Results 51 to 60 of about 141,437 (356)

Androgens and Erythropoiesis: A Review.

, 2009
Association between androgens and erythropoiesis has been known for more than seven decades. Androgens stimulate hematopoietic system by various mechanisms.
MAGGIO, Marcello Giuseppe, BASARIA S., SHAHANI S, BRAGA BASARIA M   +3 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Anti‐androgens may protect against severe COVID‐19 outcomes: results from a prospective cohort study of 77 hospitalized men [PDF]

, 2020
The COVID‐19 pandemic has disproportionally affected men. 1 Men infected with SARS‐CoV‐2 are more than twice as likely to be admitted to the intensive care unit (ICU).
J. McCoy, Kovacevic, Maja, S. Serrano‐Villar, F.A. Cadegiani, R. Sinclair, A. Goren, P.M. Ramos, Cadegiani, F. A., Ron, Raquel, Ron, R., Goren, A., Wambier, Carlos Gustavo, Comeche, B., S. Vaño‐Galván, Shapiro, J., J. Shapiro, Herrera, S., Goren, Andy, Ramos, P. M. [UNESP], Vano-Galvan, S., Herrera, Sabina, McCoy, J., Kovacevic, M., McCoy, John, A. Tosti, Comeche, Belen, Shapiro, Jerry, Gioia, F., S. Herrera, Gioia, Francesca, Serrano‐Villar, Sergio, F. Gioia, R. Ron, M. Kovacevic, C.G. Wambier, B. Comeche, Ramos, Paulo Müller, Tosti, Antonella, Sinclair, R., Serrano-Villar, S., Cadegiani, Flávio Adsuara, Wambier, C. G., Vaño‐Galván, Sergio, Sinclair, Rodney, Tosti, A.   +44 more
core   +1 more source

Androgens and COVID-19 [PDF]

, 2022
Background The humans have been disproportionately affected by the coronavirus disease (COVID-19) pandemic. The novel coronavirus or the severe acute respiratory syndrome coronavirus 2 (SARS-COV2) causing coronavirus disease (COVID-19) has spread across
Goren, Andy, Cockerell, Clay J., Patil, Anant, Das, Kinnor, Goldust, Mohamad   +4 more
core   +1 more source

Androgens and Alzheimerʼs disease

, 2009
Purpose of review: To discuss the relationship between androgens, cognition and Alzheimer's disease. Recent findings: It has been found that low circulating levels of androgens are a risk factor for Alzheimer's disease.
Harvey, A.R., Ralph N Martins, Eleanor S Drummond, Drummond, E.S., Alan R Harvey, Martins, R.N.   +5 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications [PDF]

, 2017
The principle steroidal androgens are testosterone and its metabolite 5α-dihydrotestosterone (DHT), which is converted from testosterone by the enzyme 5α-reductase.
Angela K. Lucas-Herald, Rheure Alves-Lopes, Augusto C. Montezano, S. Faisal Ahmed, Rhian M. Touyz, Ahmed, S. Faisal, Touyz, Rhian M., Alves-Lopes, Rheure, Lucas-Herald, Angela K., Montezano, Augusto C.   +9 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Low Perinatal Androgens Predict Recalled Childhood Gender Nonconformity in Men

, 2022
This is the data and code for the forthcoming paper titled "Low Perinatal Androgens Predict Recalled Childhood Gender Nonconformity in Men.
Talia Shirazi
core   +1 more source