Results 61 to 70 of about 19,672 (173)

Efficacy and safety of HRS‐5965 monotherapy in complement inhibitor–naïve patients with paroxysmal nocturnal haemoglobinuria

British Journal of Haematology, EarlyView.
Summary Paroxysmal nocturnal haemoglobinuria (PNH) is a rare, life‐threatening disorder characterized by complement‐mediated haemolysis, leading to anaemia and thrombosis. HRS‐5965 is a novel, oral, selective complement factor B inhibitor targeting the alternative pathway, potentially reducing both intra‐ and extravascular haemolysis.
Li Zhang, Ziwei Liu, Xin Zhao, Bin Hu, Rong Huang, Chang Shu, Fengkui Zhang, Bing Han   +7 more
wiley   +1 more source

Current strategies against invasive fungal infections in patients with aplastic anemia, strong power and weak weapon, a case report and review of literature

Medical Mycology Case Reports, 2016
We report an 18 year old boy with Aplastic anemia complicated by serious fungal rhinosinusitis. Despite prompt treatment and early repeated surgical debridements, he died after about more than 6 weeks of hard challenges with fungal infections.
Omid Reza Zekavat, Ali Amanati, Fazl Saleh, Babak Abdolkarimi, Gholamreza Fathpour, Parisa Badiee, Bita Geramizadeh   +6 more
doaj   +1 more source

Transcription‐coupled repair: tangled up in convoluted repair

The FEBS Journal, EarlyView.
In this review, we discuss recent findings derived from diverse genomic, biochemical and structural, imaging, and functional studies (B–E) that culminated in deep mechanistic insight (A) into the vital cellular process of transcription‐coupled nucleotide excision repair (TC‐NER).
Diana A. Llerena Schiffmacher, Yun Jin Pai, Alex Pines, Wim Vermeulen   +3 more
wiley   +1 more source

Adding eltrombopag to immunosuppression: the importance of predicting outcome

Haematologica, 2021
André Tichelli, Régis Peffault de Latour, Carlo Dufour, Alicia Rovó   +3 more
doaj   +1 more source

Acute lymphoblastic leukemia of childhood presenting as aplastic anemia: report of two cases

Revista Brasileira de Hematologia e Hemoterapia, 2012
Acute lymphoblastic leukemia is the most common malignancy in pediatric patients; its diagnosis is usually easy to establish as malignant lymphoblasts invade the bone marrow and peripheral blood.
Laura Villarreal-Martínez, José Carlos Jaime-Pérez, Marisol Rodríguez-Martínez, Oscar González-Llano, David Gómez-Almaguer   +4 more
doaj   +1 more source

The PNH French Working Group Experience: Building a Strong Network of Cytometrists

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction The PNH working group was created in 2010 to initiate a workshop on testing white blood cells to share international recommendations. Methods Thirty‐five French and Belgian laboratories equipped with 2‐ or 3‐laser cytometers applied three different panels with or without FLAER reagent in 305 samples.
Orianne Wagner‐Ballon, Magali Le Garff‐Tavernier, Rémi Lestestu, Bernard Drenou, Agathe Debliquis, the PNH French Working Group «CytHem‐HPN», Chantal Fossat, Claire Loosen, Bernard Chatelain, Marie Loosveld   +9 more
wiley   +1 more source

Flow Cytometric Assessment of TRBC1 Expression for the Diagnosis of T‐Cell Lymphoma: Clinical Utility and Pitfalls Related to T‐Cell Clones of Uncertain Significance

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Background T‐cell receptor constant beta chain 1 (TRBC1) has emerged as a potential clonal marker for T‐cell lymphoma. This study evaluated TRBC1 expression using flow cytometry in healthy individuals and various clinical specimens, assessing its clinical utility in the diagnosis of T‐cell lymphomas.
SooHo Yu, Boram Kim, Sang Eun Yoon, Hee‐Jin Kim, Hyun‐Young Kim   +4 more
wiley   +1 more source

Diagnosis, Diagnosis Differensial dan Penatalaksanaan Immunosupresif dan Terapi Sumsum Tulang pada Pasien Anemia Aplastik

e-Jurnal Medika Udayana, 2014
Anemia aplastic is anemia with bone marrow failure characterized by pancytopenia and at themost case with hypoplasia bone marrow. The incidence of anemia aplastic is 3 -6 case per 1million persons per year.
Thaha .., AA Wiradewi Lestari, I Wayan Putu Sutirta Yasa   +2 more
doaj  

Child with aplastic anemia: Anesthetic management

Saudi Journal of Anaesthesia, 2012
Aplastic anemia is a rare heterogeneous disorder of hematopoietic stem cells causing pancytopenia and marrow hypoplasia with the depletion of all types of blood cells.
Manpreet Kaur, Babita Gupta, Aanchal Sharma, Sanjeev Sharma   +3 more
doaj   +1 more source

The Application of Artificial Intelligence‐Based Bone Marrow Cell Analysis System in Pediatric Hematological Diseases

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction The clinical diagnosis of hematological diseases depends on the differential count of nucleated cells on the bone marrow (BM) smears, and an artificial intelligence (AI)‐based system was applied to automatically classify BM nucleated cells in pediatric hematological disease samples in this study.
Xin He, Fei He, Yan Wang, Yu Liu, Xiaopeng Gao, Mingrui Yu, Haiyan Gao   +6 more
wiley   +1 more source