Results 11 to 20 of about 342 (115)
Journal of the Endocrine Society, 2022 The nuclear receptor, Constitutive Androstane Receptor (CAR/NR1i3) is extensively known for its detoxification function in the liver. We have identified the role of CAR in regulating androgen levels and regulating testis function.
Anjana Asokakumar +4 more
semanticscholar +1 more source
Journal of the Endocrine Society, 2021 The orphan nuclear receptor, Constitutive Androstane Receptor (CAR, NR1I3) is primarily known to regulate the transcriptional networks involved in detoxification.
J. P. Hernandez +4 more
semanticscholar +1 more source
Journal of Biological Chemistry, 2000 Xenobiotics induce the transcription of cytochromes P450 (CYPs) 2B and 3A through the constitutive androstane receptor (CAR; NR1I3) and pregnane X receptor (PXR; NR1I2), respectively.
L. Moore +11 more
semanticscholar +1 more source
Transcriptional Regulation of CYP2C9 Gene
Journal of Biological Chemistry, 2002 Although cytochrome P450 2C9 (CYP2C9) is a major CYP expressed in the adult human liver, its mechanism of regulation is poorly known. In previous work, we have shown that CYP2C9is inducible in primary human hepatocytes by xenobiotics including ...
S. Gerbal-Chaloin +5 more
semanticscholar +1 more source
Nuclear Receptor, 2003 BackgroundCAR/RXR heterodimers bind a variety of hormone response elements and activate transcription in the absence of added ligands. This constitutive activity of murine CAR can be inhibited by the inverse agonist ligand androstanol or increased by the
Iphigenia Tzameli +3 more
semanticscholar +1 more source
Bile acid homeostasis controls CAR signaling pathways in mouse testis through FXRalpha
Scientific Reports, 2017 Bile acids (BAs) are molecules with endocrine activities controlling several physiological functions such as immunity, glucose homeostasis, testicular physiology and male fertility.
Emmanuelle Martinot +11 more
semanticscholar +1 more source
Toxicological Sciences, 2009 The effects of contaminants are typically studied in individual exposures; however, environmental exposures are rarely from a single contaminant. Therefore, the study of chemical mixtures is important in determining the effects of xenobiotics.
W. S. Baldwin, Jonathan A Roling
semanticscholar +1 more source
The environmental estrogen, nonylphenol, activates the constitutive androstane receptor.
Toxicological Sciences, 2007 Nonylphenol (NP) and its parent compounds, the nonylphenol ethoxylates are some of the most prevalent chemicals found in U.S. waterways. NP is also resistant to biodegradation and is a known environmental estrogen, which makes NP a chemical of concern ...
Juan-Pablo Hernández +5 more
semanticscholar +1 more source
Antibacterial activity of deer musk and Ziziphus spina-christi against carbapebem resis-tant gram negative bacteria isolated from patients with burns and wounds [PDF]
Bacteria were isolated from 250 specimens obtained from patients attending the Plastic Reconstructive and Burn Surgery Hospital in the Sulaymaniyah (Kurdistan region) and the burn and wound care units of the Azadi Teaching Hospital (Kirkuk), Iraq.
K. K. Ahmed, S. A. Hasan, W. M. Raoof
core +2 more sources
Molecular Endocrinology, 2005 Ligand-dependent signal transduction by nuclear receptors (NRs) includes dynamic exchanges of coactivator (CoA) and corepressor (CoR) proteins. Here we focused on the structural determinants of the antagonist- and inverse agonist-enhanced interaction of ...
Harri Lempiäinen +4 more
semanticscholar +1 more source