Results 111 to 120 of about 9,816,425 (315)

The Dermal Echo-Void (DEV) Index: A Reproducible Computer-Assisted High-Frequency Ultrasound Measure of Superficial-Dermis Structure Beyond Skin Density

Cosmetics
Background: High-frequency ultrasound (HFUS) quantifies dermal skin density well, yet the low-echogenic (hypoechoic) regions in the image have not been treated as having informative value.
Youngrin Kwag, Seok Hwan Oh, HuiJeong Jeong, YooRi Kang, Min Sook Jung, Hongseok Kim, Wonkyu Hong   +6 more
doaj   +1 more source

Clinical trials on trial [PDF]

European Journal of Hospital Pharmacy, 2012
It has been 3 years since I wrote an editorial on the topic of uncertainty around new cancer treatments (issue 4 of volume 2009). Has this field progressed in 3 years? I think the answer is both yes and no. Yes because we now have a clearer picture of why cancer drugs can sometimes act differently (usually worse) in real life situations than they seem ...
openaire   +2 more sources

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

Reducing the environmental impact of trials: a comparison of the carbon footprint of the CRASH-1 and CRASH-2 clinical trials. [PDF]

, 2011
BACKGROUND: All sectors of the economy, including the health research sector, must reduce their carbon emissions. The UK National Institute for Health Research has recently prepared guidelines on how to minimize the carbon footprint of research.
Subaiya, Saleena, Hogg, Euan, Ian Roberts, Saleena Subaiya, Roberts Ian, Euan Hogg, Hogg Euan, Subaiya Saleena, Roberts, Ian   +8 more
core   +2 more sources

A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Highly Selective NaV1.8 Inhibitor JKN2306 in Healthy Chinese Subjects

Pharmacology Research & Perspectives
JKN2306 is a novel, highly selective Nav1.8 inhibitor under development for the treatment of acute pain. This first‐in‐human study aimed to evaluate its safety, tolerability, pharmacokinetics, and food effect (FE).
Ying Yang, Mai Han, Gang Cui, Dan Zhang, Wei Wu, Na Mi, Jiangli Jin, Shuxiao Zhang, Xin Zhang, Junjie Li, Chunyan Xiao, Jing Wang, Chaoyun Gou, Chong Su, Jintong Li   +14 more
doaj   +1 more source

Pharmacokinetics and safety comparison of cycloserine capsules and their generic counterpart: a randomized, open-label, two-period, two-sequence, single-dose crossover bioequivalence study in healthy Chinese subjects

Frontiers in Pharmacology
IntroductionCycloserine is a broad‐spectrum antibiotic and clinically important second‐line anti‐tuberculosis agent. This study assessed the bioequivalence of a test cycloserine formulation versus its reference formulation under fasted and fed conditions.
Xiuqing Peng, Liying Zhang, Caiyun Jia, Congyang Ding, Haojing Song, Zhanjun Dong, Huizhen Wu, Wanjun Bai   +7 more
doaj   +1 more source

The Impact of Tenapanor on Body Composition and Blood Pressure in Peritoneal Dialysis Patients: A Pilot Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Instruction Tenapanor potentially affects fluid volume and blood pressure. This study explored its effects on these parameters in patients undergoing peritoneal dialysis (PD). Methods We conducted a single‐arm, prospective observational study that enrolled 10 patients on PD with hyperphosphatemia who were newly initiated on tenapanor.
Shun Yoshida, Kengo Asahina, Keiichi Osano, Natsumi Saegusa, Kohei Yamamura, Kie Ohkoshi, Miho Shikata, Toshihisa Ishii, Makiko Konishi, Kazuya Takahashi, Kohei Uchimura, Ayumu Nakashima   +11 more
wiley   +1 more source

Cognitive behavioural therapy versus supportive therapy for persistent positive symptoms in psychotic disorders: the POSITIVE Study, a multicenter, prospective, single-blind, randomised controlled clinical trial [PDF]

, 2010
Background: It has been demonstrated that cognitive behavioural therapy (CBT) has a moderate effect on symptom reduction and on general well being of patients suffering from psychosis.
Andreas Bechdolf, Wölwer, Wolfgang, Buchkremer Gerhard, Klingberg, Stefan, Tilo Kircher, Bernhard W Müller, Engel Corinna, Bechdolf Andreas, Klingberg Stefan, Wagner Michael, Engel, Corinna, Buchkremer, Gerhard, Corinna Engel, Wittorf, Andreas, Meisner Christoph, Christoph Meisner, Sartory, Gudrun, Wiedemann, Georg, Michael Wagner, Müller, Bernhard W., Sartory Gudrun, Wagner, Michael, Meisner, Christoph, Stefan Klingberg, Georg Wiedemann, Wiedemann Georg, Herrlich Jutta, Wittorf Andreas, Jutta Herrlich, König Hans-Helmut, Herrlich, Jutta, Andreas Wittorf, Wolfgang Wölwer, König, Hans-Helmut, Bechdolf, Andreas, Kircher Tilo, Wölwer Wolfgang, Kircher, Tilo, Hans-Helmut König, Gerhard Buchkremer, Gudrun Sartory, Müller Bernhard W   +41 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

UK back pain exercise and manipulation (UK BEAM) trial - national randomised trial of physical treatments for back pain in primary care: objectives, design and interventions [PDF]

, 2003
Low back pain has major health and social implications. Although there have been many randomised controlled trials of manipulation and exercise for the management of low back pain, the role of these two treatments in its routine management remains ...
null null, UK Beam (Back pain Exercise and Manipulation) Trial Team, Burton, A. Kim   +2 more
core   +2 more sources