Results 51 to 60 of about 959 (147)

Engineering Extracellular Vesicles for Anti‐Aging Therapy: Mechanisms, Applications, and Perspectives

Aging Cell, Volume 25, Issue 7, July 2026.
This review systematically elucidates the multifactorial anti‐aging mechanisms of extracellular vesicles (EVs). By bridging fundamental biology with advanced bioengineering, scalable manufacturing, and clinical translation, it establishes a comprehensive framework for developing next‐generation EVs‐based precision nanotherapeutics to combat systemic ...
Xian Huang, Qiujie Li, Guofang Tao, Xulin Gan, Jiangjie Lu, Sergei Krasny, Liyun Shi   +6 more
wiley   +1 more source

Exploring the Efficacy and Safety of Topical Phenytoin in Androgenetic Alopecia: A Clinical Investigation

Journal of Cosmetic Dermatology, Volume 25, Issue 7, July 2026.
ABSTRACT Background Phenytoin, a widely used antiepileptic drug, is known for its proliferative effects on fibroblasts and keratinocytes, as well as its stimulatory influence on angiogenesis. One of its notable side effects is hirsutism, which suggests a potential role in hair growth promotion.
Sina Maskoukian, Atefeh Naeimifar, Aniseh Samadi, Hamid Akbari Javar, Afsaneh Sadeghzadeh Bazargan, Saman Ahmad Nasrollahi, Alireza Firooz   +6 more
wiley   +1 more source

Zebrafish as an Anti‐Isogenic Vertebrate Model and What It Reveals About Genetic Background and Reproducibility

BioEssays, Volume 48, Issue 6, June 2026.
Zebrafish illustrates how polygenic sex determination, maternal germline bottlenecks, and a structurally restless genome jointly destabilize deep homozygosity. These interlocking constraints make fully isogenic zebrafish lines effectively unattainable, turning this model into a natural “stress test” for assumptions about genetic background and ...
Álvaro J. Arana, Laura Sánchez
wiley   +1 more source

Two‐Year Follow‐Up of Ectodermal Dysplasia‐Syndactyly Syndrome 1 in a Palestinian Child Successfully Treated With Topical Minoxidil and Tretinoin: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
Clinical timeline of the reported EDSS1 case, illustrating disease onset, diagnostic milestones, treatment initiation, treatment modifications, and longitudinal response to combined topical minoxidil and tretinoin therapy from infancy through the last follow‐up.
Bana O. Aburajab, Hamza M. A. Ghaith, Nada Ishti, Muawia O. Aburajab   +3 more
wiley   +1 more source

A Theoretical Model for the Treatment of Androgenetic Alopecia Using the STEAP3 Protein, and the Genetic Challenges of Treating AGA

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Androgenetic alopecia (AGA) is a prevalent condition. The treatment methods currently available for this condition have limited potential (minoxidil) and side effects with long‐term therapy that affect the physiology of the male population (5α‐reductase inhibitors).
Ignacy Klemens Młodzianowski, Małgorzata Grochocka, Tadeusz Tadrowski, Marta Hałas‐Wiśniewska, Magdalena Izdebska   +4 more
wiley   +1 more source

Current Status of Haploidization in Cool-Season Grain Legume Crop Species

Agriculture
Doubled haploid technology is, so far, the fastest route to induce a true homozygous state in plants. True homozygous plants are particularly important for breeders, as they can facilitate hybrid breeding and are useful in fixing traits in a breeding ...
Wiktor Skrzypkowski, Agnieszka Kiełkowska   +1 more
doaj   +1 more source

Efficient Androgenic Embryo Induction and Plant Regeneration in Different Genotypes of Sweet Pepper via Anther Culture

Journal of Pure and Applied Microbiology, 2017
Creation of pure lines is one of the basic requirements in plant breeding. Doubled haploid (DH) lines are completely homozygous lines and anther culture is an efficient method for DH line production.
Ali Akbar Heidari, Mehran E. Shariatpanahi, Amir Mousavi, Sepideh Kalatejari   +3 more
doaj   +1 more source

Systemic Absorption and Pharmacokinetics of Five Novel Topical Dermatologic Agents: A Review

JEADV Clinical Practice, Volume 5, Issue 2, Page 385-393, June 2026.
ABSTRACT In recent years, innovative topical medications with novel mechanisms of action have emerged to treat common dermatologic conditions such as acne, atopic dermatitis, vitiligo, and actinic keratoses. These molecularly targeted therapies offer improved safety and tolerability compared to traditional options like corticosteroids.
Mary Dyson, Kara Hurley, Hannah Chaudhury, Lara Shehadeh, Cameron West   +4 more
wiley   +1 more source

Analysis of Human Uniparental Embryonic Stem Cells Reveals New Putative Imprinted Loci

Cell Proliferation, Volume 59, Issue 6, June 2026.
To identify novel imprinted genes, parthenogenetic, androgenetic and biparental human embryonic stem cells and their differentiated neural progenitors were analysed by methylome and transcriptome profiling. This approach uncovered 12 putative novel imprinted genes, including a clustered region on chromosome 19, expanding the current catalogue of ...
Shay Kinreich, Nissim Benvenisty
wiley   +1 more source

From Hair to Healing: Follicular Unit Transplantation for Chronic Ulcer Management—A Case Series

International Wound Journal, Volume 23, Issue 6, June 2026.
ABSTRACT Scalp follicular unit (FU) transplantation is a highly effective yet underutilised minimally invasive technique for promoting healing in chronic and recalcitrant cutaneous wounds. In this case series, five patients with long‐standing nonhealing leg ulcers of mixed etiologies were treated exclusively with single FU grafts harvested from the ...
Francisco Jimenez, Aditya K. Gupta, Jerry Cooley, Adriana Peña‐Escobar, Mesbah Talukder   +4 more
wiley   +1 more source