Results 91 to 100 of about 9,816,425 (315)

Pharmacokinetics, Relative Bioavailability, and Safety of the SHR0302 Oral Solution and Tablets: A Single-Center, Randomized, Open-Label, Crossover (Two-Formulation, Two-Period) Phase I Trial in Healthy Chinese Volunteers

Drug Design, Development and Therapy
Xin Gao,1 Kai Shen,2 Dan Tang,2 Wenjing Bai,1 Juan Wang,1 Tingting Wang,1 Xin Wang1 1Clinical Trial Center, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Key Laboratory of ...
Gao X, Shen K, Tang D, Bai W, Wang J, Wang T, Wang X   +6 more
doaj  

Feeding, Fear, and Acceptance: Caregivers’ Experiences of Nutritional Support During Childhood Cancer Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose To explore caregivers' experiences and perceptions of the nutritional challenges faced by children and adolescents undergoing cancer treatment, including oral intake and the use of nutritional support. Methods This was a qualitative study based on focus groups with parents and caregivers at a Brazilian pediatric oncology hospital ...
Danyelle Apparecida Balsamão Marques, Mariana dos Santos Murra, Welinton Hirai, Ana Laura Balduino do Nascimento, Karla Emilia de Sá Rodrigues, Wilson Elias de Oliveira Junior   +5 more
wiley   +1 more source

Pharmacokinetics and Safety of Oxycodone/Naloxone Prolonged-Release Tablets in Chinese Patients with Chronic Pain

Drug Design, Development and Therapy
Yongji He,1,2,* Ling Yang,1,2,* Qianqian Mou,1,2 Xiaotao Cao,1,2 Xiaohong Zhu,1,2 Ying Wang,1,2 Zhu Luo1,2 1Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Clinical Trial Center ...
He Y, Yang L, Mou Q, Cao X, Zhu X, Wang Y, Luo Z   +6 more
doaj  

Neurocognitive, School‐Based, and Quality of Life Outcomes for Youth With Sickle Cell Disease and Thalassemia: A Scoping Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT The medical burdens of sickle cell disease (SCD) and transfusion‐dependent β‐thalassemia (TDT) are chronic and cumulative, even in children. Yet the effects expand beyond medications and healthcare visits due to their impacts on school attendance, academic performance, and peer engagement.
Mary Ann Etling, Hakim Tokhi, Alexander A. Boucher   +2 more
wiley   +1 more source

In the era of systematic reviews, does the size of an individual trial still matter. [PDF]

, 2008
Systematic reviews that combine high-quality evidence from several trials are now widely considered to be at the top of the hierarchy of clinical evidence.
Gordon H Guyatt, Edward J Mills, Elbourne Diana, Diana Elbourne, Mills, Edward J, Mills Edward J, Elbourne, Diana, Guyatt Gordon H, Guyatt, Gordon H   +8 more
core   +2 more sources

Pharmacokinetics and Bioequivalence of Mycophenolate Sodium Enteric-Coated Tablets Under Fasting and Fed Conditions: A Single-Dose, Open-Label, Four-Period Replicated Crossover Study in Healthy Chinese Male Subjects

Drug Design, Development and Therapy
Peiwen Zhang,1,* Mupeng Li,1,* Hao Jiang,2 Fangfang Liu,1 Qian Huang,1 Yangyun Han,1 Lianlian Fan1 1Phase 1 Clinical Trial Center, Deyang People′s Hospital, Deyang, Sichuan, People’s Republic of China; 2Zhejiang Meidishen Biomedical Co ...
Zhang P, Li M, Jiang H, Liu F, Huang Q, Han Y, Fan L   +6 more
doaj  

Representation of Sickle Cell Disease Patients in Pediatric and Adult Care: What We Discovered Using Informatics for Integrating Biology and the Bedside (i2b2) Data

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Transitioning from pediatric to adult care is a high‐risk period for individuals with sickle cell disease (SCD). An initial observation at one academic medical center suggested a sex‐based disparity in clinic populations, prompting a national investigation.
Laurie J. Duckworth, Kholod Alhassan, Ada De La Osa, John Stephen, Yue Yao, Diana J. Wilkie   +5 more
wiley   +1 more source

The added value of ordinal analysis in clinical trials: an example in traumatic brain injury. [PDF]

, 2011
INTRODUCTION: In clinical trials, ordinal outcome measures are often dichotomized into two categories. In traumatic brain injury (TBI) the 5-point Glasgow outcome scale (GOS) is collapsed into unfavourable versus favourable outcome.
Perel, P, Steyerberg, Ewout W, IMPACT (International Mission on Prognosis and Clinical Trial De, Edwards, P. (Phil), Steyerberg, Ewout, Ewout W Steyerberg, Phil Edwards, Perel, P. (Pablo), Lingsma, Hester F., Murray, G.D. (Gordon), Steyerberg, Ewout W., Roozenbeek, Bob, Lingsma, Hester F, Gordon D Murray, Andrew IR Maas, Edwards, P, Maas, AIR (Arne), Roberts, I. (Ian), CRASH (Corticosteroid Randomisation After Significant Head Injur, Roberts, Ian, Perel, Pablo, Murray, Gordon D, Maas, A.I.R. (Andrew), ?, ?, Ian Roberts, Maas, Andrew Ir, null null, Edwards, Phil, Steyerberg, E.W. (Ewout), Hester F Lingsma, Murray, Gordon D., Pablo Perel, Roozenbeek, B. (Bob), Murray, GD, Bob Roozenbeek, Maas, Andrew I.R., Lingsma, Hester, Roberts, I   +37 more
core   +1 more source

Clinical trial evaluation: the EDOSURE clinical trial program [PDF]

Future Cardiology
EDOSURE is a trial program of the direct oral anticoagulant drug edoxaban, comprising ten randomized clinical trials of which eight are currently published. They evaluate the use of edoxaban in the treatment of nonvalvular atrial fibrillation and acute venous thromboembolism, including in special circumstances such as patients undergoing cardiac ...
Michael Griffin, Gregory YH Lip
openaire   +2 more sources

Lorlatinib‐Containing Therapy for MYCN‐Amplified, ALK‐Mutated Neuroblastoma With Bulky Leptomeningeal Relapse: A Case Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Central nervous system (CNS) relapse of neuroblastoma carries a poor prognosis, and craniospinal irradiation (CSI) poses substantial long‐term toxicity in young children. We report a toddler with MYCN‐amplified neuroblastoma harboring somatic ALK R1275Q who developed extensive leptomeningeal relapse with paraplegia.
Jinwoo Kim, Minji Kim, Nani Jung, Sung Eun Kim, Ji Yoon Kim, Mi Ae Chu, Jung Eun Kwon, Yeo Hyang Kim, So Mi Lee, Ki‐Su Park, Jeong Eun Lee, Ye Jee Shim   +11 more
wiley   +1 more source