Results 11 to 20 of about 9,816,425 (315)

Considerations on the Obstacles That Lead to Slow Recruitment in a Pain Management Clinical Trial: Experiences from the Belgian PELICAN (PrEgabalin Lidocaine Capsaicin Neuropathic Pain) Pragmatic Study

Pain Research and Management, 2023
Background. A qualitative evaluation study of the prematurely terminated PrEgabalin Lidocaine Capsaicin Neuropathic Pain (PELICAN) study was performed.
Guy H. Hans, Dima Almeshal, Lotte Vanlommel, Ella Roelant, Iris Verhaegen, Elke Smits, Koen Van Boxem, Robert Fontaine, The PELICAN Investigators Team   +8 more
doaj   +1 more source

Development and Validation of a Prediction Model for Venous Thrombus Embolism (VTE) in Patients With Colorectal Cancer

Technology in Cancer Research & Treatment, 2023
Cancer patients are at high risk of developing venous thromboembolism (VTE). The risk of VTE could be mitigated with the administration of prophylactic anticoagulants.
Wei-Juan Tan MS, Lu Chen MS, Sheng-Jie Yang MD, Bao-Ying Zhang MD, Ming-Li Sun MD, Yu-Bin Lin MS, Xing-He Wang MD, PhD   +6 more
doaj   +1 more source

Feasibility of simple exercise interventions for men with osteoporosis – A prospective randomized controlled pilot study

Bone Reports, 2021
Background: Aging is associated with progressive loss of musculoskeletal performance. Exercise interventions can improve physical function in the elderly but there is a paucity of comparative assessments in order to understand what specific goals can be ...
Franca Genest, Sarah Lindström, Sophia Scherer, Michael Schneider, Lothar Seefried   +4 more
doaj   +1 more source

Multicentre randomised controlled trial of nasal diamorphine for analgesia in children and teenagers with clinical fractures. [PDF]

, 2001
OBJECTIVE: To compare the effectiveness of nasal diamorphine spray with intramuscular morphine for analgesia in children and teenagers with acute pain due to a clinical fracture, and to describe the safety profile of the spray.
Latter, VS, Nasal Diamorphine Trial Group, Reeves, BC, Kendall, JM   +3 more
core   +1 more source

Effect of a high‐fat and high‐calorie food on the pharmacokinetics of a novel, potent GABA analog HSK16149 in healthy subjects

Pharmacology Research & Perspectives, 2023
HSK16149 is a novel, potent gamma‐aminobutyric acid (GABA) analog for the treatment of neuropathic pain. The purpose of this study was to assess the effect of a high‐fat and high‐calorie meal on the pharmacokinetics of HSK16149 in healthy Chinese ...
Qingqing Wu, Huijuan Zhu, Rong Song, Mengqi Zhang, Fangqiong Li, Weifang Zeng, Wei Wang, Jingying Jia, Chen Yu, Yanmei Liu   +9 more
doaj   +1 more source

Society for Cardiovascular Magnetic Resonance (SCMR) expert consensus for CMR imaging endpoints in clinical research : part I - analytical validation and clinical qualification [PDF]

, 2018
Cardiovascular disease remains a leading cause of morbidity and mortality globally. Changing natural history of the disease due to improved care of acute conditions and ageing population necessitates new strategies to tackle conditions which have more ...
Greenwood, J.P., Puntmann, V.O., R Hinojar (7703975), Petersen, SE, Petersen, S.E., Neubauer, Stefan, Bucciarelli-Ducci, C, McCann, Gerry P., Nagel, E, John P. Greenwood, E Nagel (7687181), Valbuena, Silvia, Petersen, Steffen Erhard, Petersen, Steffen E., Valbuena, S., Simonetti, O, Westenberg, JJ, JP Greenwood (7692707), SCMR Clinical Trial Writing Group (7703990), Nagel, Eike, Kwong, RY, Young, AA, on behalf of SCMR Clinical Trial Writing Group, Kramer, Christopher M., Valbuena, S, Botnar, R, Lombardi, M, Puntmann, VO, Plein, S, Kwong, Raymond Y., Hundley, G, Puntmann, Valentina O., Lopez Fernandez, T, Sanz, J, Prasad, S, Rademakers, F, S Valbuena (7703972), Raman, S, SE Petersen (7703978), Kramer, CM, Teixeira, T, Nagel, E., Choudhury, RP, Taylor, AJ, Hinojar, R, Gerry P. McCann, McCann, GP, SCMR Clinical Trial Writing Group, Greenwood, JP, Marwick, T, Dweck, M, Eitel, I, Steffen E. Petersen, Kramer, C.M., Kwong, R.Y., GP McCann (7687148), Ugander, M, RY Kwong (7703984), CM Kramer (7703981), Narula, J, Colin Berry, Thiele, H, Hinojar, Rocio, Bremerich, J, McCann, G.P., Valentina O. Puntmann, C Berry (7703987), Patel, A, Berry, Colin, Schulz-Menger, J, Berry, C, Raymond Y. Kwong, Berry, C., Neubauer, S, Friedrich, M, Rocio Hinojar, Greenwood, John P., Ferrari, V, Silvia Valbuena, VO Puntmann (7703969), Sakuma, H, Hinojar, R., Bluemke, D, Swift, A, Eike Nagel, Christopher M. Kramer, Pennell, D, McCann, Gerry P, Kwong, Raymond Y, Greenwood, John P, Puntmann, Valentina O, Kramer, Christopher M, Petersen, Steffen E   +92 more
core   +1 more source

Co-expression and prognosis analyses of GLUT1–4 and RB1 in breast cancer

BMC Cancer, 2021
Background Current treatment methods for patients with triple-negative breast cancer (TNBC) are very limited, and the prognosis of TNBC is relatively poor.
Xiaodan Zhang, Xiaocong Pang, Zhuo Zhang, Qianxin Liu, Hanxu Zhang, Qian Xiang, Yimin Cui   +6 more
doaj   +1 more source

Differential impact of osteoporosis, sarcopenia and obesity on physical performance in aging men

Endocrine Connections, 2021
Purpose: Aging and concurrent constitutional changes as sarcopenia, osteoporosis and obesity are associated with progressive functional decline. Coincidence and mutual interference of this risk factors require further evaluation.
Franca Genest, Michael Schneider, Andreas Zehnder, Dominik Lieberoth-Leden, Lothar Seefried   +4 more
doaj   +1 more source

An adaptive seamless phase II/III clinical trial design incorporating short-term endpoint information [PDF]

, 2011
Adaptive seamless phase II/III designs enable a clinical trial to be conducted in stages with the most promising of a number of experimental treatments selected on the basis of data observed in the first stage to continue along with the control ...
Stallard, Nigel, Nigel Stallard, Stallard Nigel   +2 more
core   +1 more source

Proton Beam Therapy - the Challenges of Delivering High-quality Evidence of Clinical Benefit. [PDF]

, 2018
The use of proton beam therapy (PBT) offers the opportunity to improve greater conformality of radiotherapy treatment delivery in some patients. However, it is associated with a high capital cost and the need to build new dedicated facilities. We discuss
National Cancer Research Institute Clinical and Translational Radiotherapy Research Working Group (CTRad) Proton Beam Clinical Trial Strategy Group,
core   +2 more sources