Results 41 to 50 of about 141,437 (356)

A STUDY OF THE ANDROGENIC ACTIVITY OF ANTI-ANDROGEN

Folia Endocrinologica Japonica, 1990
To investigate the androgenic activity of steroidal and nonsteroidal anti-androgens, the effect of several compounds on some parameters as an androgenic activity was measured in the ventral prostate (VP) and seminal vesicle gland (SV) of castrated male rats.
Yamanaka, Hidetoshi, Imai, Kyoichi, Watanabe, Keiko, Takahashi, Osamu, Shimizu, Nobuaki, Kawashima, Kiyotaka, Nakata, Seiji, Suzuki, Takanori   +7 more
openaire   +3 more sources

Abiraterone acetate treatment lowers 11-oxygenated androgens

, 2020
CONTEXT: The human adrenal is the dominant source of androgens in castration-resistant prostate cancer (CRPC) and classic 21-hydroxylase deficiency (21OHD).
Auchus, Richard J., Alyamani, Mohammed, Wright, Connor, Sharifi, Nima, O'Day, Patrick   +4 more
core   +1 more source

Differential regulation of clusterin and its isoforms by androgens in prostate cells [PDF]

, 2007
Clusterin mRNA levels were shown to increase dramatically in rat ventral prostate following castration, and clusterin was therefore originally thought to be repressed by androgens.
Zhou Wang, Gleave, Martin, Dawn R. Cochrane, Wang, Zhou, Cochrane, Dawn, Muramaki, Motosugu, Colleen C. Nelson, Martin E. Gleave, Nelson, Colleen, Motosugu Muramaki   +9 more
core   +1 more source

Androgen Receptor and Mechanism of Androgen Action

Annals of Medicine, 1993
Androgen receptor is the intracellular protein that mediates biological actions of physiological androgens (testosterone and 5 alpha-dihydrotestosterone). Androgen receptor belongs to a large family of ligand-dependent proteins whose function is to modulate expression of genes and gene networks in a cell- and tissue-specific manner.
O A, Jänne, J J, Palvimo, P, Kallio, M, Mehto   +3 more
openaire   +2 more sources

Manipulating Androgens for Therapy

, 2013
Androgens are important during all stages of development from fetal life to adulthood. There are many clinical situations in which manipulation of androgens may be required.
McEwan, Iain J, Smith, Lee B, Lee B. Smith, Iain J. McEwan   +3 more
core   +1 more source

Serum levels of androgens in acne & their role in acne severity [PDF]

, 2019
Objectives: To correlate acne severity with elevated androgen levels and to compare androgen levels between cases and controls. Methods: This case-control study was carried out in the Department of Dermatology, Mayo Hospital, Lahore from March 2016 ...
Iftikhar, Usma, Choudhry, Nakshab
core   +1 more source

Neurology of Androgens and Androgenic Supplements

Current Neurology and Neuroscience Reports
Abstract Purpose of Review This article explores the intricate relationship between androgens, androgen receptors, and the central nervous system. We examine the role of physiologically derived androgens and androgenic supplements in neurodevelopment and neuroplasticity and delve into the involvement of androgen ...
Dengri, Chetna, Mayberry, Whitney, Koriesh, Ahmed, Nouh, Amre   +3 more
openaire   +2 more sources

Role of androgens, progestins and tibolone in the treatment of menopausal symptoms: a review of the clinical evidence

, 2008
Maria Garefalakis, Martha HickeySchool of Women’s and Infants’ Health, The University of Western Australia, King Edward Memorial Hospital, Subiaco, Western Australia, AustraliaAbstract: Estrogen-containing hormone therapy (HT) is the most ...
Maria Garefalakis, Hickey, M, Martha Hickey, Garefalakis, M   +3 more
core   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source