR) signaling are necessary for prostate development and homeostasis. AR signaling also drives the growth of nearly all prostate cancer cells. The role of androgens and AR signaling has been well characterized in metastatic prostate cancer, where it has been shown that prostate cancer cells are exquisitely adept at ...
Ye, Zhou, Eric C, Bolton, Jeremy O, Jones   +2 more
openaire   +2 more sources

Androgen-induced rhox homeobox genes modulate the expression of AR-regulated genes [PDF]

, 2010
Rhox5, the founding member of the reproductive homeobox on the X chromosome (Rhox) gene cluster, encodes a homeodomain-containing transcription factor that is selectively expressed in Sertoli cells, where it promotes the survival of male germ cells ...
Hu, Z.Y., Hu, Z., Verhoeven, G., De Gendt, K., Dandekar, D., Wilkinson, M.F., Wilkinson, M., O'Shaughnessy, P.J.   +7 more
core   +1 more source

Androgen receptor expression in hypospadias

Journal of Indian Association of Pediatric Surgeons, 2020
The exact mechanism behind the development of hypospadias is unclear. Research studies on androgen receptor (AR) expression are controversial with results stating all possible outcomes - AR elevated, similar, or reduced when compared to normal.The aim is to study the AR expression and hormone levels in hypospadias patients and compare them with ...
Dhanvanth Rajesh Balaji, Goutham Reddy, Ramesh Babu, Balamourougane Paramaswamy, Madhu Ramasundaram, Prakash Agarwal, Leena Dennis Joseph, Lawrence D'Cruze, Sandhya Sundaram   +8 more
openaire   +3 more sources

Therapeutic potential of TRPM8 antagonists in prostate cancer

Scientific Reports, 2021
Transient receptor potential melastatin-8 (TRPM8) represents an emerging target in prostate cancer, although its mechanism of action remains unclear.
Marzia Di Donato, Carmine Ostacolo, Pia Giovannelli, Veronica Di Sarno, Isabel M. Gomez Monterrey, Pietro Campiglia, Antimo Migliaccio, Alessia Bertamino, Gabriella Castoria   +8 more
doaj   +1 more source

The epigenetic function of androgen receptor in prostate cancer progression

Frontiers in Cell and Developmental Biology, 2023
Androgen and androgen deprivation (castration) therapies, including androgen receptor antagonists, are clinically used to treat patients with prostate cancer.
Takahiro Sawada, Takahiro Sawada, Yoshiaki Kanemoto, Yoshiaki Kanemoto, Tomohiro Kurokawa, Tomohiro Kurokawa, Tomohiro Kurokawa, Shigeaki Kato, Shigeaki Kato, Shigeaki Kato   +9 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Androgen receptors as a prognostic and predictive factor in breast cancer.

Folia Histochemica et Cytobiologica, 2008
Many theoretical and experimental models indicate that androgen receptors can play an important role as prognostic factors in breast cancer. The aim of this study was to evaluate the correlations between the presence of androgen receptors on cancer cells
Jerzy Rudnicki, Piotr Zukrowski, Zygmunt Grzebieniak, Michał Jeleń, Anil K Agrawal, Ewa Nienartowicz   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source