Results 81 to 90 of about 141,437 (356)

Dual‐Target Nectin‐4/FAP Heterobivalent Probe 68Ga/177Lu‐FZ‐NF‐1 for Triple‐Negative Breast Cancer: Preclinical Theranostic Evaluation and First‐in‐Human Translation

Advanced Science, EarlyView.
A novel hetero‐bivalent agent, 68Ga/177Lu‐FZ‐NF‐1, concurrently targets Nectin‐4 and FAP in triple‐negative breast cancer. It yields significant preclinical tumor regression and clinically identifies additional metastatic lesions missed by 18F‐FDG PET, demonstrating promising theranostic potential for personalized management.
Ye Li, Li Sun, Xiaoyu Pan, Shuyi Lin, Dongliang Wang, Jianping Zhang, Fengshuang Qiu, Bin Zhu, Lingzhou Zhao, Fengsheng Zhang, Liyan Bai, Bingxin Gu, Xiaoping Xu, Shaoli Song   +13 more
wiley   +1 more source

Androgens

, 2007
The male gonads (more precisely, the interstitial cells or the cells of Leydig in the testes) and, to a lesser extent, the adrenal cortex (secretes androstenedione and dehydroepiandrosterone that are converted in the periphery to testosterone or estrogen)
Kay Marshall, Marshall, K.; id_orcid
core   +1 more source

Immunological, vascular and metabolic actions of androgens [PDF]

, 2018
Men have higher prevalence of cardiovascular disease (CVD) but lower risk of autoimmune disorders than women. The actions of sex steroids may be involved in the sexual dimorphism of these diseases.
Lantero Rodriguez, Marta, Varun N. Kapoor, Bo T. Porse, Maria E. Johansson, Turley, S. J., Alessandro Camponeschi, Nissbrandt, Hans,, Johansson, Inger,, Lianoglou, S, Johansson ME, Buechler, M. B., Steve Lianoglou, Mårtensson IL, Fogelstrand, Per,, Hans Carlsten, Lianoglou, S., Kapoor VN, Lianoglou S, Rolink AG, Kapoor, V. N., Nissbrandt H, Stubelius, Alexandra,, Buechler, MB, Fagman JB, Amanda Duhlin, Stubelius, A, Mikael C. I. Karlsson, Tripathi, P., Lantero Rodriguez, Marta,, Johan B. Fagman, Karlsson MCI, Anna S. Wilhelmson, Johansson, I, Camponeschi A, Prabhanshu Tripathi, Karlsson, M. C. I., Porse, B. T., Inger Johansson, Porse BT, Mårtensson, Inga-Lill,, Fogelstrand P, Per Fogelstrand, Åsa Tivesten, Wilhelmson AS, Fogelstrand, P, Lantero Rodriguez M, Buechler MB, Rodriguez, ML, Kapoor, VN, Antonius G. Rolink, Carlsten, Hans,, Fagman, JB, Stubelius A, Shannon J. Turley, Duhlin A, Marta Lantero Rodriguez, Tivesten, Åsa,, Camponeschi, Alessandro,, Duhlin, A., Tripathi P, Inga-Lill Mårtensson, Wilhelmson, AS, Tivesten Å, Alexandra Stubelius, Matthew B. Buechler, Hans Nissbrandt, Johansson, Maria E,, Johansson, ME, Fagman, Johan Bourghardt,, Carlsten H, Rolink, A. G., Wilhelmson, Anna S K,, Johansson I, Turley SJ   +73 more
core   +1 more source

SAV1 in Cooperation With FKBP52 Participates in Implantation

Advanced Science, EarlyView.
The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.
Yuhan Shao, Yafang Lu, Zhaoyu Jia, Junxiang Ren, Ziyi Ge, Xinyu Liu, Hui Zhao, Zi‐Jiang Chen, Junhao Yan, Wei Wang, Jia Yuan   +10 more
wiley   +1 more source

The role of androgens on experimental pain sensitivity: a systemic review and meta-analysis

PAIN Reports
. Animal studies have shown androgens, especially testosterone, may have an analgesic effect on nociceptive behavior. However, it is unclear if this effect is present in humans.
Elizabeth Wu-Chen, Gourav Banerjee, Elise Requadt, Benjamin Hunter, Thomas J. Baranski, Whitney Trotter Ross, Hadas Nahman-Averbuch   +6 more
doaj   +1 more source

The association between serum testosterone and insulin resistance: a longitudinal study

Endocrine Connections, 2018
The objective of this study was to investigate whether there is a bidirectional association between testosterone concentrations and insulin resistance, in a prospective population study. A random population sample of 1400 men, aged 30–74, was examined in
Kristin Ottarsdottir, Anna G Nilsson, Margareta Hellgren, Ulf Lindblad, Bledar Daka   +4 more
doaj   +1 more source

Androgens and the skeleton

, 2005
Loss of estrogens or androgens causes bone loss by increasing the rate of bone remodeling, and also causes an imbalance between resorption and formation by prolonging the lifespan of osteoclasts and shortening the lifespan of osteoblasts.
Bouillon, Roger, Ohlsson, Claes,, Vandenput, Liesbeth,, Vanderschueren, Dirk, Lagerquist, Marie,, Movérare-Skrtic, Sofia,, Boonen, Steven   +6 more
core  

Dual Compartmentalization of GSTA4 Suppresses Ferroptosis to Drive Antiandrogen Resistance in Prostate Cancer

Advanced Science, EarlyView.
The schematic diagram depicts a compartmentalized anti‐ferroptotic defense mechanism mediated by GSTA4. GSTA4 is upregulated and localizes to the cytoplasm in ENZR cells, where it detoxifies 4‐HNE via a non‐canonical GSH‐dependent pathway. Under oxidative stress, GSTA4 translocates to mitochondria, interacts with PGAM5, and blocks Drp1 Ser637 ...
Yong Luo, Wei Zhuang, Zean Li, Yiming Lai, Yongyi Ou, Dongquan Li, Shanhe Huang, Tianlong Luo, Jintao Hu, Bingliang Chen, Jianhan Fu, Tao Zhuo, Hankun Jiang, Yin Lu, Hai Huang, Kewei Xu, Shengmeng Peng, Qing Yuan   +17 more
wiley   +1 more source

Cavernous haemangioma mimicking as clitoral hypertrophy

African Journal of Paediatric Surgery, 2014
Haemangioma is the most common benign neoplasm of infantile age. It is most commonly located in head and neck region, trunk and extremities but very rarely it can be located at clitoris. However, it is very important to differentiate clitoral haemangioma
Sajid Nayyar, Naeem Liaqat, Nayyar Sultan, Sajid Hameed Dar   +3 more
doaj   +1 more source

Degrading GPX4 via Biomimetic Nanoparticle‐Mediated In Situ Synthesis of Deep‐Learning‐Designed Binder‐Degron Chimeras for Prostate Cancer Therapy

Advanced Science, EarlyView.
A deep‐learning‐designed binder is fused to a combinatorial degron to create a binder‐degron chimera (bdC) that recruits the CUL2‐RING ubiquitin ligase complex. Encapsulation in a prostate‐cancer‐targeted, CD47‐camouflaged nanocarrier enables tumor‐specific in situ bdC expression, triggering GPX4 degradation and ferroptosis, thereby establishing a ...
Si‐Han Zhang, Ye An, Na Zeng, Mei‐Cheng Liu, Jian‐Xuan Sun, Xi Gong, Jin‐Zhou Xu, Shao‐Gang Wang, Qi‐Dong Xia   +8 more
wiley   +1 more source