Results 111 to 120 of about 30,131 (248)

Disorders of sex development (DSD): an overview of recent scientific advances [PDF]

, 2014
Developments in biotechnology have radically altered clinical and research themes in the small field of disorders of sex development, as in other rare medical conditions. In the age of genetics, an increasing number of DSDs have been identified. Aided by
Conway, GS
core  

Structural analysis of the impact of a novel androgen receptor gene mutation in two adult patients with mild androgen insensitivity syndrome

Andrologia, 2020
Androgen receptor gene (AR) mutations are responsible for androgen insensitivity syndrome (AIS) presenting with a clinical phenotype that ranges from gynaecomastia and/ or infertility in mild AIS (MAIS) to complete testicular feminisation in complete AIS.
M. Hage, D. Drui, B. Francou, S. Mercier, A. Guiochon‐Mantel, J. Belaisch‐ALLART, Y. Péréon, L. Cazabat, P. de Mazancourt, M. Raffin-Sanson   +9 more
semanticscholar   +1 more source

Extracellular Vesicles Released From Prostate Cancer Cells Confer Pro‐Tumor Properties to Adipocytes by Stimulating Lipolysis

BioFactors, Volume 51, Issue 6, November/December 2025.
Extracellular vesicles (EVs) from prostate cancer (PCa) cells induce the release of fatty acids (FFAs) from adipocytes, which in turn sustain tumor cell proliferation and migration via Akt activation. ABSTRACT There is consistent evidence of an association between obesity and the risk of prostate cancer (PCa). A crosstalk between PCa and adipocytes has
Gaia Giannitti, Kinga Kamińska, Sara Marchesi, Riccardo Garavaglia, Ivan Preosto, Małgorzata Grzesiak, Fabrizio Fontana   +6 more
wiley   +1 more source

Complete androgen insensitivity syndrome: Dilemmas for further management after gonadectomy

Journal of Human Reproductive Sciences, 2019
Complete androgen insensitivity syndrome is a rare condition, wherein a genetic male is phenotypically female and is raised as a female. Treatement requires timely gonadectomy, need for long term hormonal replaceent therapy, psycological and genetic ...
Pratibha Singh, Meenakshi Gothwal, Garima Yadav, Kuldeep Singh   +3 more
doaj   +1 more source

Variable loss of functional activities of androgen receptor mutants in patients with androgen insensitivity syndrome [PDF]

, 2013
Androgen receptor (AR) mutations in androgen insensitivity syndrome (AIS) are associated with a variety of clinical phenotypes. The aim of the present study was to compare the molecular properties and potential pathogenic nature of 8 novel and 3 ...
Akker, E.L.T. (Erica) van den, Bisschop, P.H. (Peter), Bosch, R. (Rolien), Brinkmann, A.O. (Albert), Brüggenwirth, H.T. (Hennie), Bunch, T. (Trevor), Bunck, M.C.M., Cools, M.B.C.M. (Martine), Drop, S.L.S. (Stenvert), Elfferich, P.C., Faradz, S.M.H. (Sultana), Houtsmuller, A.B. (Adriaan), Hughes, I.A. (Ieuan), Lusher, S.J. (Scott), Oostdijk, W. (Wilma), Royen, M.E. (Martin), Trapman, J. (Jan), Wijngaart, D.J. (Dennis) van de   +17 more
core   +2 more sources

Elucidating the Anticancer Mechanisms of Tetrahydroxycurcumin: A Comprehensive Review of Preclinical Studies

Food Science &Nutrition, Volume 13, Issue 11, November 2025.
Tetrahydroxycurcumin is an attractive multifunctional compound in cancer‐driven therapeutics. Its anticancer potential in modulating a wide range of oncogenic signaling networks, combined with its dual properties as an antioxidant and anti‐inflammatory agent, highlights its potential to become a transformative anticancer drug.
Muhammad Shahbaz, Ushna Momal, Hagar M. Mohamed, Asfa Perween, Hammad Naeem, Muhammad Imran, Muzzamal Hussain, Gamal A. Mohamed, Sabrin R. M. Ibrahim, Tadesse Fenta Yehuala, Suliman A. Alsagaby, Waleed Al Abdulmonem, Mohamed A. Abdelgawad, Ehab M. Mostafa, Samy Selim   +14 more
wiley   +1 more source

GENDER ASSIGNMENT IN COMPLETE ANDROGEN INSENSITIVITY SYNDROME. WHO SHOULD BE THE DECISION MAKER

Pakistan Armed Forces Medical Journal, 2020
Androgen insensitivity syndrome (AIS) is a condition in which the target cells are unable to respond to androgenic hormones. This inability can be complete or partial.
Naveed Ahmed, Iftikhar Ahmed, Safdar Awan, Omair Arshad Dar, Shehla Kanwal, C. Aqeel Safdar, Mudasir Saleem   +6 more
doaj   +2 more sources

A Recurrent Germline Mutation in the 5'UTR of the Androgen Receptor Causes Complete Androgen Insensitivity by Activating Aberrant uORF Translation. [PDF]

PLoS ONE, 2016
A subset of patients with monogenic disorders lacks disease causing mutations in the protein coding region of the corresponding gene. Here we describe a recurrent germline mutation found in two unrelated patients with complete androgen insensitivity ...
Nadine C Hornig, Carine de Beaufort, Friederike Denzer, Martine Cools, Martin Wabitsch, Martin Ukat, Alexandra E Kulle, Hans-Udo Schweikert, Ralf Werner, Olaf Hiort, Laura Audi, Reiner Siebert, Ole Ammerpohl, Paul-Martin Holterhus   +13 more
doaj   +1 more source

Androgen Receptor Gene Variants in New Cases of Equine Androgen Insensitivity Syndrome

Genes, 2020
In the domestic horse; failure of normal masculinization and virilization due to deficiency of androgenic action leads to a specific disorder of sexual development known as equine androgen insensitivity syndrome (AIS).
D. Villagomez, Eastman G Welsford, W. King, T. Révay   +3 more
semanticscholar   +1 more source

Elevating and empowering reproductive futures: Pediatric and adolescent gynecology's specialized care across the globe

International Journal of Gynecology &Obstetrics, Volume 171, Issue 2, Page 528-537, November 2025.
Abstract Pediatric and adolescent gynecology (PAG) is an expanding subspecialty of obstetrics and gynecology that addresses the reproductive health needs of girls and young women worldwide. In regions with limited subspecialist healthcare providers, general obstetricians, gynecologists, and nurse‐midwives, frontline healthcare providers provide ...
Nichole A. Tyson, Méabh Ní Bhuinneáin, Hema Divakar, Lauren Mauger, Judith Simms Cendan, Marisa Labovsky, FIGO Committee on Adolescent and Youth Health   +6 more
wiley   +1 more source