Results 61 to 70 of about 9,816,425 (315)

The CRASH trial protocol (Corticosteroid randomisation after significant head injury) [ISRCTN74459797]. [PDF]

, 2001
BACKGROUND: Worldwide, millions of people are treated each year for significant head injury. A substantial proportion die, and many more are disabled.
The CRASH trial collaborators, The CRASH trial management group, null null   +2 more
core   +2 more sources

Bone Mineral Density After Contemporary Treatment for Acute Lymphoblastic Leukaemia: A Matched Cross‐Sectional Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Reduced bone mineral density (BMD) has been reported in survivors of childhood and young adult acute lymphoblastic leukaemia (ALL); however, data from cohorts treated with contemporary protocols and including matched controls remain limited.
Karen Schow Jensen, Mette Tiedemann Skipper, Niels Holtum Birkebæk, Kjeld Schmiegelow, Thomas Leth Frandsen, Bente Langdahl, Rikke Beck Jensen, Asger Roer Pedersen, Christian Mølgaard, Liv Andrés‐Jensen, Birgitte Klug Albertsen   +10 more
wiley   +1 more source

How to get all trials reported: audit, better data, and individual accountability. [PDF]

, 2015
Reflecting on the new WHO statement on clinical trial registration and reporting, Ben Goldacre proposes simple solutions for ensuring clinical trial results are made publicly ...
Goldacre, Ben, Ben Goldacre
core   +2 more sources

Clinical Trials and the Role of the Oncology Clinical Trials Nurse [PDF]

Nursing Clinics of North America, 2017
Clinical trials are paramount to improving human health. New trial designs and informed consent issues are emerging as a result of genomic profiling and the development of molecularly targeted agents. Many groups and individuals are responsible for ensuring the protection of research participants and the quality of the data produced. The specialty role
Elizabeth A, Ness, Cheryl, Royce
openaire   +2 more sources

Parents of Youth With Cancer Report on Their Psychosocial Care: iSTEPPP Survey Finds Alignment and Gaps With Standards

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The Standards for Psychosocial Care for Children with Cancer and Their Families guide the provision of comprehensive psychosocial care. Parallel to research characterizing implementation of the Standards from the perspective of providers, this study examines implementation of the Standards from the perspective of parents of youth ...
Emily M. Pariseau, Kimberly Buff, Michele A. Scialla, Kimberly S. Canter, Lori Wiener, Victoria Sardi‐Brown, Julia B. Tager, Kamyar Arasteh, Anne E. Kazak   +8 more
wiley   +1 more source

Chemotherapy for Spinal Cord Intramedullary Pediatric Low‐Grade Glioma—A Systematic Literature Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko, Segev Gabay, Jonathan Roth, Amit Ringel, Rina Dvir, Shlomi Constantini   +5 more
wiley   +1 more source

Sequential Allocation and Balancing Prognostic Factors in a Psychiatric Clinical Trial [PDF]

, 2008
In controlled clinical trials, each of several prognostic factors should be balanced across the trial arms. Traditional restricted randomization may be proved inadequate especially with small sample sizes.
Carlos A. B. Pereira, Basilio B. Pereira, Victor Fossaluza, Juliana B. Diniz, Euripedes C. Miguel   +4 more
core  

IMPLEmenting a clinical practice guideline for acute low back pain evidence-based manageMENT in general practice (IMPLEMENT) : cluster randomised controlled trial study protocol [PDF]

, 2008
Background: Evidence generated from reliable research is not frequently implemented into clinical practice. Evidence-based clinical practice guidelines are a potential vehicle to achieve this.
Denise A O'Connor, O'Connor Denise A, Mortimer, D, Grimshaw, J. M., Mortimer, D. S., Buchbinder Rachelle, Joanne E McKenzie, Duncan Mortimer, Green, Sally E., Spike Neil, Michie, S, Spike, N., Jeremy M Grimshaw, Francis, J., McKenzie, Joanne E., Buchbinder, Rachelle, French Simon D, Mortimer Duncan, McKenzie Joanne E, Simon D French, Francis, Jillian Joy, Schattner, P., Michie, S., Peter M Kent, Green, SE, Jill Francis, Neil Spike, Michie Susan, Grimshaw, JM, McKenzie, J. E., Kent, PM, French, Simon D., Spike, N, Schattner Peter, Kent, Peter M., Susan Michie, O'Connor, DA, Kent, P. M., Grimshaw Jeremy M, Spike, Neil, O'Connor, D. A., Mortimer, Duncan, Kent Peter M, O'Connor, Denise A., Rachelle Buchbinder, Peter Schattner, Michie, Susan, Francis Jill, McKenzie, JE, Schattner, P, Buchbinder, R., Grimshaw, Jeremy M., French, SD, Green Sally E, Sally E Green, Francis, J, Schattner, Peter, Green, S. E., Buchbinder, R, French, S. D.   +59 more
core   +2 more sources

CD39 and CD73: biological functions, diseases and therapy

Molecular Biomedicine
Cluster of differentiation 39 (CD39) and CD73 are ectonucleotidases that play pivotal roles in purinergic signaling. CD39 catalyzes the hydrolysis of adenosine triphosphate (ATP) to adenosine diphosphate (ADP) and subsequently to adenosine monophosphate (
Jie Shen, Bin Liao, Li Gong, Sha Li, Juan Zhao, Huiyao Yang, Yi Gong, Yongsheng Li   +7 more
doaj   +1 more source

Exercise Capacity, Physical Activity, Fatigue, and Neurocognitive Function in Adult Survivors of Childhood Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adult survivors of childhood acute lymphoblastic leukemia (ALL) are at risk of reduced exercise capacity, decreased physical activity levels, persistent fatigue, and neurocognitive deficits. The aim was to investigate exercise capacity and physical activity levels of adult survivors of childhood ALL and their associations with ...
Laura Jess, Gustaf Glavå, Simon Skau, Hans‐Georg Kuhn, Maria Bäck, Marianne Jarfelt   +5 more
wiley   +1 more source