Results 11 to 20 of about 1,889,174 (167)

Clinical Trial Results: A Clinical Trial Bazaar! [PDF]

The Oncologist, 2014
The Oncologist's Clinical Trial Results section welcomes both positive and negative results in an effort to share information, speed discovery, and inform the field. Clinical Trial Results submissions have shown how succinctly the salient features of a submission can be presented, with more in-depth information to be found online.
Antonio Tito, Fojo, Susan E, Bates
openaire   +2 more sources

The prevention and treatment of COVID-19 in patients treated with hemodialysis

European Journal of Medical Research, 2023
Patients treated with hemodialysis are often immunocompromised due to concomitant disease. As a result, this population is at high risk of infection and mortality from COVID-19.
Binyu Zeng, Jia Zhou, Daizhuang Peng, Chengmei Dong, Qun Qin   +4 more
doaj   +1 more source

Tanshinone ΙΙA-Incubated Mesenchymal Stem Cells Inhibit Lipopolysaccharide-Induced Inflammation of N9 Cells through TREM2 Signaling Pathway

Stem Cells International, 2022
Our previous study found that incubating mesenchymal stem cells (MSC) with tanshinone IIA (TIIA) before transplantation could significantly increase the inhibitory effect of MSC on neuroinflammation.
Nanqu Huang, Juan Huang, Fei Feng, Zhisheng Ba, Yuanyuan Li, Yong Luo   +5 more
doaj   +1 more source

Safety and Tolerability of an Antimalarial Herbal Remedy in Healthy Volunteers: An Open-Label, Single-Arm, Dose-Escalation Study on Maytenus senegalensis in Tanzania

Tropical Medicine and Infectious Disease, 2022
Background: Though Maytenus senegalensis is one of the medicinal plants widely used in traditional medicine to treat infectious and inflammatory diseases in Africa, there is a lack of safety data regarding its use.
Kamaka Kassimu, Florence Milando, Justin Omolo, Abel Mdemu, Gloria Nyaulingo, Hussein Mbarak, Latipha Mohamed, Ramla Rashid, Saumu Ahmed, Mohammed Rashid, Hania Msami, David Damiano, Beatus Simon, Thabit Mbaga, Fatuma Issa, Omar Lweno, Neema Balige, Omary Hassan, Bakari Mwalimu, Ali Hamad, Ally Olotu, Andreas Mårtensson, Francis Machumi, Said Jongo, Billy Ngasala, Salim Abdulla   +25 more
doaj   +1 more source

Safety, tolerability, and pharmacokinetics of CG2001 in Chinese adult male subjects with androgenetic alopecia: a randomized, double-blind, placebo-controlled, single- and multi-doses, phase 1 clinical study

Journal of Dermatological Treatment
Objectives Compared with placebo, this phase I study evaluated the safety, tolerability, and pharmacokinetics of CG2001, a novel isopropyl alcohol-free minoxidil-finasteride combination topical foam, in Chinese males with androgenetic alopecia (AGA ...
Yanting Li, Baohui Yu, Suping Niu, Ziyan Ding, Qun Gu, Hui Zhang, Rui Ding, Cheng Zhou, Fang Men, Yian Liu, Wenyan Zhao, Liming Chen, Shuang Li, Qian Wang, Meng Xiao, Fan Huang, Binyi Hu, Jiaojiao Zhang, Jianzhong Zhang, Yi Fang   +19 more
doaj   +1 more source

Participant recruitment and retention in a longitudinal study: experience from SARS-CoV-2 cohort in Ethiopia

BMC Medical Research Methodology
Background Longitudinal cohort studies are essential for understanding changes in health over time, yet participant recruitment and retention remain major challenges, especially in low-resource settings. This study describes the strategies, outcomes, and
Eyob Girma Abera, Yeneneh Berhanu Kebede, Zeleke Alemu Adulo, Neway Tadesse Tilahun, Bikila Alemu Kebede, Zerihun Asefa Hordofa, Wondimagegn Adissu Maleko, Daniel Yilma, Esayas Kebede Gudina   +8 more
doaj   +1 more source

Safety, pharmacokinetics and pharmacodynamics of a novel γ-aminobutyric acid (GABA) receptor potentiator, HSK3486, in Chinese patients with hepatic impairment

Annals of Medicine, 2022
Background The primary objective of this study was to investigate if hepatic impairment alters the safety, pharmacokinetics, and pharmacodynamics of HSK3486.Research design and methods This was a clinical trial of HSK3486 in subjects with normal hepatic ...
Yue Hu, Xiaojiao Li, Jingrui Liu, Hong Chen, Wenbo Zheng, Hong Zhang, Min Wu, Cuiyun Li, Xiaoxue Zhu, Jinfeng Lou, Pangke Yan, Nan Wu, Xiao Liu, Shiping Ma, Xu Wang, Yanhua Ding, Chengluan Xuan   +16 more
doaj   +1 more source

Generating evidence on a risk-based monitoring approach in the academic setting – lessons learned

BMC Medical Research Methodology, 2017
Background In spite of efforts to employ risk-based strategies to increase monitoring efficiency in the academic setting, empirical evidence on their effectiveness remains sparse.
Belinda von Niederhäusern, Annette Orleth, Sabine Schädelin, Nawal Rawi, Martin Velkopolszky, Claudia Becherer, Pascal Benkert, Priya Satalkar, Matthias Briel, Christiane Pauli-Magnus   +9 more
doaj   +1 more source

A study on the pharmacokinetic bioequivalence of oral tablet formulations of riluzole among healthy volunteers utilizing HPLC-MS/MS

BMC Pharmacology and Toxicology
Introduction This randomized, open-label, two period, two treatment, fasting bioequivalence trial was conducted to demonstrate the bioequivalence between riluzole tablets manufactured by Jiangsu Enhua Pharmaceutical Co., Ltd.
Fei Yu, Rui Wang, Keli Wang, BoYang Lin, Xuan Zhou, Linghong Chen, Li Ma, Zheng Liao, Wanggang Zhang   +8 more
doaj   +1 more source

Clinical Trials and the Role of the Oncology Clinical Trials Nurse [PDF]

Nursing Clinics of North America, 2017
Clinical trials are paramount to improving human health. New trial designs and informed consent issues are emerging as a result of genomic profiling and the development of molecularly targeted agents. Many groups and individuals are responsible for ensuring the protection of research participants and the quality of the data produced. The specialty role
Elizabeth A, Ness, Cheryl, Royce
openaire   +2 more sources