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Evaluation of Macrocytic Anemias
Seminars in Hematology, 2015Macrocytic anemia, defined as a mean cell volume (MCV) ≥100 fL in adults, has a narrow differential diagnosis that requires evaluation of the peripheral blood smear as well as additional laboratory testing taken in conjunction with clinical information that includes patient history and physical examination findings.
Ralph, Green, Denis M, Dwyre
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TREATMENT OF MACROCYTIC ANEMIAS
Archives of Internal Medicine, 1955ANEMIAS characterized by large erythrocytes (MCV > 95) are usually caused by lack of one of the erythrocyte maturation factors, vitamin B12or folinic acid. Under these circumstances the young erythrocytes in the bone marrow are megaloblastic and maturation of myeloid elements and megakaryocytes is bizarre.
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Laboratory Medicine, 1990
Megaloblastic anemias result from processes that disrupt DNA synthesis. The condition is usually acquired, with medications, cobalamin, or folate deficiency being common precipitating factors. Many patients with cobalamin or folate deficiency will present with hematologic abnormalities, such as anemia or pancytopenia, along with macroovalocytes and ...
Steven Scates, John Glaspy
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Megaloblastic anemias result from processes that disrupt DNA synthesis. The condition is usually acquired, with medications, cobalamin, or folate deficiency being common precipitating factors. Many patients with cobalamin or folate deficiency will present with hematologic abnormalities, such as anemia or pancytopenia, along with macroovalocytes and ...
Steven Scates, John Glaspy
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Normocytic and macrocytic anemias
Postgraduate Medicine, 1991Differential diagnosis of normocytic and macrocytic anemias is guided by the patient history, physical examination results, reticulocyte count, and specific red blood cell abnormalities identified on the peripheral smear. In some cases this information is sufficient for diagnosis.
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Clinching the diagnosis: macrocytic anemia
Pathology, 1988Macrocytosis is a common laboratory finding. Whether this change requires further attention is dictated by clinical circumstances and concomitant cytopenias or aberrant erythrocyte and leukocyte morphology. The utility of these changes for dictating further investigation and the appropriate "modus operandi" in diagnostic strategies for the adult and ...
M B, Van der Weyden, L, Campbell
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American family physician, 1996
In approximately 2 to 4 percent of patients, laboratory evidence of macrocytosis is found. Macrocytic anemias are classified as those resulting from disorders of DNA synthesis of erythrocyte precursors in bone marrow (megaloblastic anemias) or those caused primarily by alcoholism, liver disease and hypothyroidism (nonmegaloblastic anemias).
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In approximately 2 to 4 percent of patients, laboratory evidence of macrocytosis is found. Macrocytic anemias are classified as those resulting from disorders of DNA synthesis of erythrocyte precursors in bone marrow (megaloblastic anemias) or those caused primarily by alcoholism, liver disease and hypothyroidism (nonmegaloblastic anemias).
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La Revue du praticien, 1989
Macrocytic and/or megaloblastic anaemias of infants and children are more often due to a defective bone marrow production than to haemolysis. They are mostly related to folate and/or cobalamin deficiency or to a disturbance in the metabolism of one of these vitamins (enzyme deficiencies or defect of synthesis of their active forms).
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Macrocytic and/or megaloblastic anaemias of infants and children are more often due to a defective bone marrow production than to haemolysis. They are mostly related to folate and/or cobalamin deficiency or to a disturbance in the metabolism of one of these vitamins (enzyme deficiencies or defect of synthesis of their active forms).
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PERNICIOUS ANEMIA AND RELATED MACROCYTIC ANEMIAS
Archives of Internal Medicine, 1945To the Editor: I should like to present the following concept of pernicious anemia and related macrocytic anemias for the consideration of your readers. Just as pellagra is no longer considered a "disease" if the skin, gastrointestinal tract or nervous system lut is classified rather as a vitamin deficiency disorder, manifested by a disturbance in the
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MACROCYTIC ANEMIA OF PREGNANCY
Journal of the American Medical Association, 1944To the Editor:— The rare macrocytic anemia of pregnancy is a serious and incompletely understood disease. Some writers have considered it a form of pernicious anemia, but most observers have been impressed particularly by its resemblance to the hemolytic anemias.
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Amisulpride-Induced Macrocytic Anemia
The Journal of Neuropsychiatry and Clinical Neurosciences, 2013Sujit, Sarkhel +2 more
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