Results 11 to 20 of about 340 (113)
Nuclear Receptor, 2003 BackgroundCAR/RXR heterodimers bind a variety of hormone response elements and activate transcription in the absence of added ligands. This constitutive activity of murine CAR can be inhibited by the inverse agonist ligand androstanol or increased by the
Iphigenia Tzameli +3 more
semanticscholar +1 more source
Bile acid homeostasis controls CAR signaling pathways in mouse testis through FXRalpha
Scientific Reports, 2017 Bile acids (BAs) are molecules with endocrine activities controlling several physiological functions such as immunity, glucose homeostasis, testicular physiology and male fertility.
Emmanuelle Martinot +11 more
semanticscholar +1 more source
Toxicological Sciences, 2009 The effects of contaminants are typically studied in individual exposures; however, environmental exposures are rarely from a single contaminant. Therefore, the study of chemical mixtures is important in determining the effects of xenobiotics.
W. S. Baldwin, Jonathan A Roling
semanticscholar +1 more source
Scientifica, Volume 2016, Issue 1, 2016., 2016 The paper focuses on the assessment of the spectrum of biological activities (antineoplastic, anti‐inflammatory, antifungal, and antibacterial) with PASS (Prediction of Activity Spectra for Substances) for the major components of three macrophytes widespread in the Holarctic species of freshwater, emergent macrophyte with floating leaves, Nuphar lutea (
Evgeny A. Kurashov +4 more
wiley +1 more source
BioMed Research International, Volume 2014, Issue 1, 2014., 2014 Valeriana officinalis is one of the most popular medicinal plants commonly used as a sedative and sleep aid. It is suggested that its pharmacologically active compounds derived from the root may modulate the CYP3A4 gene expression by activation of pregnane X receptor (PXR) or constitutive androstane receptor (CAR) and lead to pharmacokinetic herb‐drug ...
Anna Bogacz +8 more
wiley +1 more source
Antibacterial activity of deer musk and Ziziphus spina-christi against carbapebem resis-tant gram negative bacteria isolated from patients with burns and wounds [PDF]
Bacteria were isolated from 250 specimens obtained from patients attending the Plastic Reconstructive and Burn Surgery Hospital in the Sulaymaniyah (Kurdistan region) and the burn and wound care units of the Azadi Teaching Hospital (Kirkuk), Iraq.
K. K. Ahmed, S. A. Hasan, W. M. Raoof
core +2 more sources
The environmental estrogen, nonylphenol, activates the constitutive androstane receptor.
Toxicological Sciences, 2007 Nonylphenol (NP) and its parent compounds, the nonylphenol ethoxylates are some of the most prevalent chemicals found in U.S. waterways. NP is also resistant to biodegradation and is a known environmental estrogen, which makes NP a chemical of concern ...
Juan-Pablo Hernández +5 more
semanticscholar +1 more source
Molecular Endocrinology, 2005 Ligand-dependent signal transduction by nuclear receptors (NRs) includes dynamic exchanges of coactivator (CoA) and corepressor (CoR) proteins. Here we focused on the structural determinants of the antagonist- and inverse agonist-enhanced interaction of ...
Harri Lempiäinen +4 more
semanticscholar +1 more source
Molecular Endocrinology, 2005 Activating signal cointegrator-2 (ASC-2) is a recently isolated transcriptional coactivator protein for a variety of different transcription factors, including many members of the nuclear receptor superfamily.
E. Choi +5 more
semanticscholar +1 more source
NONSTEROIDAL ANTIRHEUMATICS AND HYPERTENSION [PDF]
, 2011 Nesteroidni antireumatici (NSAR) skupina su lijekova koji se najčešće rabe u kliničkoj medicini, čine 4–9% svih propisanih lijekova, a bolesnici koji ih uzimaju izloženi su mogućim nuspojavama.
Bojan Jelaković, Krešimir Galešić
core +1 more source