Results 91 to 100 of about 30,131 (248)
CA: A Cancer Journal for Clinicians, Volume 76, Issue 1, January/February 2026.ABSTRACT The hormone receptor (HR)‐positive/human epidermal growth factor receptor 2 (HER2)‐negative breast cancer subtype accounts for most early and metastatic breast cancer (MBC) cases. HR‐positive/HER2‐negative MBC is characterized by a relatively prolonged, although variable, disease course and substantial intertumoral and intratumoral ...
Akshara Singareeka Raghavendra +5 more
wiley +1 more source
Evaluating the Term ‘Disorders of Sex Development’: A Multidisciplinary Debate
Social Medicine, 2018 In 2014, almost 10 years after the 2005 International Consensus Conference on Intersex in Chicago, one of the conference co-organisers, under the auspices of a number of international paediatric endocrinology societies, launched the Global DSD Update to ...
Natalie Delimata +5 more
doaj
Embryonal carcinoma in androgen insensitivity syndrome
Indian Journal of Medical and Paediatric Oncology, 2011 Embryonal cell carcinoma is a rare clinical entity. We report a case of a 20-year-old patient who presented with lump lower abdomen for last two months with primary amenorrhea and poorly developed secondary sexual characteristics.
Debabrata Barmon +3 more
doaj +1 more source
Telangana Journal of Psychiatry, 2023 Complete androgen insensitivity syndrome (CAIS) is a rare condition resulting due to the inability of the cell to respond to the masculine hormone (androgen). Often, CAIS patients identify themselves as female and may experience significant psychological
Mysore Narasimha Vranda +7 more
doaj +1 more source
Androgen and estrogen receptor expression in the developing human penis and clitoris. [PDF]
, 2020 To better understand how the human fetal penis and clitoris grows and remodels, we undertook an investigation to define active areas of cellular proliferation and programmed cell death spatially and temporally during development of human fetal external ...
Baskin, Laurence +6 more
core
Androgen receptor polymorphisms and testicular cancer risk [PDF]
, 2015 Testicular cancer (TC) is currently the most common malignant solid tumour in Caucasian males aged 15-39 years. Epidemiological evidence suggests that its onset may be due to an imbalance in the action of steroidal sex hormones and their receptors.
CARLINI, TANIA +9 more
core +1 more source
Engineering the Link: From Genome Interaction Maps to Functional Insight
Advanced Biology, Volume 9, Issue 12, December 2025.Advances in chromosome conformation capture have revealed the genome's 3D organization, yet its causal impact on gene regulation remains elusive. This review highlights emerging genome‐engineering tools ‐ zinc fingers, TALEs, and CRISPR‐Cas9 ‐ that enable targeted manipulation of chromatin loops to dissect structure–function relationships. It discusses
Frido Petersen +5 more
wiley +1 more source
A novel de novo androgen receptor nonsense mutation in a sex-reversed 46,XY infant
Human Genome Variation, 2021 An infant with 46,XY karyotype, and unambiguous female phenotype was found to have testes in the inguinal regions. Capillary sequencing of the androgen receptor (AR) gene identified a hemizygous de novo mutation (NM_000044.6:c.1621G > T) in exon 2 ...
Kok-Siong Poon +2 more
doaj +1 more source
Meta-analysis of Androgen Insensitivity in Preoperative Hormone Therapy in Hypospadias. [PDF]
, 2015 OBJECTIVE: To define androgen insensitivity prevalence in hypospadias patients treated with preoperative hormone therapy. MATERIALS AND METHODS: We searched databases that were published in English and Chinese up to September 10, 2014 for our studies ...
Ahmed +36 more
core +1 more source
Reproductive Biology and Endocrinology, 2020 Background Abnormal androgen receptor (AR) genes can cause androgen insensitivity syndrome (AIS), and AIS can be classified into complete androgen insensitivity syndrome (CAIS), partial androgen insensitivity syndrome (PAIS) and mild AIS. We investigated
Qingxu Liu, Xiaoqin Yin, Pin Li
semanticscholar +1 more source