Results 91 to 100 of about 18,735 (201)

Paroxysmal Nocturnal Haemoglobinuria‐Associated Acute Cutaneous Thrombosis and Haemolysis in the Setting of Parvovirus B19 and Varicella Zoster Virus Infection

eJHaem, Volume 7, Issue 2, April 2026.
ABSTRACT A 28‐year‐old male with paroxysmal nocturnal haemoglobinuria (PNH) presented with headache, nasal bridge discomfort and haemoglobinuria. He developed a macular‐papular rash which rapidly progressed into purpura, necrosis and peri‐orbital oedema. Investigations demonstrated severe haemolytic anaemia and acute parvovirus B19 infection.
Louise J. Potter, Roochi Trikha, Shreyans Gandhi, Joanne Large, Tanya N. Basu, Jeanne Boissiere, Hannah Devine, Taku Sugai, Aushna Rasool, Austin Kulasekararaj   +9 more
wiley   +1 more source

Autoimmune hemolytic anemia in children

Pediatric Hematology Oncology Journal
Autoimmune hemolytic anaemia (AIHA) is an uncommon cause of antibody-induced hemolytic anemia in children. It is divided into three categories: warm AIHA, cold antibody AIHA and paroxysmal cold hemoglobinuria. The diagnostic work-up typically begins with
Dinesh Chandra, Varun Capoor, Ayoniza Maitri, Rahul Naithani   +3 more
doaj   +1 more source

Liver Cirrhosis and In‐Hospital Outcomes in Patients With Sickle Cell Crises

eJHaem, Volume 7, Issue 2, April 2026.
ABSTRACT Introduction Sickle cell disease (SCD) is a hematologic disorder characterized by chronic hemolysis, vaso‐occlusion, and end‐organ dysfunction. Patients with SCD may experience acute episodes known as sickle cell crises, which are sudden, severe complications typically involving pain or organ‐specific manifestations resulting from vaso ...
Shakirat Gold‐Olufadi, Kayode Ogunniyi, Adeleke Oluwaseun Dorcas, Bukola Florence Tabiti, Dosbai Saparov, Chiamaka Nwachukwu, Henry Becerra, Sravani Bhavanam, Shrestha Neharika, John Ogedegbe, Ifeanyi Nnamdi Uche, Jen Chin Wang, Chinemerem Martlin Emeasoba, Dania Jaamour, Toluwalase Awoyemi   +14 more
wiley   +1 more source

Silent Presentation, Significant Threat: Cold Agglutinin Syndrome After Haploidentical Hematopoietic Stem Cell Transplantation

eJHaem, Volume 7, Issue 2, April 2026.
This graphic abstract presents a comprehensive overview of cold agglutinin syndrome (CAS) following haploidentical hematopoietic stem cell transplantation (haplo‐HSCT) based on the content of our letter, including its clinical scenarios, potential triggers, pathophysiological mechanisms, clinical manifestations, as well as therapeutic and management ...
Zhuoyu An, Liqian Zhang, Peng Zhao, Yun He, Haixia Fu, Yuanyuan Zhang, Xiaodong Mo, Fengrong Wang, Chenhua Yan, Yuqian Sun, Meng Lv, Wei Han, Yuhong Chen, Yingjun Chang, Yu Wang, Lanping Xu, Xiangyu Zhao, Xiaojun Huang, Xiaohui Zhang   +18 more
wiley   +1 more source

Noonan Syndrome Presenting With Severe Transient Thrombocytopenia and Hemolytic Anemia in a Neonate With a Germline PTPN11 Pathogenic Variant

eJHaem, Volume 7, Issue 2, April 2026.
ABSTRACT Noonan syndrome (NS) is a RASopathy that can have hematological presentations, most commonly NS‐related myeloproliferative disorder (NS/MPD) and juvenile myelomonocytic leukemia. Other neonatal hematologic presentations remain poorly defined.
Ariel Gershon, Tanvi Anandampillai, Elaine Suk‐Ying Goh, Caroline Malcolmson, Yiming Wang   +4 more
wiley   +1 more source

Application and Challenges of Chimeric Antigen Receptor T Cell Therapy in Systemic Rheumatic Diseases and Autoimmune Disorders

MedComm, Volume 7, Issue 4, April 2026.
CAR‐T cell therapy in systemic rheumatic diseases and autoimmune disorders. (This figure was created using BioRender.com.) ABSTRACT Chimeric antigen receptor T (CAR‐T) cell therapy, originally developed for hematologic malignancies, has emerged as a transformative candidate for systemic rheumatic diseases and autoimmune disorders (AIDs).
Zhidan Fan, Li Zhang, Haiguo Yu
wiley   +1 more source

Single‐Cell and Spatial Omics: Methods and Applications

MedComm, Volume 7, Issue 4, April 2026.
Systematically summarized the breakthrough sequencing technologies and computational methods for single‐cell and spatial omics across multiple omics layers, including genome, epigenome, transcriptome, proteome, and metabolome. State‐of‐the‐art methods for multi‐omics integration, cross‐modal integration, and cross‐scale integration were reviewed, with ...
Xiaoping Cen, Xiaolan Huang, Enjin Deng, Xue Gong, Na Tan, Jifeng Ye, Yin Wang, Roland Eils, Qun Luo, Yixue Li, Fangfang Qu   +10 more
wiley   +1 more source

Post‐translational Modifications in Proteins: Prediction Methods, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Posttranslational modifications (PTMs) serve as rapid and reversible molecular switches that reshape protein activity, stability, and interactomes, thereby governing virtually all physiological cues ranging from signal transduction to epigenetic memory. Mass spectrometry‐based proteomics has substantially expanded our understanding of PTM emergence and
Shuning Zhang, Jingmin Li, Meihuan Chen, Hailong Huang   +3 more
wiley   +1 more source

Rheumatoid Arthritis–Associated Pleural Effusion in an Elderly Female With Multimorbidity: A Case Report and Diagnostic Challenge

Respirology Case Reports, Volume 14, Issue 4, April 2026.
RA Pleural Effusion is a rare but clinically significant extra‐articular manifestation of RA, presenting diagnostic challenges in patients with multimorbidity. This case underscores the importance of considering autoimmune aetiologies in unexplained exudative pleural effusions, particularly when accompanied by joint symptoms or seropositivity.
Aatif Syed, Abdul Kalam Rawther, Pranav Kumar   +2 more
wiley   +1 more source

Sutimlimab in Patients With Cold Agglutinin Disease (CAD): Results From a Managed Access Program

European Journal of Haematology, Volume 116, Issue 4, Page 409-415, April 2026.
ABSTRACT Cold agglutinin disease (CAD) is a low‐grade lymphoproliferative disorder accounting for 15%–30% of patients suffering from autoimmune hemolytic anemias. The clonal B cells produce autoantibodies primarily of the IgM‐κ class that cause agglutination of red blood cells (RBCs) at temperatures ≤ 37°C and activate the classical complement pathway ...
Sandra Maria Frey, Pauline Halberstadt, Ferras Alashkar, Veronika Lenz, H. Christian Reinhardt, Alexander Röth   +5 more
wiley   +1 more source