Results 31 to 40 of about 9,816,425 (315)

Strengthening and stretching for rheumatoid arthritis of the hand (SARAH): design of a randomised controlled trial of a hand and upper limb exercise intervention - ISRCTN89936343 [PDF]

, 2012
Background: Rheumatoid Arthritis (RA) commonly affects the hands and wrists with inflammation, deformity, pain, weakness and restricted mobility leading to reduced function.
Toye, Francine, Lamb, S. E. (Sallie E.), Williamson Esther M, Adams, Jo, Nichols, Vivien P., Heine Peter, McConkey Christopher, Mark A Williams, Nicols, Vivien, Underwood, Martin, Bridle, Christopher, Bridle, C, Lord, J, Bridle, Chris, Esther M Williamson, Joanne Lord, Heine, Peter, Williamson, Esther, Christopher McConkey, Williams, MA, Lamb, Sarah, null null, Heine, Peter J., Dosanjh Sukhdeep, Adams Jo, Francine Toye, Lamb Sarah E, Williams, Mark A., Sukhdeep Dosanjh, Lamb, SE, Chris Bridle, McConkey, Christopher C., Toye, F, Nichols Vivien, Heine, P, Underwood Martin R, Toye Francine, HASH(0x55a6805dc180), Bridle Chris, Williamson, EM, Martin R Underwood, Williams Mark A, Dosanjh, S, Underwood, MR, Jo Adams, Adams, J, Lord, J., McConkey, Christopher, Vivien Nichols, Sarah Trial Team, The, Lord, Joanne, Williams, Mark, Lord Joanne, Dosanjh, Sukhdeep, Nichols, V, Sarah E Lamb, McConkey, C, Peter Heine, Williamson, Esther M.   +58 more
core   +2 more sources

The prevention and treatment of COVID-19 in patients treated with hemodialysis

European Journal of Medical Research, 2023
Patients treated with hemodialysis are often immunocompromised due to concomitant disease. As a result, this population is at high risk of infection and mortality from COVID-19.
Binyu Zeng, Jia Zhou, Daizhuang Peng, Chengmei Dong, Qun Qin   +4 more
doaj   +1 more source

The Beta Agonist Lung Injury TrIal (BALTI) : prevention trial protocol [PDF]

, 2011
Background: Acute lung injury complicates approximately 25-30% of subjects undergoing oesophagectomy. Experimental studies suggest that treatment with beta agonists may prevent the development of acute lung injury by decreasing inflammatory cell ...
Matthew W Cooke, Thickett, David R, Lamb, S. E. (Sallie E.), Thickett David R, David R Thickett, Cooke, Matthew (Professor of clinical systems design), Lamb, Sarah E, Perkins, Gavin D., Daniel Park, Mistry Dipesh, Fang Gao, Gao, Fang; id_orcid, Alderson, Derek, Cooke Matthew W, Gao Fang, Dipesh Mistry, Alderson Derek, Gao, Fang, Mistry, Dipesh, Park, Daniel P., Park Daniel, Cooke, Matthew W, Thickett, David R; id_orcid, Gates, Simon, Sarah E Lamb, Park, Daniel, Gavin D Perkins, Perkins, Gavin D, Simon Gates, Thickett, David R., Smith, F. Gao (Fang Gao), Gates Simon, Lamb Sarah E, Derek Alderson, Perkins Gavin D   +34 more
core   +3 more sources

Informed consent and placebo effects: a content analysis of information leaflets to identify what clinical trial participants are told about placebos [PDF]

, 2012
BackgroundPlacebo groups are used in randomised clinical trials (RCTs) to control for placebo effects, which can be large. Participants in trials can misunderstand written information particularly regarding technical aspects of trial design such as ...
Alison E. M. Adams (317941), George T. Lewith (317942), Kaptchuk, Ted J., Ted J Kaptchuk, Ted J. Kaptchuk (234474), Bishop Felicity L., Lewith George T., Adams, Alison E. M., Kaptchuk, Ted, Bishop, Felicity L., Felicity L. Bishop (317940), Adams Alison E. M., Alison E M Adams, Kaptchuk Ted J., Lewith, George, Lewith, George T., Felicity L Bishop, Adams, Alison E.M., George T Lewith   +18 more
core   +1 more source

Tanshinone ΙΙA-Incubated Mesenchymal Stem Cells Inhibit Lipopolysaccharide-Induced Inflammation of N9 Cells through TREM2 Signaling Pathway

Stem Cells International, 2022
Our previous study found that incubating mesenchymal stem cells (MSC) with tanshinone IIA (TIIA) before transplantation could significantly increase the inhibitory effect of MSC on neuroinflammation.
Nanqu Huang, Juan Huang, Fei Feng, Zhisheng Ba, Yuanyuan Li, Yong Luo   +5 more
doaj   +1 more source

Does it matter if clinicians recruiting for a trial don't understand what the trial is really about? Qualitative study of surgeons' experiences of participation in a pragmatic multi-centre RCT. [PDF]

, 2007
Background Qualitative methods are increasingly used to study the process of clinical trials and patients understanding of the rationale for trials, randomisation and reasons for taking part or refusing.
Snowdon, Claire, Fairbank, Jeremy, Barker Karen, Fairbank Jeremy, Helen Frost, Fairbank, Jeremy C T, Featherstone Katie, Katie Featherstone, Jeremy Fairbank, Sue Ziebland, Frost, Helen, Snowdon, C, Snowdon Claire, Barker, K, Barker, Karen, Featherstone, Katie, Claire Snowdon, Ziebland, S, Ziebland Sue, Featherstone, K, Ziebland, Sue B, Frost Helen, Ziebland, Sue, Frost, H, Karen Barker   +24 more
core   +4 more sources

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Ethical and scientific considerations for patient enrollment into concurrent clinical trials. [PDF]

, 2014
Researchers and institutional review boards often consider it inappropriate for patients to be asked to consent to more than one study despite there being no regulatory prohibition on co-enrollment in most countries.
Williamson, Elizabeth, Oakley, Justin, Justin Oakley, Andrew Forbes, Myles, Paul S, Elizabeth Williamson, Forbes, Andrew, Paul S Myles   +7 more
core   +2 more sources

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source