Results 1 to 10 of about 3,649,731 (302)

Considerations on the Obstacles That Lead to Slow Recruitment in a Pain Management Clinical Trial: Experiences from the Belgian PELICAN (PrEgabalin Lidocaine Capsaicin Neuropathic Pain) Pragmatic Study

Pain Research and Management, 2023
Background. A qualitative evaluation study of the prematurely terminated PrEgabalin Lidocaine Capsaicin Neuropathic Pain (PELICAN) study was performed.
Guy H. Hans, Dima Almeshal, Lotte Vanlommel, Ella Roelant, Iris Verhaegen, Elke Smits, Koen Van Boxem, Robert Fontaine, The PELICAN Investigators Team   +8 more
doaj   +1 more source

Parents' perceived obstacles to pediatric clinical trial participation: Findings from the clinical trials transformation initiative. [PDF]

, 2018
Enrollment of children into pediatric clinical trials remains challenging. More effective strategies to improve recruitment of children into trials are needed.
Benjamin, Daniel K, Bloom, Diane, Bradley, John, Gamel, Breck, Greenberg, Rachel G, Hinton, Denise, Jafri, Hasan S, Nambiar, Sumathi, Roberts, Jamie, Smith, P Brian, Tiernan, Rosemary, Wheeler, Chris   +11 more
core   +5 more sources

Development and Validation of a Prediction Model for Venous Thrombus Embolism (VTE) in Patients With Colorectal Cancer

Technology in Cancer Research & Treatment, 2023
Cancer patients are at high risk of developing venous thromboembolism (VTE). The risk of VTE could be mitigated with the administration of prophylactic anticoagulants.
Wei-Juan Tan MS, Lu Chen MS, Sheng-Jie Yang MD, Bao-Ying Zhang MD, Ming-Li Sun MD, Yu-Bin Lin MS, Xing-He Wang MD, PhD   +6 more
doaj   +1 more source

Feasibility of simple exercise interventions for men with osteoporosis – A prospective randomized controlled pilot study

Bone Reports, 2021
Background: Aging is associated with progressive loss of musculoskeletal performance. Exercise interventions can improve physical function in the elderly but there is a paucity of comparative assessments in order to understand what specific goals can be ...
Franca Genest, Sarah Lindström, Sophia Scherer, Michael Schneider, Lothar Seefried   +4 more
doaj   +1 more source

Effect of a high‐fat and high‐calorie food on the pharmacokinetics of a novel, potent GABA analog HSK16149 in healthy subjects

Pharmacology Research & Perspectives, 2023
HSK16149 is a novel, potent gamma‐aminobutyric acid (GABA) analog for the treatment of neuropathic pain. The purpose of this study was to assess the effect of a high‐fat and high‐calorie meal on the pharmacokinetics of HSK16149 in healthy Chinese ...
Qingqing Wu, Huijuan Zhu, Rong Song, Mengqi Zhang, Fangqiong Li, Weifang Zeng, Wei Wang, Jingying Jia, Chen Yu, Yanmei Liu   +9 more
doaj   +1 more source

Co-expression and prognosis analyses of GLUT1–4 and RB1 in breast cancer

BMC Cancer, 2021
Background Current treatment methods for patients with triple-negative breast cancer (TNBC) are very limited, and the prognosis of TNBC is relatively poor.
Xiaodan Zhang, Xiaocong Pang, Zhuo Zhang, Qianxin Liu, Hanxu Zhang, Qian Xiang, Yimin Cui   +6 more
doaj   +1 more source

Differential impact of osteoporosis, sarcopenia and obesity on physical performance in aging men

Endocrine Connections, 2021
Purpose: Aging and concurrent constitutional changes as sarcopenia, osteoporosis and obesity are associated with progressive functional decline. Coincidence and mutual interference of this risk factors require further evaluation.
Franca Genest, Michael Schneider, Andreas Zehnder, Dominik Lieberoth-Leden, Lothar Seefried   +4 more
doaj   +1 more source

Application of Incident Command Structure to clinical trial management in the academic setting: principles and lessons learned [PDF]

, 2017
Background Clinical trial success depends on appropriate management, but practical guidance to trial organisation and planning is lacking. The Incident Command System (ICS) is the ‘gold standard’ management system developed for managing diverse ...
Michael, Mary J., Reynolds, Penny S., Spiess, Bruce D.   +2 more
core   +2 more sources

Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in acute lung injury to reduce pulmonary dysfunction (HARP-2) trial : study protocol for a randomized controlled trial [PDF]

, 2012
Acute lung injury (ALI) is a common devastating clinical syndrome characterized by life-threatening respiratory failure requiring mechanical ventilation and multiple organ failure.
A Mercat, AM Cheung, C Brun-Buisson, C Rossi, Cecilia M O’Kane, Christine McNally, Daniel F McAuley, DJ Kor, Excellence NIfHaC, F Gao Smith, Gavin D Perkins, GD Rubenfeld, GR Bernard, Grainne Crealey, Irish Critical Care Trials Group, John G Laffey, KF Schulz, LA Curtis, Lynn Murphy, M Shyamsundar, MA Matthay, Mark Cross, Michael Stevenson, MS Herridge, RG Brower, S Harvey, SE Erickson, T Craig, The ARDS Network investigators, The EuroQol Group, TR Craig, TW Felton   +31 more
core   +1 more source

Decision aids can support cancer clinical trials decisions: Results of a randomized trial [PDF]

, 2016
BACKGROUND. Cancer patients often do not make informed decisions regarding clinical trial participation. This study evaluated whether a web-based decision aid (DA) could support trial decisions compared with our cancer center’s website. METHODS.
Byrne, Margaret M, Kaphingst, Kimberly A, Kuzemchak, Marie D, Liu, Jingxia, Perkins, Hannah, Politi, Mary C   +5 more
core   +2 more sources