Results 91 to 100 of about 238,876 (343)
Cancer Communications, EarlyView.Abstract Background Third‐generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) show initial efficacy in EGFR‐mutated lung cancer, but residual disease persists. This study aimed to investigate cluster of differentiation 24 (CD24) as a translational immunotherapeutic target for enhancing third‐generation EGFR‐TKI efficacy.
Jiaqi Liang +16 more
wiley +1 more source
Chemistry &Biodiversity, EarlyView.ABSTRACT Epimedium (EP) is a traditional Chinese medicine that has been used to treat osteoporosis for several years, but its mechanism of action is unclear. We used ultrahigh‐performance liquid chromatography coupled with triple–quadrupole mass spectrometry (UPLC–QQQ–MS/MS) to detect the components of raw and processed EP samples.
Jinling Liang +8 more
wiley +1 more source
Biocompatible Chemistry: A Plug‐and‐Play Toolbox for Chemical Biology Research
ChemBioChem, EarlyView.The “plug‐and‐play” nature of biocompatible chemistry makes it a powerful toolbox for investigating complicated biological systems and producing drug leads for clinical usages. This review summarizes the commonly used biocompatible reactions and the recent advances of their representative applications in chemical biology research, thus highlighting the
Adam R. Lovato, Zeng Lin, Qingfei Zheng
wiley +1 more source
Targeting Cryptochromes in Chronic Diseases
Cell Biology International, EarlyView.ABSTRACT The circadian clock generates 24‐h molecular rhythms through transcription–translation negative feedback loops (TTFLs) and regulates daily physiological processes such as sleep–wake cycles, body temperature, hormone secretion, metabolism, and immune function.
Takuro Toda, Tsuyoshi Hirota
wiley +1 more source
Chemistry – A European Journal, EarlyView.A facile synthesis of unsymmetrical 1,1’‐disubstituted ferrocene derivatives based on the desymmetrization of 1,1’‐diborylferrocene was developed. Suzuki‐Miyaura cross‐coupling (SMCC) reaction of 1,1’‐diborylferrocene afforded mono‐substituted products without significant loss of the second boryl group, and the subsequent second SMCC reaction afforded ...
Kotaro Ochiai +2 more
wiley +1 more source
Molecular Docking and Target‐Specific Binding Profiles of Benzosuberane‐Based Compounds
ChemMedChem, EarlyView.Benzosuberane represents a promising scaffold in medicinal chemistry. Several benzosuberane‐based derivatives are described in this review as anticancer agents, including antivascular agents, DNA‐intercalators, receptor modulators and kinase inhibitors.
Michail A. Saragatsis +3 more
wiley +1 more source
Acta Scientiarum: Biological Sciences, 2019 The steroid hormones are lipids in nature, which play crucial roles in several metabolic and behavioral pathways in mammals. Drug therapy uses sterol hormones for treating some disturbances linked with its deficiency; however, the illicit use of these ...
Luís Flávio Souza de Oliveira +3 more
doaj +1 more source
11-Oxygenated androgens in health and disease
Nature Reviews Endocrinology, 2020 Adina F. Turcu +3 more
semanticscholar +1 more source
Detection of a Single Microdose of Testosterone and Recombinant EPO in Healthy Volunteers
Drug Testing and Analysis, EarlyView.Exogenous T was detected with IRMS regardless of T/E elevation—high serum T indicative for IRMS. rhEPO was detected in urine for 72 h in ITP and CP, and Tasso showed less sensitivity than previous DBS devices tested. ABSTRACT Doping with testosterone (T) and erythropoietin (EPO) in low doses (micro‐doping) is a challenge to detect.
Carmel Heiland +5 more
wiley +1 more source