Results 81 to 90 of about 9,816,425 (315)

Clinical Medicine and Clinical Trials [PDF]

The Oncologist, 2010
The author discusses the role of clinical trials in clinical medicine.
openaire   +2 more sources

Abatacept for Prophylaxis of Acute and Chronic Graft‐Versus‐Host‐Disease in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation—A Systematic Review and Meta‐Analysis of Cohort Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Graft‐versus‐host disease (GvHD) remains one of the most significant complications of hematopoietic stem cell transplantation (HSCT). Abatacept, a selective T‐cell costimulation modulator, is a relatively novel prophylactic agent, though pediatric data remain limited.
Matthijs D. Kruizinga, Anne B. Verbeek, Caroline A. Lindemans, Emilie P. Buddingh   +3 more
wiley   +1 more source

Acupuncture for chronic knee pain: a randomized clinical trial. [PDF]

, 2014
IMPORTANCE: There is debate about benefits of acupuncture for knee pain. OBJECTIVE: To determine the efficacy of laser and needle acupuncture for chronic knee pain.
McCrory, Paul, Williamson, Elizabeth, McCrory, P, Hinman, R S, Reddy, P, Reddy, Prasuna, Metcalf, B R, Bennell, KL, Metcalf, BR, Conaghan, P G, Pirotta, M, Relf, I, Crossley, K M, Crossley, Kay M, Kyriakides, Mary, Metcalf, Ben R, Bennell, Kim L, Kyriakides, M, Conaghan, PG, Novy, Kitty, Bennell, K L, Crossley, KM, Conaghan, Philip G, Harris, Anthony, Hinman, RS, Williamson, E, Novy, K, Harris, A, Hinman, Rana S, Relf, Ian, Forbes, A, Pirotta, Marie, Forbes, Andrew   +32 more
core   +1 more source

Repeated Moisturizer Use Narrows the Surface-to-Deep Hydration Gap over Time: The Hydration Gap Index (HGI)

Cosmetics
Skin hydration is not uniform: it is low at the surface and rises with depth, and the standard capacitance probe (Corneometer) samples only the outermost layer. How the surface–deep relationship evolves under repeated moisturizer use is not captured by a
Youngrin Kwag, Seok Hwan Oh, Sang hyun Kim, Ji Hwoon Baek, HuiJeong Jeong, YooRi Kang, Hongseok Kim, Wonkyu Hong   +7 more
doaj   +1 more source

Bone and Soft Tissue Neoplasms in Infants Versus Older Children: A Report From the Cancer in Young People in Canada Program

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Infant bone and soft tissue neoplasms present distinct clinical challenges and lack large‐scale data to inform treatment decisions. This study aims to characterize bone and soft tissue neoplasms in infants in Canada and to compare their outcomes with those of older pediatric patients.
Samuel Sassine, Hallie Coltin, Maria Kondyli, Monia Marzouki, Nicolas Prud'homme, Nida Usmani, Rebecca J. Deyell, Lesleigh Abbott, Tony H. Truong, Sapna Oberoi, Ketan Kulkarni, Josée Brossard, Lynette Bowes, Paul Gibson, Sarah McKillop, Roona Sinha, Lillian Sung, Catherine Vezina, Laura Wheaton, Alexandra P. Zorzi, Marie‐Claude Pelland‐Marcotte, Thai Hoa Tran   +21 more
wiley   +1 more source

Developing a quality indicator system for pediatric clinical trials management of research centers in China: a modified Delphi-Analytic Hierarchy Process study

BMC Pediatrics
Background Pediatric clinical trials face many challenges that hinder the development of safe and effective pediatric drugs. Enhancing risk control and management quality of pediatric clinical trials in research centers is essential to address these ...
Chang Liu, Yi Liu, Bo Xuan, Yuenan Qi, Ling Ou, Jianmin Zhang   +5 more
doaj   +1 more source

The impact of clinical trial units on the value of clinical research in Switzerland

Swiss Medical Weekly, 2018
A prominent 2014 series by The Lancet on “Increasing value, reducing waste in biomedical research” provided recommendations on how to optimise precious resources, including in clinical research.
Belinda von Niederhäusern, Annette Magnin, Christiane Pauli-Magnus   +2 more
doaj   +1 more source

Impact of Initial Treatment Setting on Survival in Relapsed Pediatric and AYA Bone Sarcomas: A Secondary Analysis of a Prospective Clinical Trial

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Outcomes in relapsed or refractory pediatric and AYA bone sarcomas remain poor, and the impact of early referral to specialized sarcoma centers on survival is unclear. Early centralization of care may improve local and systemic treatment quality, but evidence in this population is limited.
Justyna Antoniuk‐Majchrzak, Katarzyna Bilska, Tomasz Koziński, Jadwiga Węcławek‐Tompol, Dorota Sega‐Pondel, Radosław Chaber, Wanda Badowska, Katarzyna Rosłan, Hanna Koseła‐Paterczyk, Anna Raciborska   +9 more
wiley   +1 more source

Asian clinical trial trends by type of sponsor, trial phase, disease area and country

, 2011
Summary Asian trials are predominantly industry-sponsored phase III trials - 33.8% of all such trials registered are conducted in Asia. About half of the top 30 sponsors have an Asian arm for 25% or more of their phase II trials, and about half of the ...
Karlberg, JPE
core  

Marketing and clinical trials : a case study [PDF]

, 2007
Background: Publicly funded clinical trials require a substantial commitment of time and money. To ensure that sufficient numbers of patients are recruited it is essential that they address important questions in a rigorous manner and are managed well ...
Francis, D, Francis, David, McDonald, Alison Mary, Knight, R.C, McDonald, A.M, Garcia Jo, McDonald Alison M, Francis, David; id_orcid, McDonald, Alison M, Vikki A Entwistle, Campbell, Marion K, Rosemary C Knight, Snowdon Claire, Entwistle, V.A, Campbell, Marion K., Francis David, Grant Adrian M, Knight, Rosemary C, Haleema Shakur, Entwistle Vikki A, Roberts, Ian, Entwistle, Vikki A., Elbourne, D.R, Shakur, H, Entwistle, Vikki, Mcdonald, Alison M., Campbell, Marion Kay, Snowdon, Claire, Grant, Adrian M, Garcia, J, David Francis, Diana R Elbourne, Alison M McDonald, Elbourne, Diana R., Roberts Ian, Shakur, Haleema, Elbourne, Diana R, Grant, Adrian Maxwell, Campbell Marion K, Entwistle, Vikki A, Snowdon, C, Campbell, M.K, Shakur Haleema, Grant, Adrian M., Knight, Rosemary C., Garcia, Jo, Adrian M Grant, Ian Roberts, Claire Snowdon, Grant, A.M, Marion K Campbell, Knight Rosemary C, Jo Garcia, Elbourne Diana R, Roberts, I   +54 more
core   +4 more sources