Results 21 to 30 of about 1,889,174 (167)

CD39 and CD73: biological functions, diseases and therapy

Molecular Biomedicine
Cluster of differentiation 39 (CD39) and CD73 are ectonucleotidases that play pivotal roles in purinergic signaling. CD39 catalyzes the hydrolysis of adenosine triphosphate (ATP) to adenosine diphosphate (ADP) and subsequently to adenosine monophosphate (
Jie Shen, Bin Liao, Li Gong, Sha Li, Juan Zhao, Huiyao Yang, Yi Gong, Yongsheng Li   +7 more
doaj   +1 more source

Clinical characteristics and treatment outcomes of HER2 mutation and HER2 fusion in 22 patients with advanced breast cancer

Thoracic Cancer, 2023
Background The clinical characteristics and efficacy of human epidermal growth factor receptor‐2 (HER‐2)‐directed agents against HER2 mutations and HER2 fusions in breast cancer are obscure due to their low frequency. Methods We conducted a retrospective
Yuxin Mu, Yanchun Meng, Yiqun Du, Xiaojun Liu, Jian Zhang   +4 more
doaj   +1 more source

Building games into multicenter clinical trial systems to boost trial engagement

Trials
Background Workplace gamification refers to the translation of ordinary work tasks into a fun thematic framework—using game design elements such as points, competition, and recognition—to enhance engagement and motivation. Clinical trials are lengthy and
Ryan Majkowski, Shannon Hillery, Bradley J. Barney, Paul Ryu, Esther Woo, Nichol McBee, Andrew Mould, Lindsay M. Eyzaguirre, Elizabeth Holthouse, Karen Lane   +9 more
doaj   +1 more source

Bullous Systemic Lupus Erythematosus: Clinical Presentation in Two Asian Cases

Case Reports in Medicine
Bullous systemic lupus erythematosus (BSLE) is a rare subset of systemic lupus erythematosus (SLE), characterized by the rapid onset of vesiculobullous lesions that primarily affect sun-exposed areas of the body.
Phuong Thi Thanh Nguyen, Thuy Thi Phan Nguyen, Hoang Vu Nguyen, Anh Thi Minh Nguyen, Nhi Thi Uyen Pham   +4 more
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Pharmacokinetic and bioequivalence of two formulations of Valsartan/Amlodipine Tablet(I) in healthy Chinese volunteers: A randomized, three-period, partially replicated crossover study

Scientific Reports
Valsartan/amlodipine combination tablets can exert synergistic antihypertensive effects through different mechanisms, significantly lowering blood pressure while also addressing multiple risk factors and comorbidities in patients.
Yingying Mei, Xu Zuo, Tiandong Zhang, Ziyun Bu, Zhendan Xu   +4 more
doaj   +1 more source

The impact of clinical trial units on the value of clinical research in Switzerland

Swiss Medical Weekly, 2018
A prominent 2014 series by The Lancet on “Increasing value, reducing waste in biomedical research” provided recommendations on how to optimise precious resources, including in clinical research.
Belinda von Niederhäusern, Annette Magnin, Christiane Pauli-Magnus   +2 more
doaj   +1 more source

Comparative Lipid-Lowering/Increasing Efficacy of 7 Statins in Patients with Dyslipidemia, Cardiovascular Diseases, or Diabetes Mellitus: Systematic Review and Network Meta-Analyses of 50 Randomized Controlled Trials

Cardiovascular Therapeutics, 2020
Objective. The drug efficacy may differ among different statins, and evidence from head-to-head comparisons is sparse and inconsistent. The study is aimed at comparing the lipid-lowering/increasing effects of 7 different statins in patients with ...
Xiaodan Zhang, Lu Xing, Xiaona Jia, Xiaocong Pang, Qian Xiang, Xia Zhao, Lingyue Ma, Zhiyan Liu, Kun Hu, Zhe Wang, Yimin Cui   +10 more
doaj   +1 more source

Clinical Medicine and Clinical Trials [PDF]

The Oncologist, 2010
The author discusses the role of clinical trials in clinical medicine.
openaire   +2 more sources

Developing a quality indicator system for pediatric clinical trials management of research centers in China: a modified Delphi-Analytic Hierarchy Process study

BMC Pediatrics
Background Pediatric clinical trials face many challenges that hinder the development of safe and effective pediatric drugs. Enhancing risk control and management quality of pediatric clinical trials in research centers is essential to address these ...
Chang Liu, Yi Liu, Bo Xuan, Yuenan Qi, Ling Ou, Jianmin Zhang   +5 more
doaj   +1 more source

Pharmacokinetics, Relative Bioavailability, and Safety of the SHR0302 Oral Solution and Tablets: A Single-Center, Randomized, Open-Label, Crossover (Two-Formulation, Two-Period) Phase I Trial in Healthy Chinese Volunteers

Drug Design, Development and Therapy
Xin Gao,1 Kai Shen,2 Dan Tang,2 Wenjing Bai,1 Juan Wang,1 Tingting Wang,1 Xin Wang1 1Clinical Trial Center, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Key Laboratory of ...
Gao X, Shen K, Tang D, Bai W, Wang J, Wang T, Wang X   +6 more
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