Results 41 to 50 of about 1,889,174 (167)

A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Highly Selective NaV1.8 Inhibitor JKN2306 in Healthy Chinese Subjects

Pharmacology Research & Perspectives
JKN2306 is a novel, highly selective Nav1.8 inhibitor under development for the treatment of acute pain. This first‐in‐human study aimed to evaluate its safety, tolerability, pharmacokinetics, and food effect (FE).
Ying Yang, Mai Han, Gang Cui, Dan Zhang, Wei Wu, Na Mi, Jiangli Jin, Shuxiao Zhang, Xin Zhang, Junjie Li, Chunyan Xiao, Jing Wang, Chaoyun Gou, Chong Su, Jintong Li   +14 more
doaj   +1 more source

Population Pharmacokinetic/Pharmacodynamic Modeling of Tacrolimus in Renal Transplant Recipients: Impact of CYP3A5 Genotype and Wuzhi Capsule Co-Medication

Drug Design, Development and Therapy
Qiulin Xiang,1 Yi Yang,1 Guoxing Li,1 Song Chen,1,2 Yingying Yang,1,3 Ling Liu,4 Xian Yu1 1Department of Phase I Clinical Trial Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Pharmacy ...
Xiang Q, Yang Y, Li G, Chen S, Yang Y, Liu L, Yu X   +6 more
doaj  

Immunomodulatory effects of a mycelium extract of Cordyceps (Paecilomyces hepiali; CBG-CS-2): a randomized and double-blind clinical trial

BMC Complementary and Alternative Medicine, 2019
Background Cordyceps is a traditional Chinese herb that produces various biopharmaceutical effects, including immune-enhancing effects. In this study, we prepared a Cordyceps mycelium culture extract (Paecilomyces hepiali, CBG-CS-2) to confirm its ...
Su-Jin Jung, Eun-Soo Jung, Eun-Kyung Choi, Hong-Sig Sin, Ki-Chan Ha, Soo-Wan Chae   +5 more
doaj   +1 more source

Proteo-genomic analyses in relatively lean Chinese adults identify proteins and pathways that affect general and central adiposity levels

Communications Biology
Adiposity is an established risk factor for multiple diseases, but the causal relationships of different adiposity types with circulating protein biomarkers have not been systematically investigated.
Andri Iona, Pang Yao, Alfred Pozarickij, Christiana Kartsonaki, Saredo Said, Neil Wright, Kuang Lin, Iona Millwood, Hannah Fry, Mohsen Mazidi, Baihan Wang, Yiping Chen, Huaidong Du, Ling Yang, Daniel Avery, Dan Schmidt, Dianjianyi Sun, Pei Pei, Jun Lv, Canqing Yu, Michael Hill, Junshi Chen, Fiona Bragg, Derrick Bennett, Robin Walters, Liming Li, Robert Clarke, Zhengming Chen, China Kadoorie Biobank Collaborative Group   +28 more
doaj   +1 more source

Jingfang Granules for prevention of alcohol-induced hangover: a randomized, double-blind, crossover trial in healthy volunteers

Frontiers in Pharmacology
IntroductionJingfang Granules (JFG), a classical traditional Chinese medicine formula comprising 11 botanical drugs, have traditionally been prescribed to dispel cold and eliminate dampness. This study aimed to clinically evaluate the efficacy and safety
Feng Wu, Yuyang Dai, Siyang Ni, Jing Zhang, Xiaojun Hu, Ying Han, Ying Jiao, Huan Lu, Laichun Lu   +8 more
doaj   +1 more source

Patient and public involvement and engagement in the ASCEND PLUS trial: reflections from the design of a streamlined and decentralised clinical trial

Trials
Introduction ASCEND PLUS is a randomised controlled trial assessing the effects of oral semaglutide on the primary prevention of cardiovascular events in around 20,000 individuals with type 2 diabetes in the UK.
Muram El-Nayir, Rohan Wijesurendra, David Preiss, Marion Mafham, Leandros Tsiotos, Sadman Islam, Anne Whitehouse, Sophia Wilkinson, Hannah Freeman, Ryonfa Lee, Wojciech Brudlo, Genna Bobby, Bryony Jenkins, Robert Humphrey, Amy Mallorie, Andrew Toal, Elnora C. Barker, Dianna Moylan, Graeme Thomson, Firoza Davies, Hameed Khan, Ian Allotey, Susan Dickie, John Roberts   +23 more
doaj   +1 more source

Clinical Trials and Clinical Judgment

Journal of the American College of Cardiology, 2008
![Figure][1] Cardiovascular specialists have become justifiably proud of their commitment to evidence-based medicine and clinical trials. More large-scale randomized prospective clinical trials (RCTs) are performed in cardiology than in any other field, and contemporary practice is ...
openaire   +2 more sources

Study on bioequivalence and influence of obesity-related indicators on pharmacokinetics and pharmacodynamics for insulin degludec in healthy subjects

Scientific Reports
This study aimed to evaluate the bioequivalence between test and reference insulin degludec (IDeg) and the effects of body composition on pharmacokinetics and pharmacodynamics of IDeg in Chinese healthy volunteers.
Rui Su, Lei Wan, Yi Tao, Mingxue Zhu, Junliang Pu, Zhongping Li, Yuan Chen, Chengyong Tang   +7 more
doaj   +1 more source

Evaluation of drug-drug interaction between Suraxavir Marboxil (GP681) and itraconazole, and assessment of the impact of gene polymorphism

Frontiers in Pharmacology
IntroductionSuraxavir Marboxil (GP681) is a prodrug metabolized to GP1707D07, which inhibits influenza viral replication by targeting cap-dependent endonuclease through a single oral dose.
Mai Han, Gang Cui, Yan Zhao, Xianbo Zuo, Xiaoxue Wang, Xin Zhang, Na Mi, Jiangli Jin, Chunyan Xiao, Jing Wang, Wei Wu, Yajuan Li, Jintong Li   +12 more
doaj   +1 more source

A phase I, randomized study to evaluate the safety, tolerability, and pharmacokinetics of mefunidone in healthy subjects

Frontiers in Pharmacology
BackgroundMefunidone is a novel synthetic compound and is better when compared to pirfenidone for the anti-fibrotic treatment of renal fibrosis in end-stage renal disease.
Mai Han, Bishan Huo, Gaoyun Hu, Xin Zhang, Gang Cui, Wei Wu, Na Mi, Shixi Zhang, Jiangli Jin, Xing Lu, Bidong Wu, Chunyan Xiao, Jing Wang, Zheng Bian, Jintong Li   +14 more
doaj   +1 more source