Results 41 to 50 of about 61,244 (265)

Androgens and cardiac diseases

Monaldi Archives for Chest Disease, 2013
Although androgens have been considered deleterious for the cardiovascular system, recent data have demonstrated favourable testosterone effects on cardiac and vascular remodeling and clinical outcome.
Vittorio Bianchi, Alessandro Mezzani
doaj   +1 more source

Insights into Androgen Receptor Action in Lung Cancer

Endocrines, 2023
Sex hormones and their receptors play a crucial role in human sexual dimorphism and have been traditionally associated with hormone-dependent cancers like breast, prostate, and endometrial cancer.
Darko Durovski, Milica Jankovic, Stefan Prekovic   +2 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

A Small Peptide Targeting the Ligand-Induced Androgen Receptor/Filamin a Interaction Inhibits the Invasive Phenotype of Prostate Cancer Cells

Cells, 2021
Prostate cancer (PC) is one of the most widespread malignancies among males worldwide. The androgen receptor (AR) plays a major role in prostate cancer development and progression and is the main target of PC therapy.
Marzia Di Donato, Pia Giovannelli, Maria Vittoria Barone, Ferdinando Auricchio, Gabriella Castoria, Antimo Migliaccio   +5 more
doaj   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

The multiple actions of testosterone in men: nature knows best

Asian Journal of Andrology, 2014
In male hormone replacement therapy Finkelstein et al. show that testosterone rather than synthetic "pure" androgens should be prescribed. Testosterone is converted to the superactive androgen dihydrotestosterone and to estradiol, and thus has actions ...
John W Funder
doaj   +1 more source

Gender Differences in the Pathogenesis and Risk Factors of Hepatocellular Carcinoma

Biology, 2023
Several chronic liver diseases are characterized by a clear gender disparity. Among them, hepatocellular carcinoma (HCC) shows significantly higher incidence rates in men than in women. The different epidemiological distribution of risk factors for liver
Riccardo Nevola, Giovanni Tortorella, Valerio Rosato, Luca Rinaldi, Simona Imbriani, Pasquale Perillo, Davide Mastrocinque, Marco La Montagna, Antonio Russo, Giovanni Di Lorenzo, Maria Alfano, Maria Rocco, Carmen Ricozzi, Klodian Gjeloshi, Ferdinando Carlo Sasso, Raffaele Marfella, Aldo Marrone, Loreta Anesti Kondili, Nicolino Esposito, Ernesto Claar, Domenico Cozzolino   +20 more
doaj   +1 more source

A Fully Human Engineered Bone Niche With Endogenous Osteoclastogenesis Reveals Osteoclast‐Dependent Osteomimicry in Prostate Cancer Cells

Advanced Healthcare Materials, EarlyView.
A human 3D bone niche integrating osteoblasts and osteoclasts enables co‐culture with prostate cancer cell lines and patient‐derived organoids. The engineered niche (i) models aspects of reciprocal phenotypic regulation between osteoblasts and cancer cells, (ii) captures osteoclast‐enhanced osteomimicry in tumor cells, and (iii) establishes a ...
Andrea Mazzoleni, Robin Dolgos, Thomas Menter, Boris Dasen, Arnaud Scherberich, Clémentine Le Magnen, Manuele G. Muraro, Ivan Martin   +7 more
wiley   +1 more source

Importance of the Androgen Receptor Signaling in Gene Transactivation and Transrepression for Pubertal Maturation of the Testis

Cells, 2019
Androgens are key for pubertal development of the mammalian testis, a phenomenon that is tightly linked to Sertoli cell maturation. In this review, we discuss how androgen signaling affects Sertoli cell function and morphology by concomitantly inhibiting
Nadia Y. Edelsztein, Rodolfo A. Rey
doaj   +1 more source

Use of Antiandrogens as Therapeutic Agents in COVID-19 Patients

Viruses, 2022
COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), is estimated to have caused over 6.5 million deaths worldwide. The emergence of fast-evolving SARS-CoV-2 variants of concern alongside increased transmissibility and/or
Efstathios S. Giotis, Emine Cil, Greg N. Brooke   +2 more
doaj   +1 more source