Results 101 to 110 of about 2,211,903 (315)

Conditionally unbiased estimation in phase II/III clinical trials with early stopping for futility [PDF]

, 2013
Seamless phase II/III clinical trials combine traditional phases II and III into a single trial that is conducted in two stages, with stage 1 used to answer phase II objectives such as treatment selection and stage 2 used for the confirmatory analysis ...
Todd, Susan C., Susan Todd, Todd, Susan, Peter K. Kimani, Stallard, Nigel, Nigel Stallard, Kimani, Peter K.   +6 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Pharmacokinetics and Safety of HRS-1780 in Renal Impaired Subjects: A Multicenter, Non-Randomized, Open-Label Study

Drug Design, Development and Therapy
Yue Fei,1 Zhihong Xie,2 Yuanyuan Luo,3 Xiaolan Yong,4 Na Li,1 Rong Huang,1 Xiaolin Du,4 Yijing Zhu,4 Dongmei Lan,3 Yang Qi,3 Gang Cheng,1 Quanren Wang,1 Kai Shen1 1Department of Clinical Research, Jiangsu Hengrui Pharmaceuticals, Shanghai, People’s ...
Fei Y, Xie Z, Luo Y, Yong X, Li N, Huang R, Du X, Zhu Y, Lan D, Qi Y, Cheng G, Wang Q, Shen K   +12 more
doaj  

REVAMP Clinical Trial Dataset

Data are derived from the Resistance Testing for Management of HIV Virologic Failure in Sub-Saharan Africa (REVAMP) clinical trial. The de-identified dataset includes include randomization allocation, baseline participant characteristics and primary and ...
Siedner. Mark
core   +1 more source

Establishing consistency across all regions in a multi-regional clinical trial

, 2012
[[abstract]]In recent years, global collaboration has become a conventional strategy for new drug development. To accelerate the development process and shorten approval time, the design of multi-regional clinical trials (MRCTs) incorporates subjects ...
Tsou, HH;James Hung, HM;Chen, YM;Huang, WS;Chang, WJ;Hsiao, CF
core   +1 more source

Ethical and scientific considerations for patient enrollment into concurrent clinical trials. [PDF]

, 2014
Researchers and institutional review boards often consider it inappropriate for patients to be asked to consent to more than one study despite there being no regulatory prohibition on co-enrollment in most countries.
Williamson, Elizabeth, Oakley, Justin, Justin Oakley, Andrew Forbes, Myles, Paul S, Elizabeth Williamson, Forbes, Andrew, Paul S Myles   +7 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Pharmacokinetics and Safety of HRS-1780 in Renal Impaired Subjects: A Multicenter, Non-Randomized, Open-Label Study [Corrigendum]

Drug Design, Development and Therapy
Fei Y, Xie Z, Luo Y, et al. Drug Des Devel Ther. 2025;19:3751–3761. Page 3760, first line, the text “Our current study had similar findings” should read “Our study observed an increase in the exposure to HRS ...
Fei Y, Xie Z, Luo Y, Yong X, Li N, Huang R, Du X, Zhu Y, Lan D, Qi Y, Cheng G, Wang Q, Shen K   +12 more
doaj  

Comparative studies of 2168 plasma proteins measured by two affinity-based platforms in 4000 Chinese adults

Nature Communications
Proteomics offers unique insights into human biology and drug development, but few studies have directly compared the utility of different proteomics platforms.
Baihan Wang, Alfred Pozarickij, Mohsen Mazidi, Neil Wright, Pang Yao, Saredo Said, Andri Iona, Christiana Kartsonaki, Hannah Fry, Kuang Lin, Yiping Chen, Huaidong Du, Daniel Avery, Dan Schmidt-Valle, Canqing Yu, Dianjianyi Sun, Jun Lv, Michael Hill, Liming Li, Derrick A. Bennett, Rory Collins, Robin G. Walters, Robert Clarke, Iona Y. Millwood, Zhengming Chen, On behalf of China Kadoorie Biobank Collaborative Group   +25 more
doaj   +1 more source

On Clinical Trials

Optometry and Vision Science, 2021
Lisa A, Jones Jordan, Michael D, Twa
openaire   +3 more sources