Results 91 to 100 of about 141,437 (356)

High maternal androstenedione levels during pregnancy in a small precocial mammal with female genital masculinisation [PDF]

-Masculinisation of female genitalia is an intriguing phenomenon amongst some mammalian species and its endocrinological basis as well as its adaptive value is still heavily debated. We recently reported female genital masculinisation in Cavia magna. The
Cornelia Kraus, Kristina A. Pfannkuche, Ton G. G. Groothuis, Fritz Trillmich   +3 more
core  

What Role do Androgens Play in Endometrial Cancer?

, 2023
The role of estrogens and progesterone in the development and progression of endometrial cancer is well-established, but there are very little data about the role of androgens.
Jure Knez, Petra Maček, Nikolaus Molinari, Monika Sobočan, Sobočan, Monika, Molinari, Nikolaus, Knez, Jure, Maček, Petra   +7 more
core   +1 more source

DUET‐seq: An Open‐Source Droplet Platform for High‐Fidelity Joint Chromatin and Transcriptome Profiling Reveals Temporal Regulatory Decoupling in Single Cells

Advanced Science, EarlyView.
DUET‐seq is an open‐source droplet platform that jointly profiles chromatin accessibility and gene expression from the same nucleus. Dissolvable dual‐linker hydrogel beads and a one‐step intra‐droplet RT‐PCR co‐index both modalities in under 12 h at roughly $0.04 per cell.
Dong Cheng, Zijun Meng, Lan Wei, Pingjing Yang, Fanfan Zhang, Zhiyi Luo, Ting Lai, Chunli Li, Mengyao Zhao, Mengqin Xu, Jiaqi Wang, Linjun Li, Huarong Chen, Jin Li, Ailong Huang, Youquan Bu, Liuyang Zhao   +16 more
wiley   +1 more source

Insulin sensitivity, androgens and isotretinoin therapy in women with severe acne

, 2014
Background: Androgens appear to play a role in the development of acne, and presence of acne is a potential marker of hyperandrogenism. Objective: The authors evaluated androgens and insulin sensitivity markers before and after treatment with ...
AKSOY, Duygu Yazgan, CETINOZMAN, Fatma, YILDIZ, BUĞRA, Elcin, GONCA   +3 more
core   +1 more source

Direct action through the Sertoli cells is essential for androgen stimulation of spermatogenesis [PDF]

, 2010
Androgens act to stimulate spermatogenesis through androgen receptors (AR) on the Sertoli cells and peritubular myoid cells (PTM). Specific ablation of the AR in either cell type will cause a severe disruption of spermatogenesis.
Abel, M.H., Verhoeven, G., De Gendt, K., Monteiro, A., O'Shaughnessy, P.J.   +4 more
core   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Resurrecting FUS: Adrenal Androgens as an Ultimate Cause of Hematuria, Periuria, Pollakuria, Stranguria, Urolithiasis and Obstruction in Neutered Cats

Frontiers in Veterinary Science, 2018
Although many authors have doubted that “feline urological syndrome” (FUS) describes a real pathogenetic entity, because it subsumes such a large variety of signs, Sumner's recent finding that urethral obstruction occurs most frequently in springtime ...
Brandon P. Reines, Brandon P. Reines, Robert A. Wagner   +2 more
doaj   +1 more source

Single‐Nucleus Transcriptomic Atlas of Human Vellus Hair Pilosebaceous Units Reveals Age‐Associated Remodeling

Advanced Science, EarlyView.
Human vellus pilosebaceous units (PSUs) remain uncharted. This single‐nucleus atlas reveals coordinated remodeling of the aging PSU niche: reduced bulge stem cell representation with altered regenerative programs, increased representation of a stress‐responsive channel+ epithelial state, enhanced androgen‐responsive sebaceous programs, reduced ...
Ya'nan Li, Zhuoqiong Qiu, Xiaoyu Pan, Geyang Xu, Shanshan Peng, Ronghui Zhu, Qiuyang Luo, Xiaokai Fang, Xu Yao, Wei Li   +9 more
wiley   +1 more source

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

Advanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian, Guicheng Zhao, Xiang Wang, Xinyao Tang, Gan Shen, Tiechao Ruan, Chuan Jiang, Shikun Zhao, Jincheng Zhang, Xinyue Cui, Liangchai Zhuo, Jun Ma, Yihong Yang, Tingting Lin, Ying Shen   +14 more
wiley   +1 more source

The Point of View of Pathophysiologist-Endocrinologist on the Problem of Age-Related Androgen Deficiency in Men (LOH-Syndrome)

Mìžnarodnij Endokrinologìčnij Žurnal, 2014
The paper presents a pathophysiological analysis of age-related androgen deficiency syndrome in men (LOH-syndrome) with special reference to current knowledge of molecular mechanisms of testosterone effects and androgen regulation of the structure and ...
A.G. Reznikov
doaj   +1 more source