Results 21 to 30 of about 9,816,425 (315)

Development of a PBPK model to quantitatively understand absorption and disposition mechanism and support future clinical trials for PB‐201

CPT: Pharmacometrics & Systems Pharmacology, 2023
PB‐201 is the second glucokinase activator in the world to enter the phase III clinical trials for the treatment of type 2 diabetes mellitus (T2DM).
Miao Zhang, Zihan Lei, Ziheng Yu, Xueting Yao, Haiyan Li, Min Xu, Dongyang Liu   +6 more
doaj   +1 more source

Participants' preference for type of leaflet used to feed back the results of a randomised trial: a survey [PDF]

, 2010
Background\ud Hundreds of thousands of volunteers take part in medical research, but many will never hear from researchers about what the study revealed.
Brealey, Stephen, Russell Ian, Stephen Brealey, Fiona Fylan, Gillan, M, Helen Cox, Houston, H, Russell, I, Gillan, Maureen, Hendry, Maggie, Maggie Hendry, Christine Atwell, Gillan Maureen, King, David C., Cox Helen, Atwell, Christine, Gilbert Fiona, Robling Michael, Helen Houston, Russell, Ian, Dennis, Laura, Fylan, Fiona, Cross, Ben, Adronis, Lazaros, Robling, M, Gilbert, Fiona, Wilkinson Clare, Andrew Garratt, Clare Wilkinson, Michael Robling, Bryan, Stirling, David King, Lazaros Andronis, Wilkinson, Clare, Cox, Helen, Brealey Stephen, Coulton, Simon, Bryan, S, Coulton, S, Cox, H, Fylan Fiona, Andronis Lazaros, Ben Cross, Wilkinson, C, Garratt, Andrew, Coulton Simon, Brealey, S, Cross, B, Laura Dennis, Kerenza Hood, Morton, Veronica, Fiona Gilbert, Dennis, L, Garratt Andrew, Cross Ben, Ian Russell, Houston Helen, Andronis, L, Houston, Helen, King David, Maureen Gillan, Atwell Christine, Hendry, M, Morton Veronica, Morton, V, Rusell, Ian, King, D, Atwell, C, Gilbert, F, Andronis, Lazaros, King, David G, Houston, Helen Louise Ann, Stirling Bryan, Robling, Michael, Simon Coulton, Brealey, SD, Hood, K, King, David, Garratt, A, Fylan, F, Hendry Maggie, Bryan Stirling, Wilkinson, Clare Elizabeth, Dennis Laura, Hood, Kerenza, Hood Kerenza, Veronica Morton   +86 more
core   +3 more sources

Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in acute lung injury to reduce pulmonary dysfunction (HARP-2) trial : study protocol for a randomized controlled trial [PDF]

, 2012
Acute lung injury (ALI) is a common devastating clinical syndrome characterized by life-threatening respiratory failure requiring mechanical ventilation and multiple organ failure.
O'Kane, Cecilia M., O’Kane, Cecilia M., Laffey, John G, Cross, Mark, John G Laffey, McAuley, Daniel F; id_orcid, McNally, Christine, Michael Stevenson, Perkins, Gavin D., Crealey, Grainne, Laffey, John G., Daniel F McAuley, Murphy, Lynn, HASH(0x55a67ff73468), Stevenson, Michael, Cross, L. J. Mark, Grainne Crealey, Cecilia M O’Kane, McAuley, Daniel F., Mark Cross, null null, Gavin D Perkins, Perkins, Gavin D, Christine McNally, Lynn Murphy, O'Kane, Cecilia M, Cross Mark, Stevenson Michael, Murphy Lynn, McNally Christine, Crealey Grainne, Laffey John G, O’Kane Cecilia M, McAuley Daniel F, Perkins Gavin D, McAuley, Daniel F, and the HARP-2 investigators on behalf of the Irish Critical Care Trials Group, O’Kane, Cecilia M   +37 more
core   +2 more sources

Managing clinical trials. [PDF]

, 2010
Managing clinical trials, of whatever size and complexity, requires efficient trial management. Trials fail because tried and tested systems handed down through apprenticeships have not been documented, evaluated or published to guide new trialists ...
Barbara Farrell, Shakur Haleema, Farrell Barbara, Haleema Shakur, Farrell, B, Kenyon, Sara, Shakur, Haleema, Kenyon, Sara; id_orcid, Shakur, H, Kenyon Sara, Sara Kenyon, Farrell, Barbara   +11 more
core   +2 more sources

A statistical framework for quantifying clinical equipoise for individual cases during randomized controlled surgical trials [PDF]

, 2011
Background Randomised controlled trials are being increasingly used to evaluate new surgical interventions. There are a number of problematic methodological issues specific to surgical trials, the most important being identifying whether patients are ...
Girling, Alan, Girling Alan, Parsons, Nicholas R., Parsons, NR, Alan Girling, Griffin Damian, Girling, Alan J., Yuri Kulikov, Kulikov Yuri, Damian Griffin, Parsons Nicholas R, Griffin, Damian R., Griffin, D, Kulikov, Y, Kulikov, Yuri, Nicholas R Parsons   +15 more
core   +2 more sources

Research ethics consultation: an attempt and 5-year experience in a Japanese University Hospital

BMC Research Notes, 2018
Objective Research ethics consultation is an advisory activity that differs from ethics committees, and its role is not yet widely known in Japan. Research ethics consultations were started in 2012 by members of the Clinical Trial Center of Tokushima ...
Hiroaki Yanagawa, Rumi Katashima, Chiho Sato, Kenshi Takechi, Hiroshi Nokihara, Chikako Kane, Masayuki Chuma, Yuki Aoe   +7 more
doaj   +1 more source

Clinical Trial Results: A Clinical Trial Bazaar! [PDF]

The Oncologist, 2014
The Oncologist's Clinical Trial Results section welcomes both positive and negative results in an effort to share information, speed discovery, and inform the field. Clinical Trial Results submissions have shown how succinctly the salient features of a submission can be presented, with more in-depth information to be found online.
Antonio Tito, Fojo, Susan E, Bates
openaire   +2 more sources

Evaluation of the clinical and cost effectiveness of intermediate care clinics for diabetes (ICCD) : a multicentre cluster randomised controlled trial [PDF]

, 2014
Background: Configuring high quality care for the rapidly increasing number of people with type 2 diabetes (T2D) is a major challenge worldwide for both providers and commissioners.
Joseph Paul O’Hare, P. Saravanan (2679490), Saravanan, Ponnusamy, Baines Darrin, Khunti, Kamlesh, Andrew Wilson, Hardy, Ainsley, Joseph Paul O’Hare (552525), Ala Szczepura (83137), Darrin Baines (552528), Saravanan Ponnusamy, Sudhesh Kumar (89490), O’Hare Joseph Paul, Ric Crossman (552527), Andrew Wilson (23322), Khunti Kamlesh, Kamlesh Khunti, Hardy, Ainslea, Wilson Andrew, Hardy Ainsley, Crossman, Richard, Ala Szczepura, ICCD trial group (7628486), Wilson, Andrew, Crossman Ric, A. Szczepura (7628477), ICCD trial group, Darrin Baines, Ponnusamy Saravanan (552529), Raymond Neil, Raymond, Neil T., J. P. O'Hare (7628471), N. Raymond (7628474), Baines, Darrin L., Ainsley Hardy, Ainsley Hardy (552526), Kumar Sudhesh, Sudhesh Kumar, Baines, Darrin, Joseph Paul O'Hare, Neil Raymond, Neil Raymond (438247), Szczepura, Ala, Crossman, Ric, Kumar, Sudhesh, Kamlesh Khunti (171607), S. Kumar (746162), Raymond, Neil, Szczepura Ala, D. Baines (7628483), R. Crossman (7628480), O’Hare, Joseph Paul, O'Hare, J. Paul, Ric Crossman, Ponnusamy Saravanan   +54 more
core   +1 more source

A randomized multicenter clinical trial to evaluate the efficacy of melatonin in the prophylaxis of SARS-CoV-2 infection in high-risk contacts (MeCOVID Trial): A structured summary of a study protocol for a randomised controlled trial

Trials, 2020
Objectives Primary objective: to evaluate the efficacy of melatonin as a prophylactic treatment on prevention of symptomatic SARS-CoV-2 infection among healthcare workers at high risk of SARS-CoV-2 exposure. Secondary objectives: To evaluate the efficacy
Irene García García, Miguel Rodriguez-Rubio, Amelia Rodríguez Mariblanca, Lucía Martínez de Soto, Lucía Díaz García, Jaime Monserrat Villatoro, Javier Queiruga Parada, Enrique Seco Meseguer, María J. Rosales, Juan González, José R. Arribas, Antonio J. Carcas, Pedro de la Oliva, Alberto M. Borobia   +13 more
doaj   +1 more source

Novel indicator for the spread of new coronavirus disease 2019 and its association with human mobility in Japan

Scientific Reports, 2023
The Japanese government adopted policies to control human mobility in 2020 to prevent the spread of severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019 (COVID-19). The present study examined the impact of human mobility
Yuta Kawakami, Shuko Nojiri, Daisuke Nakamoto, Yoshiki Irie, Satoshi Miyazawa, Manabu Kuroki, Yuji Nishizaki   +6 more
doaj   +1 more source