Molecular Testing in Sickle Cell Disease: From Newborn Screening to Transfusion Care
ABSTRACT Sickle cell disease (SCD) is one of the most frequent monogenic diseases worldwide and a highly heterogeneous and complex disease. SCD care carries several challenges. This includes early and accurate diagnosis as well as optimal red blood cell transfusion matching in this population carrying a high risk of alloimmunization.
Thomas Pincez, Yves D. Pastore
wiley +1 more source
ABSTRACT Background G6PD deficiency affects about 500 million people worldwide and is prevalent in many malaria‐endemic settings. People with G6PD deficiency are at risk of hemolysis when exposed to certain medications, including 8‐aminoquinoline drugs used to treat Plasmodium vivax malaria.
Flavia Regina Medeiros da Silva +7 more
wiley +1 more source
A constant rate of DNA damage that is not perfectly repaired will cause a constant rate of DNA mutations. The chance of mutation will increase if DNA is prone to damage, such as occurs in somatic hypermutation (SHM) hotspots and GC‐rich DNA. Thus, if one mutation‐prone DNA site drives disease, the age of onset of disease and degree of penetrance should
Piet C. de Groen
wiley +1 more source
IgG4 anti‐CD47: Erythrophagocytosis and potential transfusion complications
Abstract Background IgG4 monoclonal anti‐CD47 for cancer immunotherapy resulted in anemia necessitating red cell (RBC) transfusions. Although the antibody readily binds to CD47 on RBCs, the mechanism underlying the anemia associated with IgG4 is poorly understood.
Kayluz Frias Boligan +7 more
wiley +1 more source
Zieve's Syndrome in a Patient With Alcohol Use Disorder and Alcohol-Associated Cirrhosis: A Case Report and Review of the Literature. [PDF]
Albusta N.
europepmc +1 more source
Seronegative Autoimmune Hepatitis Presenting With Concurrent Autoimmune Hemolytic Anemia in a 26-Year-Old Woman: A Rare Overlap Syndrome. [PDF]
Marfo E, Sims KM.
europepmc +1 more source
Delayed-Onset Autoimmune Hemolytic Anemia in Advanced HIV With Cerebral Toxoplasmosis. [PDF]
Alahmadi MF +3 more
europepmc +1 more source
Alcohol-Induced Acute Pancreatitis Complicated by Severe Direct Antiglobulin Test (DAT)-Negative Hemolytic Anemia and Thrombocytopenia: A Suspected Evans Syndrome-Like Immune Cytopenia. [PDF]
Arslan Ahmed R +4 more
europepmc +1 more source
Pancytopenia with autoimmune hemolytic anemia
Payal Bargujar +2 more
doaj +1 more source

