Results 1 to 10 of about 340 (113)

The essential differences in microbial and chemical components of musk of different qualities secreted by captive male forest musk deer (Moschus berezovskii). [PDF]

Microb Biotechnol, 2022
Next‐generation sequencing and gas chromatography‐mass spectrometry were used to explore the essential differences between different quality of musk in microbial and chemical compositions. The results indicate that 14 taxa at the genus level and six compounds were identified to specifically distinguish DM and MM groups under the LEfSe analysis and OPLS‐
Wang Y, Sun M, Chang F, Wang J, Wang Y, Tang J, Zhang K, Gao L, Xue X, Wan Y.   +9 more
europepmc   +2 more sources

PMON251 Loss of Constitutive Androstane Receptor, CAR reduces the serum androgens levels and alters reproductive function

Journal of the Endocrine Society, 2022
The nuclear receptor, Constitutive Androstane Receptor (CAR/NR1i3) is extensively known for its detoxification function in the liver. We have identified the role of CAR in regulating androgen levels and regulating testis function.
Anjana Asokakumar, J. P. Hernandez, Rui Xiao, D. Moore, S. Anakk   +4 more
semanticscholar   +1 more source

Biomarker Records of Environmental Shifts on the Labrador Shelf During the Holocene

Paleoceanography and Paleoclimatology, Volume 38, Issue 9, September 2023., 2023
Abstract The ultimate demise of the Laurentide Ice Sheet (LIS) and the preceding and succeeding oceanographic changes along the western Labrador Sea offer insights critically important to improve climate predictions of expected future climate warming and further melting of the Greenland ice cap.
Henriette Kolling, Ralph Schneider, Felix Gross, Christian Hamann, Markus Kienast, Stephanie Kienast, Kristin Doering, Kirsten Fahl, Ruediger Stein   +8 more
wiley   +1 more source

Holocene variability in sea‐ice conditions in the eastern Baffin Bay‐Labrador Sea – A north–south biomarker transect study

Boreas, Volume 51, Issue 3, Page 553-572, July 2022., 2022
Reconstructions of sea‐surface conditions during the Holocene were achieved using three sediment cores from northeastern Baffin Bay (GeoB19948‐3 and GeoB19927‐3) and the Labrador Sea (GeoB19905‐1) along a north–south transect based on sea‐ice IP25 and open‐water phytoplankton biomarkers (brassicasterol, dinosterol and HBI III).
Jeetendra Saini, Ruediger Stein, Kirsten Fahl, Jens Weiser, Dierk Hebbeln, Lina Madaj   +5 more
wiley   +1 more source

Deletion of Nuclear Receptor Constitutive Androstane Receptor CAR Increases Anxiety and Lowers Androgen Levels

Journal of the Endocrine Society, 2021
The orphan nuclear receptor, Constitutive Androstane Receptor (CAR, NR1I3) is primarily known to regulate the transcriptional networks involved in detoxification.
J. P. Hernandez, Anjana Asokakumar, Rui Xiao, David D Moore, S. Anakk   +4 more
semanticscholar   +1 more source

Holocene Interactions Between Glacier Retreat, Sea Ice Formation, and Atlantic Water Advection at the Inner Northeast Greenland Continental Shelf

Paleoceanography and Paleoclimatology, Volume 35, Issue 11, November 2020., 2020
Abstract During the past four decades significant decrease in Arctic sea ice and a dramatic ice mass loss of the Greenland Ice Sheet (GIS) has been coincident with global warming and an increase in atmospheric CO2. In Northeast Greenland significant mass loss from the outlet glaciers Nioghalvfjerdsbræ (79NG) and Zachariæ Isstrøm (ZI) and intensive ...
Nicole Syring, Jeremy M. Lloyd, Ruediger Stein, Kirsten Fahl, Dave H. Roberts, Louise Callard, Colm O'Cofaigh   +6 more
wiley   +1 more source

Biomarker Distributions in (Sub)‐Arctic Surface Sediments and Their Potential for Sea Ice Reconstructions

Geochemistry, Geophysics, Geosystems, Volume 21, Issue 10, October 2020., 2020
Abstract To evaluate the present sea ice changes in a longer‐term perspective, the knowledge of sea ice variability on preindustrial and geological time scales is essential. For the interpretation of proxy reconstructions it is necessary to understand the recent signals of different sea ice proxies from various regions.
Henriette M. Kolling, Ruediger Stein, Kirsten Fahl, Henrik Sadatzki, Anne de Vernal, Xiaotong Xiao   +5 more
wiley   +1 more source

Detecting the misuse of 7‐oxo‐DHEA by means of carbon isotope ratio mass spectrometry in doping control analysis

Rapid Communications in Mass Spectrometry, Volume 34, Issue 12, 30 June 2020., 2020
Rationale The misuse of 7‐oxo‐DHEA (3β‐hydroxyandrost‐5‐ene‐7,17‐dione) is prohibited according to the World Anti‐Doping Agency (WADA) code. Nevertheless, it is easily available as a dietary supplement and from black market sources. In two recent doping control samples, significant amounts of its main metabolite 7β‐OH‐DHEA were identified ...
Thomas Piper, Gregor Fusshöller, Hans Geyer, Ani Toboc, Mădălin‐George Dănilă, Mario Thevis   +5 more
wiley   +1 more source

Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands*

Journal of Biological Chemistry, 2000
Xenobiotics induce the transcription of cytochromes P450 (CYPs) 2B and 3A through the constitutive androstane receptor (CAR; NR1I3) and pregnane X receptor (PXR; NR1I2), respectively.
L. Moore, D. Parks, Stacey A. Jones, R. Bledsoe, T. Consler, J. Stimmel, B. Goodwin, C. Liddle, S. Blanchard, T. Willson, J. Collins, S. Kliewer   +11 more
semanticscholar   +1 more source

Transcriptional Regulation of CYP2C9 Gene

Journal of Biological Chemistry, 2002
Although cytochrome P450 2C9 (CYP2C9) is a major CYP expressed in the adult human liver, its mechanism of regulation is poorly known. In previous work, we have shown that CYP2C9is inducible in primary human hepatocytes by xenobiotics including ...
S. Gerbal-Chaloin, M. Daujat, J. Pascussi, L. Pichard‐Garcia, M. Vilarem, P. Maurel   +5 more
semanticscholar   +1 more source