Results 61 to 70 of about 81,239 (301)

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Importance of the Androgen Receptor Signaling in Gene Transactivation and Transrepression for Pubertal Maturation of the Testis

Cells, 2019
Androgens are key for pubertal development of the mammalian testis, a phenomenon that is tightly linked to Sertoli cell maturation. In this review, we discuss how androgen signaling affects Sertoli cell function and morphology by concomitantly inhibiting
Nadia Y. Edelsztein, Rodolfo A. Rey
doaj   +1 more source

Use of Antiandrogens as Therapeutic Agents in COVID-19 Patients

Viruses, 2022
COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), is estimated to have caused over 6.5 million deaths worldwide. The emergence of fast-evolving SARS-CoV-2 variants of concern alongside increased transmissibility and/or
Efstathios S. Giotis, Emine Cil, Greg N. Brooke   +2 more
doaj   +1 more source

Abiraterone acetate treatment lowers 11-oxygenated androgens

, 2020
CONTEXT: The human adrenal is the dominant source of androgens in castration-resistant prostate cancer (CRPC) and classic 21-hydroxylase deficiency (21OHD).
Auchus, Richard J., Alyamani, Mohammed, Wright, Connor, Sharifi, Nima, O'Day, Patrick   +4 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Simultaneous profiling of classic and 11-oxygenated androgens via a novel derivatization method coupled with HPLC-MS/MS: A game-changer for endocrine disorders

Talanta Open
The accumulation of classic or 11-oxygenated androgens is a hallmark of polycystic ovary syndrome (PCOS). Traditional electrochemiluminescence immunoassays (ECLIA) are limited in their ability to measure a broad spectrum of androgens and may suffer from ...
Xianhua Zhang, Huiyu Xu, Yue Sun, Xin Xiong, Lingling Liu, Li Yang, Libo Zhao, Xiaona Li, Rong Li, Rongsheng Zhao   +9 more
doaj   +1 more source

Androgens and Erythropoiesis: A Review.

, 2009
Association between androgens and erythropoiesis has been known for more than seven decades. Androgens stimulate hematopoietic system by various mechanisms.
MAGGIO, Marcello Giuseppe, BASARIA S., SHAHANI S, BRAGA BASARIA M   +3 more
core   +1 more source

Androgens in pregnancy:roles in parturition [PDF]

, 2014
BACKGROUND Understanding the physiology of pregnancy enables effective management of pregnancy complications that could otherwise be life threatening for both mother and fetus.
Makieva, Sofia, Norman, Jane E, Saunders, Philippa T K, Saunders, Philippa T K; id_orcid   +3 more
core   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Androgens added to immunosuppressive regimen in patients with aplastic anaemia. A retrospective study

Revista Médica del Hospital General de México, 2015
Background: Androgens have been used to treat bone marrow failure syndromes such as aplastic anaemia (AA) since the 1970s, and are currently used as adjuvants to other treatment regimens.
C.O. Ramos-Peñafiel, V.E. Ferrer-Argote, R. Trejo-Ayala, G. León-González, A. Santoyo-Sánchez, J. Collazo-Jaloma   +5 more
doaj   +1 more source